Clinical features of prefrail older individuals and emerging peripheral biomarkers: A systematic review

Fernández-Garrido, Julio; Ruiz-Ros, Vicente; Buigues, Cristina; Navarro-Martínez, Rut; Cauli, Omar

doi:10.1016/j.archger.2014.02.008

Cited by 76 publications

(62 citation statements)

References 110 publications

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“…Many reports have demonstrated that frailty is more common in women, (Bartali et al, 2006;Cappola et al, 2009;Fernández-Garrido et al, 2014b;Kamel, 2003) indeed specific pre-operative frailty assessments are well-accepted by gynecological cancer patients, and are a feasible tool in a clinical setting (CourtneyBrooks et al, 2012). Dale et al (2014) demonstrated that previous knowledge about the exhaustion or physical performance deficits in patients with pancreatic tumour considered suitable for pancreaticoduodenectomy can help to predict clinically relevant outcomes.…”

Section: Discussionmentioning

confidence: 97%

Frailty syndrome and pre-operative risk evaluation: A systematic review

Buigues

Juarros-Folgado

Fernández-Garrido

et al. 2015

Archives of Gerontology and Geriatrics

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Section: Discussionmentioning

confidence: 97%

Frailty syndrome and pre-operative risk evaluation: A systematic review

Buigues

Juarros-Folgado

Fernández-Garrido

et al. 2015

Archives of Gerontology and Geriatrics

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“…Estimates also suggest that at least 1 million (Hoover et al 2013) and up to one-quarter of Canadians aged over 65 years are frail (Muscedere et al 2016). Pre-frailty is anticipated to be higher at 35%-50% in those over age 60 years, and especially women, with weakness being the most common criteria reported (Fernández-Garridoa et al 2014).…”

Section: Prevalence Of Frailtymentioning

confidence: 99%

“…Interventions for preventing or minimizing the effects of frailty in older adults include physical activity, nutrition, and lifestyle changes (Artaza-Artabe et al 2016;Cadore et al 2013;Chou et al 2012;Daniels et al 2008;de Vries et al 2012). The pre-frail population may benefit from treatment, yet are often excluded from interventions comparing frail to nonfrail participants (Fernández-Garridoa et al 2014).…”

Section: Health Implications Of Frailtymentioning

confidence: 99%

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Malnutrition or frailty? Overlap and evidence gaps in the diagnosis and treatment of frailty and malnutrition

Laur

McNicholl

Valaitis

et al. 2017

Appl. Physiol. Nutr. Metab.

123

116

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Abstract:There is increasing awareness of the detrimental health impact of frailty on older adults and of the high prevalence of malnutrition in this segment of the population. Experts in these 2 arenas need to be cognizant of the overlap in constructs, diagnosis, and treatment of frailty and malnutrition. There is a lack of consensus regarding the definition of malnutrition and how it should be assessed. While there is consensus on the definition of frailty, there is no agreement on how it should be measured. Separate assessment tools exist for both malnutrition and frailty; however, there is intersection between concepts and measures. This narrative review highlights some of the intersections within these screening/assessment tools, including weight loss/decreased body mass, functional capacity, and weakness (handgrip strength). The potential for identification of a minimal set of objective measures to identify, or at least consider risk for both conditions, is proposed. Frailty and malnutrition have also been shown to result in similar negative health outcomes and consequently common treatment strategies have been studied, including oral nutritional supplements. While many of the outcomes of treatment relate to both concepts of frailty and malnutrition, research questions are typically focused on the frailty concept, leading to possible gaps or missed opportunities in understanding the effect of complementary interventions on malnutrition. A better understanding of how these conditions overlap may improve treatment strategies for frail, malnourished, older adults.Key words: frailty, malnutrition, screening, assessment, diagnosis, handgrip strength, oral nutritional supplements, older adult.Résumé : Les effets néfastes de la fragilité des personnes âgées sur leur santé ainsi que la forte prévalence de malnutrition dans cette strate de la population suscitent une prise de conscience grandissante. Les experts dans ces deux domaines doivent être au fait du chevauchement des construits, du diagnostic et du traitement de la fragilité et de la malnutrition. Il n'y a pas encore de consensus au sujet de la définition de la malnutrition et de son évaluation. Concernant la fragilité, on s'entend sur sa définition, mais pas sur sa mesure. Il existe pourtant des outils distincts de mesure de la malnutrition et de la fragilité et, d'ailleurs, les concepts et mesures présentent une intersection. Cette revue narrative souligne les intersections entre les outils de dépistage et d'évaluation comme la perte de poids/diminution de la masse corporelle, de la capacité fonctionnelle et la faiblesse (force de préhension manuelle). En guise de tentative, on propose un ensemble minimal de mesures objectives pour la détermination ou, à tout le moins, l'identification d'un risque dans les deux conditions. La fragilité et la malnutrition aboutissent, études à l'appui, à des problèmes de santé similaires justifiant des stratégies communes de traitement tels les suppléments nutritionnels oraux. Alors que plusieurs résultats du traitement c...

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“…Consequently, considerable research efforts have been directed towards the development and validation of biomarkers for frail patients [12][13][14]. Some of the most investigated biomarkers in relation to frailty in seniors are interleukin-6 (IL-6) and C-reactive-protein (CRP) [15][16][17] (related to inflammatory response), albumin [15,18] (nutritional parameters and liver function], insulingrowth factor (IGF-1) [19] and Vitamin D 25-OH [20] (muscle regulation) as well as glucose [21].…”

Section: Introductionmentioning

confidence: 99%