Clinical features of psoriatic arthritis

Kishimoto, Mitsumasa; Deshpande, Gautam A.; Fukuoka, Kazuhito; Kondo, Takahisa; Ikegaya, Noriko; Kawashima, Soko; Komagata, Yoshinori; Kaname, Shinya

doi:10.1016/j.berh.2021.101670

Cited by 33 publications

(27 citation statements)

References 29 publications

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“…Interestingly, an equal proportion of diseased males and females reported joint pain ( Figure 1 b), which is a major characteristic feature of psoriasis [ 16 ]. PASI scores were categorized as mild, moderate and, severe [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

Association of CARD14 Single-Nucleotide Polymorphisms with Psoriasis

Suleman

Chhabra

Raza

et al. 2022

IJMS

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Psoriasis is an immune-mediated chronic and painful disease characterized by red raised patches of inflamed skin that may have desquamation, silvery-white scales, itching and cracks. The susceptibility of developing psoriasis depends on multiple factors, with a complex interplay between genetic and environmental factors. Studies have suggested an association between autosomal dominant CARD14 (caspase recruitment domain-containing protein 14) gain-of-function mutations with the pathophysiology of psoriasis. In this study, non-synonymous single-nucleotide polymorphisms (nsSNPs) of CARD14 gene were assessed to determine their association with psoriasis in Pakistani population. A total of 123 subjects (63 patients with psoriasis and 60 normal controls) were included in this study. DNA was extracted from blood, and PCR analysis was performed followed by Sanger sequencing for 18 CARD14 specific nsSNPs (14 previously reported and the 4 most pathogenic nsSNPs identified using bioinformatics analysis). Among the 18 tested SNPs, only 2 nsSNP, rs2066965 (R547S) and rs34367357 (V585I), were found to be associated with psoriasis. Furthermore, rs2066965 heterozygous genotype was found to be more prevalent in patients with joint pain. Additionally, the 3D structure of CARD14 protein was predicted using alpha-fold2. NMSim web server was used to perform coarse grind simulations of wild-type CARD14 and two mutated structures. R547S increases protein flexibility, whereas V353I is shown to promote CARD14-induced NF-kappa B activation. This study confirms the association between two CARD14 nsSNPs, rs2066965 and rs34367357 with psoriasis in a Pakistani population, and could be helpful in identifying the role of CARD14 gene variants as potential genetic markers in patients with psoriasis.

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Section: Resultsmentioning

confidence: 99%

Association of CARD14 Single-Nucleotide Polymorphisms with Psoriasis

Suleman

Chhabra

Raza

et al. 2022

IJMS

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“…Следует дифференцировать воспалительные изменения от дегенеративных [63], особенно с учетом того, что у значительного числа пациентов заболевание развивается после 40 лет [4,43]. В литературе обсуждается вопрос о том, что для аксПсА более характерен асимметричный СИ (до 73% случаев) [55, [64][65][66], особенности которого подробно рассматривались выше. В то же время D.R.…”

Section: методы визуализацииunclassified

“…Интересно, что при обоих заболеваниях у мужчин более выражены структурные повреждения, а у женщин -выше воспалительная активность [97,98]. При аксПсА по сравнению с АС наблюдается менее выраженный СИ [12,42,62,68], реже развивается анкилоз КПС [62], изменения в КПС менее симметричны [42,55,62,[64][65][66]68], чаще выявляется односторонний и реже -двусторонний СИ [94]. Принципиальным отличием аксПсА от АС является возможность поражения позвоночника без СИ [12].…”

Section: дифференциальная диагностика акспса с ас и аксиальным спаunclassified

Axial involvement in psoriatic arthritis

Gubar¹,

Коротаева²

2022

Naučno-praktičeskaâ revmatologiâ

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Among the variety of clinical manifestations of psoriatic arthritis (PsA) – including peripheral arthritis, dactylitis, enthesitis, and axial disease – spondylitis is the least studied. There is no generally accepted definition of axial PsA (axPsA), nor is there any common terminology or diagnostic criteria for it. In the rheumatology community, there is also no consensus regarding radiological and MRI assessment of axial involvement in PsA patients, while disease activity indexes and the therapeutic tactics are borrowed from those used in treating axial spondyloarthritis (axSpA) and ankylosing spondylitis (AS). However, despite a range of similarities in immunopathogenetic mechanisms of axPsA and axSpA, there are also certain differences that may affect the treatment response in these patients. The aim of this review is the analysis of data on axial disease in PsA. The article discusses the genetic features, clinical presentations, imaging techniques, differential diagnostics and treatment options of axPsA.

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“…Thus, a prompt diagnosis of PsA can be achieved with an accurate clinical assessment and evaluation of skin and nail lesions in patients with other musculoskeletal disorders [17]. With this purpose, in clinical setting the presence of a multidisciplinary team including dermatology and rheumatology specialists could increase early diagnosis and optimize care of PsA patients [18].…”

Section: Clinical Featuresmentioning

confidence: 99%

Hand Erosive Osteoarthritis and Distal Interphalangeal Involvement in Psoriatic Arthritis: The Place of Conservative Therapy

Poletto

Tinazzi

Marchetta

et al. 2021

JCM

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Hand erosive osteoarthritis (HEOA) and Psoriatic Arthritis (PsA) with DIP involvement are common diseases affecting the hand. Both of them evolve with a progressive limitation in grip due to limited range of motion of the affected joints and stenosing tenosynovitis. Pharmacological options currently available (corticosteroids and clodronate or Idrossicloroquine) for the treatment of EHOA are mostly symptomatic and currently there are no effective drugs able to modify the course of the disease. In addition, data on drug effectiveness of PsA with DIP involvement are lacking. Conservative therapy should be considered in order to reduce pain and improve hand functionality. There are many studies debating a wide range of non-pharmacological intervention in the management of HEOA: joint protection program, range of motion and strengthening exercise, hand exercise with electromagnetic therapy, application of heat with paraffin wax or balneotherapy, occupational therapy and education. Concerning conservative treatment strategies to treat PsA, on the contrary, current evidence is still weak. Further research is needed to find the correct place of physical therapy to prevent stiffness and ankylosis due to the vicious circle of inflammation-pain-immobility-rigidity.

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Clinical features of psoriatic arthritis

Cited by 33 publications

References 29 publications

Association of CARD14 Single-Nucleotide Polymorphisms with Psoriasis

Association of CARD14 Single-Nucleotide Polymorphisms with Psoriasis

Axial involvement in psoriatic arthritis

Hand Erosive Osteoarthritis and Distal Interphalangeal Involvement in Psoriatic Arthritis: The Place of Conservative Therapy

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