Clinical Features of Rheumatoid Arthritis

Harris, Emily

doi:10.1016/b978-1-4160-3285-4.10066-x

Cited by 109 publications

(70 citation statements)

References 148 publications

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“…Rheumatoid arthritis (RA) is a chronic, multisystemic, inflammatory disease with an unknown etiology that causes progressive destruction in the joints, [1] with the hands and wrists being the most frequent actively involved joints. [2] Hand involvement significantly affects daily living activities, [3] and RA results in the deterioration of hand function by causing swelling, pain, and deformity.…”

mentioning

confidence: 99%

The Relationship Between Hand Grip and Pinch Strengths and Disease Activity, Articular Damage, Pain, and Disability in Patients with Rheumatoid Arthritis

Dedeoğlu

2013

Turk J Rheumatol

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mentioning

confidence: 99%

The Relationship Between Hand Grip and Pinch Strengths and Disease Activity, Articular Damage, Pain, and Disability in Patients with Rheumatoid Arthritis

Dedeoğlu

2013

Turk J Rheumatol

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“…Rheumatoid arthritis (RA) is characterized by chronic inflammation involving connective tissues throughout the body, particularly diarthrodial joints, eventually leading to joint destruction and physical disability 1 . In parallel with erosive arthritis, other extraarticular manifestations have been described in the disease, representing systemic activation of the immune system 1 , which is generally associated with excess mortality 2 .…”

mentioning

confidence: 99%

“…Recent findings support the idea that immune-inflammatory processes associated with RA contribute to the increased risk of ischemic CV disease 11,23,24 . Inflammatory cytokines that are produced in excess in RA (e.g., tumor necrosis factor-α, platelet-derived growth factor) activate endothelial and subendothelial myofibroblasts that might lead to the accumulation of immunocompetent cells in atherosclerotic plaques 1 . Classical Framingham as well as other potential risk factors for accelerated atherosclerosis in RA are summarized in Table 1 5,11 .…”

mentioning

confidence: 99%

Accelerated Atherosclerosis in Rheumatoid Arthritis: Rationale for Mannose-binding Lectins?: Table 1.

Nakken¹,

Szodoray²

2010

J Rheumatol

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“…Many wide-ranging treatment modalities exist for PR, but to date, no consensus exists regarding which is the best. 8,10 We prescribed non-steroidal anti-inflammatory drugs, prednisone, and methotrexate to our patient, and during the follow-up period, she reported that she experienced a remission of her arthritic attacks as a by-product of using these drugs.…”

mentioning

confidence: 99%

Palindromic Rheumatism-Like Migratory Non-Erosive Seronegative Polyarthritis in a Patient With Metastatic Conjunctival Malignant Melanoma

Analan

2016

Arch Rheumatol

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Malignant melanoma of the conjunctiva is an extremely rare extraocular neoplasm. Local recurrence and metastases of this malignancy have been well documented in the literature, 1,2 but there does not seem to be any information regarding cases of paraneoplastic polyarthritis arising from this metastatic malignancy. Herein, we describe the case of a patient with palindromic rheumatism (PR)-like migratory non-erosive seronegative polyarthritis in conjunction with metastatic conjunctival malignant melanoma.A 51-year-old female patient was admitted to our clinic with a three-year history of transient and recurrent pain and swelling in her left upper extremity. She had been diagnosed with left conjunctival malignant melanoma with multiple metastases. She started to feel pain and swelling in her left shoulder that radiated to all of the joints in her left upper extremity in the form of migratory and transient recurrent attacks. At times, these symptoms would subside completely without any residual disability, but they would then begin again in other joints of the same extremity. The symptoms always developed quickly and reached their peak within a few days. She had variable symptom-free intervals between the attacks which coincided with her history of pain and swelling.Her physical examination revealed active arthritis in her upper extremity joints. Laboratory tests found an erythrocyte sedimentation rate of 84 mm/h and a C-reactive protein level of 38.8 mg/L, but her rheumatoid factor serum and anti-cyclic citrullinated peptide antibody levels were within normal limits. The plain radiographs were normal.She was prescribed non-steroidal antiinflammatory drugs, prednisone 5 mg/per day, oral methotrexate 7.5 mg/per week, and folinic acid 5 mg/per week. At the first follow-up appointment, patient's attacks had resolved completely with these medications.Palindromic rheumatism is an uncommon condition characterized by irregular, recurrent episodes of mostly oligoarticular arthritis with peri-and para-articular tissue inflammation that can last from a few hours to several days with variable symptom-free intervals. It leaves no residual clinical and radiographic changes, and between attacks, the joints are completely normal and asymptomatic. Because no distinct clinical, laboratory, or radiological markers have been identified, a diagnosis of PR is currently based on clinical features and the exclusion of other forms of episodic arthritis.3-8 Laboratory tests should also show an elevated erythrocyte sedimentation rate and a higher number of acute phase reactants during the attacks, with these remaining at normal levels between the attacks. 4,6,9 Our patient

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Clinical Features of Rheumatoid Arthritis

Cited by 109 publications

References 148 publications

The Relationship Between Hand Grip and Pinch Strengths and Disease Activity, Articular Damage, Pain, and Disability in Patients with Rheumatoid Arthritis

The Relationship Between Hand Grip and Pinch Strengths and Disease Activity, Articular Damage, Pain, and Disability in Patients with Rheumatoid Arthritis

Accelerated Atherosclerosis in Rheumatoid Arthritis: Rationale for Mannose-binding Lectins?: Table 1.

Palindromic Rheumatism-Like Migratory Non-Erosive Seronegative Polyarthritis in a Patient With Metastatic Conjunctival Malignant Melanoma

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