Clinical Features of Patients with Home Isolation Sars-Cov-2 Infection: A Multicenter Retrospective Study in Southern Italy

Abstract

To describe epidemiological and clinical features of patients confirmed as having SARS-CoV-2 infection and managed in isolation at home. We performed a multicenter retrospective study enrolling all SARS-CoV-2-positive adults evaluated from 28 February to 31 May 2020 at one of nine COVID-19 Units in southern Italy: we included patients receiving care at home and those admitted to hospital. We defined patients with not-severe disease if they were asymptomatic or experienced a mild infection that did not need oxygen (O2) therapy and those with a severe infection if hospitalized and required O2 therapy. We enrolled 415 patients with SARS-CoV-2 infection: 77 were managed in isolation at home, 338 required hospital management. The 77 patients in home isolation were less frequently male than hospitalized patients (55% vs. 64%; <0.01) and were younger (median age 45 years (IQR:19) vs. 62 (IQR 22); p < 0.01), had a lower Charlson comorbidity index (median 0 (IQR2) vs. 6 (IQR 3); p < 0.01), and included fewer subjects with an underlying chronic disease (36% vs. 59%; p < 0.01). According to a binomial logistic regression analysis, a younger age (OR: 0.96 (95% IC: 0.94–0.98), p < 0.01) and a low Charlson comorbidity index (OR: 0.66 (95% IC: 0.54–0.83); p < 0.01) were independent factors associated with at-home management. The identification of subjects with SARS-CoV-2 infection who could be managed in home isolation is useful in clinical practice. A younger age and no comorbidities were identified as factors independently associated with home management.

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Prognostic Value of Transaminases and Bilirubin Levels at Admission to Hospital on Disease Progression and Mortality in Patients with COVID-19—An Observational Retrospective Study

“…Acknowledgments: Campania COVID-19 network [30]: Nicola Coppola, Caterina Monari, Caterina Sagnelli, Paolo Maggi, Vincenzo Sangiovanni, Fabio Giuliano Numis, Ivan Gentile, Alfonso Masullo, Carolina Rescigno, Giosuele Calabria, Angelo Salomone Megna, Michele Gambardella, Elio Manzillo, Grazia Russo, Vincenzo Esposito, Giuseppina Dell'Aquila, Roberto Parrella, Rodolfo Punzi, Antonio Ponticiello, Mariantonietta Pisaturo, Enrico Allegorico, Raffaella Pisapia, Giovanni Porta, Margherita Macera, Federica Calò, Anna Maria Rossomando, Mariana Di Lorenzo, Antonio Russo, Giorgio Bosso, Claudia Serra, Ferdinando Dello Vicario, Valentina Minerva, Giulia De Angelis, Stefania De Pascalis, Giovanni Di Caprio, Addolorata Masiello, Domenica Di Costanzo, Mariano Mazza, Vincenzo Bianco, Valeria Gentile, Antonio Riccardo Buonomo, Biagio Pinchera, Riccardo Scotto, and Fabiana Mancini. We give thanks to Vittorio Simeon (Medical Statistics Unit, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", Napoli, Italy) for the help provided in the revision of the tables.…”