Clinical Features of Re-Emerging Hepatitis A: An Analysis of Patients Hospitalized during an Urban Epidemic in Korea

Choi, Hee Kyoung; Song, Young Goo; Kim, Chang Oh; Shin, So Youn; Chin, Bum Sik; Han, Sang Hoon; Jin, Sung Joon; Chae, Yun Tae; Baek, Ji Hyeon; Kim, Sun Bean; Kim, Do Young; Park, Jun Yong; Kim, June Myung; Choi, Jun Yong

doi:10.3349/ymj.2011.52.4.686

Cited by 9 publications

(6 citation statements)

References 20 publications

(25 reference statements)

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“…Older age is classically related to greater morbidity and HA mortality; however, it is not clear as to whether this is directly due to liver damage or decomposition of underlying disease 33. Choi, et al34 reported that patients >40 years of age did not show differences in clinical outcomes. Similar to these results, the population of this study ranged from 20-60 years of age, and ALF developed between 25-40 years of age.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Indicators for Acute Liver Failure Development and Mortality in Patients with Hepatitis A: Consecutive Case Analysis

et al. 2014

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PurposeDue to the seroepidemiological shift in hepatitis A (HA), its severity, mortality, and complications have increased in recent years. Thus, the aim of this study was to identify predictive factors associated with poor prognosis among patients with HA.Materials and MethodsA total of 304 patients with HA admitted to our institution between July 2009 and June 2011 were enrolled consecutively. Patients with complications defined as acute liver failure (ALF) were evaluated, and mortality was defined as death or liver transplantation.ResultsThe mean age of patients (204 males, 100 females) was 32 years. Eighteen (5.9%) patients had progressed to ALF. Of the patients with ALF, 10 patients (3.3%) showed spontaneous survival while 8 (2.6%) died or underwent liver transplantation. Multivariate regression analysis showed that Model for End-Stage Liver Disease (MELD) and systemic inflammatory response syndrome (SIRS) scores were significant predictive factors of ALF. Based on receiver operating characteristics (ROC) analysis, a MELD ≥23.5 was significantly more predictive than a SIRS score ≥3 (area under the ROC: 0.940 vs. 0.742, respectively). In addition, of patients with a MELD score ≥23.5, King's College Hospital criteria (KCC) and SIRS scores were predictive factors associated with death/transplantation in multivariate analysis.ConclusionMELD and SIRS scores ≥23.5 and ≥3, respectively, appeared to be related to ALF development. In addition, KCC and SIRS scores ≥3 were valuable in predicting mortality of patients with a MELD ≥23.5.

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Section: Discussionmentioning

confidence: 99%

Prognostic Indicators for Acute Liver Failure Development and Mortality in Patients with Hepatitis A: Consecutive Case Analysis

et al. 2014

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“…In a local study, the prevalence of seropositive individuals was just 6.2% in the 20-29 age group (10). Hepatitis A cases in Korea have been increasing since 1998, as shown in the number of patients who receive liver transplants or death due to the disease (11). …”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Acute Hepatitis A Infection in Korea in 2007 and 2009: A Case-Control Study

Seo

Choi

et al. 2013

J Korean Med Sci

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This study aimed to identify the risk factors associated with acute hepatitis A virus (HAV) infection in the Korean population. Participants were recruited from five referral hospitals across the country in 2007 and from 11 hospitals in 2009. Patients with positive anti-HAV IgM antibody tests became the case group, while patients treated for non-contagious diseases at the same hospitals were recruited as controls. A total of 222 and 548 case-control pairs were studied in the 2007 and 2009 surveys, respectively. Data from the surveys were analyzed jointly. In a multivariate analysis, sharing the household with HAV-infected family members (OR, 6.32; 95% CI, 1.4-29.6), contact with other HAV-infected individuals (OR, 4.73; 95% CI, 2.4-9.4), overseas travel in 2007 (OR, 19.93; 95% CI, 2.3-174.4), consumption of raw shellfish (OR, 2.51; 95% CI, 1.8-3.5), drinking bottled water (OR, 1.64; 95% CI, 1.3-8.4), and occupation that involve handling food (OR, 3.30; 95% CI, 1.3-8.4) increased the risk of HAV infection. Avoiding contact with HAV-infected individuals and avoiding raw foods eating could help minimize the risk of hepatitis A infection. Immunization must be beneficial to individuals who handle food ingredients occupationally or travel overseas to HAV-endemic areas.

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“…Lifelong immunity is often acquired after HAV infection [3], and hepatitis A during childhood is generally asymptomatic or causes flu-like symptoms. However, it is also associated with symptoms that range from nausea and vomiting to fulminant hepatitis and death among adults [1,2,4,5]. Unfortunately, hepatitis A is one of the most common infectious diseases in the world [6], and its incidence varies according to socioeconomic development and public sanitation.…”

Section: Introductionmentioning

confidence: 99%

Age-period-cohort analysis of hepatitis A incidence rates in Korea from 2002 to 2012

Seo

Choi

et al. 2016

Epidemiol Health

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OBJECTIVESThis study aimed to evaluate the epidemiology of hepatitis A in Korea from 2002 to 2012 using age-period-cohort analyses.METHODSWe used claims data from the Korean National Health Insurance Corporation for the entire population. Census data from 2010 were used as the standard population. The incidence of hepatitis A was assumed to have a Poisson distribution, and the models and effects were evaluated using the intrinsic estimator method, the likelihood ratio, and the Akaike information criterion.RESULTSThe incidence of hepatitis A gradually increased until 2007 (from 17.55 to 35.72 per 100,000 population) and peaked in 2009 (177.47 per 100,000 population). The highest incidence was observed among 27-29-year-old individuals when we omitted data from 2005 to 2007. From 2005 to 2007, the peak incidence was observed among 24-26-year-old individuals, followed by 27-29-year-olds. The best model fits were observed when the age-period-cohort variables were all considered at the same time for males, females, and the whole population.CONCLUSIONSThe incidence of hepatitis A exhibited significant age-period-cohort effects; its incidence peaked in 2009 and was especially high among Koreans 20-39 years of age. These epidemiological patterns may help predict when high incidence rates of hepatitis A may occur in developing countries during their socioeconomic development.

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Clinical Features of Re-Emerging Hepatitis A: An Analysis of Patients Hospitalized during an Urban Epidemic in Korea

Cited by 9 publications

References 20 publications

Prognostic Indicators for Acute Liver Failure Development and Mortality in Patients with Hepatitis A: Consecutive Case Analysis

Prognostic Indicators for Acute Liver Failure Development and Mortality in Patients with Hepatitis A: Consecutive Case Analysis

Risk Factors for Acute Hepatitis A Infection in Korea in 2007 and 2009: A Case-Control Study

Age-period-cohort analysis of hepatitis A incidence rates in Korea from 2002 to 2012

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