Clinical features of trigeminal nerve-sheath tumor in 10 dogs

Abstract

Nerve-sheath tumor was diagnosed in 10 dogs with clinical signs of unilateral trigeminal nerve dysfunction. Unilateral temporalis and masseter muscle atrophy were present in all cases. An enlarged foramen and distorted rostral petrous temporal bone were seen with computed tomography imaging in one case. Magnetic resonance imaging was used to identify the lesion accurately in seven cases. Surgery was performed for biopsy and lesion removal in three cases. Cases not treated had a progressive course eventually resulting in euthanasia or death. Of the cases treated surgically, one case is alive without disease progression 27 months after surgery. Survival times of the nontreated cases ranged from five to 21 months.

Anti-tumor effects of nitrosylcobalamin against spontaneous tumors in dogs

“…Survival times of non-treated cases ranged from 5 to 21 months [24]. A study of 12 dogs with MPNST indicated a post-operative median survival of 180 days [25].…”

“…The preferred treatment of malignant peripheral nerve sheath tumors (MPNST), schwannomas or "soft tissue sarcomas" is typically surgical resection although adjuvant radiation therapy has shown some benefit [24]. Survival times of non-treated cases ranged from 5 to 21 months [24].…”

MR Signal Changes of Trigeminal Nuclei in a Case of Suspected Idiopathic Trigeminal Neuropathy in a Staffordshire Bull Terrier

“…6 In cases of nerve-sheath neoplasia, unilateral discrete contrasting enhancing mass lesions are described, with or without displacement of the adjacent brainstem. 3,7,8 No cases of idiopathic trigeminal neuropathy with MR changes within the brainstem, were found on review of the literature.…”

Clinical Course of a Malignant Peripheral Nerve Sheath Tumor in a Siberian Tiger (Panthera Tigris Altaica)

“…In general, tumors of peripheral nerves are locally invasive and slow to metastasize. 1 Histopathologic diagnosis is difficult because PNSTs often lack classical morphological patterns and are thus difficult to differentiate from other spindle-cell tumors such as hemangiopericytomas, fibrosarcoma, anaplastic sarcomas with giant cells, melanoma, leiomyoma, or leiomyosarcoma. 5,7,10,14 Therefore, diagnosis requires further confirmation with immunohistochemical and/or ultrastructural analyses.…”

“…1,2,7,9 Radiation therapy is the treatment of choice if surgical excision lacks clean or tumor-free margins. In the present case, CT images were particularly useful to visualize tumor invasion of local tissue to allow surgical excision with 2-3 cm of grossly normal tissue around the mass and 1 additional tissue plane in depth, including the panniculus muscle that was in contact with the tumor.…”