Clinical features of sleep-related breathing disorders in patients with acromegaly

Tsoy, Uliana; Sviryaev, Yurii; Korostovtseva, L.; Семенов, А. П.; Vaulina, Daria; Nepran, Viktoriya; Kravchenko, S.; Конради, А. О.; Grineva, Elena

doi:10.17116/terarkh201587447-52

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…Another study reported a positive correlation between the severity of sleep-disordered breathing and duration of acromegaly in patients with active disease. Stratifying OSAS patients according to disease severity we observed that severe OSAS patients appear to be affected from acromegaly for more years than those with a lower severity of disease [21] [22].…”

Section: Discussionmentioning

confidence: 84%

Respiratory Disorders in Acromegalic Patients

Mercuri¹,

Villani²,

Costa³

et al. 2019

IJCM

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Purpose: To evaluate the prevalence and clinical performance of obstructive sleep apnoea syndrome (OSAS) in acromegalic patients, focusing on the possible correlation between alterations of pulmonary microcirculation and patient's clinical and hormonal parameters. Methods: We enrolled 22 acromegalic patients with apnea hypopnea index (AHI) ≥ 5 if symptomatic, or ≥15 in the absence of sleep related symptoms. Patients underwent the following evaluations: GH and IGF-1 serum levels, arterial blood gas test, spirometry, carbon monoxide diffusing capacity (DLCO), home-based cardiorespiratory sleep and pulmonary function test. Results: The prevalence of OSAS was 66.6%. Patients with a severe form of OSAS appeared to be affected from acromegaly for more years than those with a lower severity of disease and those with acromegaly duration > 10 years had significantly higher levels of glycated hemoglobin. We observed a positive correlation between GH level at diagnosis and DLCO value, showing that acromegalic patients have an increase in static and dynamic respiratory volumes and alveolar-capillary exchange surface compared to the general population. We also observed a positive correlation between baseline serum IGF-1 level and DLCO/VA and between years of disease and DLCO/VA, showing the association of increased lung volume and increase of the exchange surface. Conclusions: The results of this study add new information on lung volume and alveolar gas exchange in acromegaly. Our findings highlight the role of SSA as therapy with positive impact on complication and comorbidities of acromegaly.

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Section: Discussionmentioning

confidence: 84%

Respiratory Disorders in Acromegalic Patients

Mercuri¹,

Villani²,

Costa³

et al. 2019

IJCM

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“…In acromegaly there is an elevated prevalence of sleep apnoea, as underlined by Hernandez-Gordilo et al [14] , and equally high values (80%) are reported by Tsoi UA et al [15] . The association between hypothyroidism and OSAS is confirmed by variois studies and particularly by Ozcan KM et al [16] , who in a group of 203 patients with OSAS noticed the presence of clinical or subclinical hypothyroidism in 12.…”

mentioning

confidence: 75%

Glaucoma Chronic Angle-Open, Endocrinopathy and Obstructive Sleep Apnea Syndrome: Fortuitous Association or Interaction?

Morreale-Bubella¹

2016

International Journal of Ophthalmic Research

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“…Вероятно, поэтому у больных с впервые выявленной акромегалией, в отличие от общей популяции, ИМТ не является предиктором развития нарушений дыхания во сне. Это показано и в других исследованиях [15,16].…”

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“…Неконтролируемая Контролируемая В нашем исследовании не получено статистически значимой разницы в распространенности нарушений дыхания во сне в зависимости от пола (p>0,05), в отличие от общей популяции, где распространенность нарушения дыхания во сне у мужчин (13-33%) превышает этот показатель у женщин (6-19%) [5]. Несмотря на то что медиана ИАГ выше у мужчин по сравнению с женщинами (38 и 26 соответственно), статистически значимых различий ИАГ у мужчин и женщин не выявлено, что сравнимо с результатами других исследований [15].…”

Section: впервые выявленнаяunclassified

Prevalence and risk factors of sleep breathing disorders in patients with acromegaly from Moscow region

Kovaleva

Древаль

Kulakov

et al. 2018

Terapevticheskii arkhiv

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Aim. Assessment of prevalence and risk factors of sleep breathing disorders in patients with acromegaly from Moscow region. Materials and methods. Cardiorespiratory monitoring was executed to 55 patients with acromegaly (18 men and 37 women): 27 patients with de novo disease, 28 patients on treatment of acromegaly (including 18 patietns with uncontrolled and 10 - with controlled acromegaly). All subgroups did not differ on sex, BMI and age. Also 24-hour monitoring of arterial blood pressure was carried out in 39 patients (12 men and 27 women, 14 patients with de novo acromegaly, 15 and 10 patients with uncontrolled and controlled acromegaly, respectively). Results and discussion. The high prevalence of sleep breathing disorders (SBD) was revealed in patients with acromegaly from Moscow Region. SBD was found in 92.6%, 83.5% and 70.0% patients with newly diagnosed, uncontrolled and controlled acromegaly, respectively. The majority of patients had severe/moderate SBD in all subgroups (78.8%, 72.2% and 60.0%, respectively). In patients with newly diagnosed and uncontrolled acromegaly index of apnea-hypopnea (31 and 38.5 respectively), number of apnoe episodes (76 and 72) and saturation level (93% and 93.5%) did not differ significantly while these parameters were better in patients with a controlled acromegaly (apnea-hypopnea index 20, apnea episodes 45.5 and saturation level 95%). The peak of desaturation was subphysiological in 91.7%, 86.7% and 77.8% of patients with newly diagnosed, uncontrolled and controlled acromegaly, respectively. Severity of SBD did not depend on GH and IGF-1 levels as well as acromegaly duration. Such all-population risk factors of SBD as BMI and age were valuable for patients with acromegaly, however gender did not matter. SBD were associated with lack of physiological decrease of systolic and diastolic night BP. Conclusion. Acromegaly per se is a strong risk factor of sleep breathing disorders. The high prevalence of sleep breathing disorders in patients with acromegaly even after achievement of control over a disease emphasized need of specialized treatment of these violations.

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Clinical features of sleep-related breathing disorders in patients with acromegaly

Cited by 6 publications

References 31 publications

Respiratory Disorders in Acromegalic Patients

Respiratory Disorders in Acromegalic Patients

Glaucoma Chronic Angle-Open, Endocrinopathy and Obstructive Sleep Apnea Syndrome: Fortuitous Association or Interaction?

Prevalence and risk factors of sleep breathing disorders in patients with acromegaly from Moscow region

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