Clinical Features of Nephrotic Syndrome with Cerebral Hemorrhage

Yang, Mengqi; Pan, Xin-Bin; Liang, Zhijian; Huang, Xiaoqin; Duan, Meiyi; Cai, Hui; Yu, Lixia; Chen, Li

doi:10.12659/msm.912466

Cited by 8 publications

(11 citation statements)

References 33 publications

(39 reference statements)

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“…The clinical characteristics and outcome of patients with NS and ICH were seldom reported. Only one study demonstrates 15 patients with ICH and NS [ 11 ]. In this study, more than half of the patients presented with comatose status, and a majority of NS patients with ICH had a poor prognosis [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Only one study demonstrates 15 patients with ICH and NS [ 11 ]. In this study, more than half of the patients presented with comatose status, and a majority of NS patients with ICH had a poor prognosis [ 11 ]. Our study, which recruited 57 patients with ICH, demonstrates that SAH and IH had higher mortality than other ICH subtypes (75% and 22.2 %, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, intracranial hemorrhage (ICH) is also seen in patients with NS [ 9 – 11 ]. This cerebral hemorrhage, which could be associated with intravascular deposition of immune complexes or systemic amyloidosis [ 12 – 14 ], can occur in patients with NS without stroke risk factors [ 11 , 15 , 16 ]. Biochemical abnormalities, such as proteinuria, D-dimer levels, hyperlipidemia, and renal function impairment, are associated with the occurrence of ICH in patients with NS [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…This cerebral hemorrhage, which could be associated with intravascular deposition of immune complexes or systemic amyloidosis [ 12 – 14 ], can occur in patients with NS without stroke risk factors [ 11 , 15 , 16 ]. Biochemical abnormalities, such as proteinuria, D-dimer levels, hyperlipidemia, and renal function impairment, are associated with the occurrence of ICH in patients with NS [ 11 ]. However, the small numbers of patients in these studies limit further understanding of the clinical outcome and potential pathogenesis in this subpopulation of patients.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of ischemic stroke and intracranial hemorrhage in patients with nephrotic syndrome

et al. 2021

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Background The incidence of cerebral stroke, including ischemic infarction and intracranial hemorrhage (ICH), increases in patients with nephrotic syndrome (NS). However, the clinical characteristics of patients with NS and stroke remain elusive. We aimed to investigate the clinical presentation and prognosis among patients with NS and ischemic stroke (IS) or ICH. Methods We conducted a population-based retrospective cohort study of patients with NS and acute stroke using the Chang Gung Research Database of Taiwan from January 1, 2001, to December 31, 2017. The participants were recruited from the 7 branches of Chang Gung Memorial Hospital. Results A total of 233 patients with IS and 57 patients with ICH were enrolled. The median age was 60 (52–70) years. The prevalence rates of hyperlipidemia, hyperuricemia, and smoking were higher in IS than in ICH. IS demonstrated lower white blood cell count (7.80 vs. 8.92 × 109/L) and high-sensitivity C-reactive protein level (33.42 vs. 144.10 nmol/L) and higher cholesterol (5.74 vs. 4.84 mmol/L), triglyceride (1.60 vs. 1.28 mmol/L), and albumin (24 vs. 18 g/L) levels compared with ICH. The dependent functional status and 30-day mortality were higher in ICH than in IS. The risk factors for 30-day mortality for patients with NS and stroke were coronary artery disease (CAD), ICH, and total anterior circulation syndrome. The multivariate Cox regression analysis revealed that CAD was positively associated with 30-day mortality in patients with IS (hazard ratio 24.58, 95 % CI 1.48 to 408.90). In patients with ICH, CAD and subarachnoid hemorrhage were positively associated with 30-day mortality (hazard ratio 5.49, 95 % CI 1.54 to 19.56; hazard ratio 6.32, 95 % CI 1.57 to 25.53, respectively). Conclusions ICH demonstrated a higher risk of dependence and 30-day mortality compared with IS in patients with NS. Intensive monitoring and treatment should be applied particularly in patients with NS and ICH.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characteristics of ischemic stroke and intracranial hemorrhage in patients with nephrotic syndrome

et al. 2021

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“…According to a recent study, out of 10461 patients with nephrotic syndrome, 15 had acute cerebral damage, and D-dimer levels were increased in 13 out of those 15 patients. Coagulopathy was observed in 9 out of the 15 patients 56 . In a study of 100 nephrotic syndrome patients, it was observed that 53 out of 100 had elevated D-dimer levels 57 .…”

Section: Pre-existing Thrombophilic Disorders and Covid-19mentioning

confidence: 96%

Hematologic parameters in coronavirus infection (COVID-19) and their clinical implications

Waleed¹,

Sehar²,

Iftikhar³

et al. 2020

Discoveries (Craiova)

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Coronaviruses are a class of enveloped RNA viruses that cause infections of the respiratory tract, characterized by fever, tiredness, dry cough, diarrhea, loss of smell or taste, chest pain and shortness of breath. Many patients with mysterious pneumonia were distinguished in December 2019 in Wuhan. The pneumonia of obscure origin was found to be ascribed to a novel coronavirus and described as novel coronavirus pneumonia (NCP). The Chinese authorities initially reported the wave of mysterious pneumonia on December 31st, 2019 and it was declared as an outbreak of international concern on January 30th, 2020. A systematic search of relevant research was conducted, and a total of 58 primary research articles were identified, analyzed, and debated to better understand the hematologic profile in COVID-19 (Coronavirus disease) infection and its clinical implications. All the findings in this article manifest a true impression of the current interpretation of hematological findings of the SARS-COV-2 disease. Pathophysiology of COVID-19 disease can be better interpreted by taking into consideration the hematologic parameters. Clinical implications of the hematologic profile of COVID-19 patients including cytokine storm, coagulation profile, and thrombophilic complications are under-recognized. Therefore, this review focuses on the coagulation profile, cytokine storm, and its treatment options. The role of pre-existing thrombophilia in COVID-19 patients and how it could result in the poor prognosis of the disease is also debated. The recent data suggests that hypercoagulability could be the potential cause of fatalities due to COVID-19. Potential effects of tocilizumab, metronidazole, and ulinastatin in suppressing cytokine storm may help to treat SARS-COV-2 infection. This review also highlights the significance of thrombophilia testing in SARS-CoV-2 patients depending on the clinical features and especially in pregnant women.

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Relapse of nephrotic syndrome with unusual thromboembolic event: A case report

Pournasiri,

Hashemi,

Ahmadizadeh

et al. 2023

Clinical Case Reports

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Key Clinical MessageMost children with nephrotic syndrome heal without any sequelae. However, rare life‐threatening complications such as thromboembolism may occur in pediatric nephrotic syndrome and should be considered in those with a new‐onset neurologic deficit.AbstractThe thromboembolism (TE) as a complication of nephrotic syndrome (NS) is rare and serious, and may involve renal, cerebral, pulmonary, or peripheral venous and/or arterial thrombosis. Here, we describe a 4.5‐year‐old male with a history of nephrotic syndrome, who developed hemorrhagic stroke in the territory of middle cerebral artery (MCA).

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Clinical Features of Nephrotic Syndrome with Cerebral Hemorrhage

Cited by 8 publications

References 33 publications

Characteristics of ischemic stroke and intracranial hemorrhage in patients with nephrotic syndrome

Characteristics of ischemic stroke and intracranial hemorrhage in patients with nephrotic syndrome

Hematologic parameters in coronavirus infection (COVID-19) and their clinical implications

Relapse of nephrotic syndrome with unusual thromboembolic event: A case report

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