Clinical features of psoriatic uveitis in Japanese patients

Tanaka, Rie; Takamoto, Masao; Komae, Keiko; Ohtomo, Kazuyoshi; Fujino, Yujiro; Kaburaki, Toshikatsu

doi:10.1007/s00417-015-2968-4

Cited by 15 publications

(27 citation statements)

References 24 publications

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“…Previous studies have shown that patients with uveitis associated with psoriasis usually exhibit acute non-granulomatous anterior uveitis, which is consistent with the findings for our current patient [6]. A recent large-scale study demonstrated that a group of patients with severe psoriasis who received systemic therapy had an increased risk of uveitis compared to patients with mild psoriasis who did not receive any systemic therapy [2].…”

Section: Discussionsupporting

confidence: 90%

“…Although it has been thought that posterior segment inflammation rarely occurs, several recent studies have reported finding posterior segment lesions [3, 4, 5]. Furthermore, about half of the patients become affected bilaterally several years after the original onset [6]. Tumor necrosis factor alpha (TNF-α) is an important inflammatory cytokine that is involved in various inflammatory diseases, including rheumatoid arthritis (RA), Crohn's disease, Behçet's disease, and psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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Successful Certolizumab Pegol Treatment of Chronic Anterior Uveitis Associated with Psoriasis Vulgaris

Yamaguchi

Hayashi

Takahashi

et al. 2018

Case Rep Ophthalmol

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This report presents details on a 45-year-old male Japanese patient with chronic and refractory anterior uveitis associated with psoriasis vulgaris who was administered certolizumab pegol (CZP), which is an anti-tumor necrosis factor alpha (TNF-α) monoclonal antibody. Although CZP has only been formally approved for rheumatoid arthritis treatment in Japan, a clinical trial allowed us to assess CZP effectiveness in this patient. The grade 3+ anterior chamber inflammation (for both the cells and flare) observed at baseline improved to grade 0 at 3 months post-treatment. Dermatologically, the psoriasis area severity index (PASI) score was 25.4, while the body surface area (BSA) was 88% at baseline. At 3 months after treatment, the scores improved to 2.8 for PASI and less than 1% for BSA. After the treatment, remission has lasted for at least 9 months. No adverse events were seen during the CZP treatment. These findings suggest that CZP could be an effective therapeutic alternative in some refractory anterior uveitis patients with psoriasis vulgaris.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Successful Certolizumab Pegol Treatment of Chronic Anterior Uveitis Associated with Psoriasis Vulgaris

Yamaguchi

Hayashi

Takahashi

et al. 2018

Case Rep Ophthalmol

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“…14,15 In conclusion, erythrodermic psoriasis concomitant with uveitis is relatively rare, and it is essential to treat both the ocular inflammation and primary disease. 16 Treatment with biological agents should be recommended as a primary strategy for erythrodermic psoriasis with uveitis because of their rapid onset of action and achievement of long-term remission. The selection of biological agents for this condition remains a challenge.…”

Section: Discussionmentioning

confidence: 99%

Successful secukinumab treatment of erythrodermic psoriasis and psoriatic arthritis concomitant with severe noninfectious uveitis: a case report

Tang

et al. 2020

J Int Med Res

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Uveitis is considered a relatively rare but serious ocular complication of psoriasis. We report the first successful treatment of severe noninfectious uveitis with secukinumab in a 70-year-old woman with erythrodermic psoriasis and psoriatic arthritis. Anti-tumor necrosis factor (TNF) agents were administered for 5 years for the treatment of erythrodermic psoriasis and psoriatic arthritis. Although the symptoms improved, she later developed noninfectious uveitis, resulting in a sharp decline in vision. After switching to secukinumab, her vision slightly improved, her skin lesions subsided, and her joint symptoms were relieved. Given the rarity of psoriasis combined with uveitis, it is unclear whether uveitis is related to anti-TNF therapy. In addition, the selection of effective biological agents for the treatment of uveitis remains a challenge and requires extensive clinical experience.

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“…Intravitreal injection of vancomycin as is done in some centers after cataract surgery has been rarely associated with retinal vasculitis 14 . Patients with birdshot chorioretinopathy 15 and uveitis in association with psoriasis 16 were also noted to have a predisposition to retinal vasculitis.…”

Section: Novel Insightsmentioning

confidence: 99%

Retinal vasculitis

Rosenbaum

Sibley

Lin

2016

Current Opinion in Rheumatology

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Purpose of review Ophthalmologists and rheumatologists frequently miscommunicate in consulting on patients with retinal vasculitis. This report seeks to establish a common understanding of the term, retinal vasculitis, and to review recent papers on this diagnosis. Recent findings 1) The genetic basis of some rare forms of retinal vascular disease have recently been described. Identified genes include CAPN5, TREX1, and TNFAIP3; 2) Behçet’s disease is a systemic illness that is very commonly associated with occlusive retinal vasculitis; 3) retinal imaging including fluorescein angiography and other newer imaging modalities has proven crucial to the identification and characterization of retinal vasculitis and its complications; 4) although monoclonal antibodies to IL-17A or IL-1 beta failed in trials for Behçet’s disease, antibodies to TNF alpha, either infliximab or adalimumab, have demonstrated consistent benefit in managing this disease. Interferon treatment and B cell depletion therapy via rituximab may be beneficial in certain types of retinal vasculitis. Summary Retinal vasculitis is an important entity for rheumatologists to understand. Retinal vasculitis associated with Behçet’s disease responds to monoclonal antibodies that neutralize TNF, but the many other forms of non-infectious retinal vasculitis may require alternate therapeutic management.

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Clinical features of psoriatic uveitis in Japanese patients

Abstract: Cases of psoriatic uveitis in Japan appear to present with acute non-granulomatous uveitis; other symptoms may include macular edema, retinal vasculitis, or hyperemic disc.

Cited by 15 publications

References 24 publications

Successful Certolizumab Pegol Treatment of Chronic Anterior Uveitis Associated with Psoriasis Vulgaris

Successful Certolizumab Pegol Treatment of Chronic Anterior Uveitis Associated with Psoriasis Vulgaris

Successful secukinumab treatment of erythrodermic psoriasis and psoriatic arthritis concomitant with severe noninfectious uveitis: a case report

Retinal vasculitis

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