Clinical features of multiple sclerosis in the south of Brazil: a partial analysis

Finkelsztejn, Alessandro; Cristovam, Rafael do Amaral; Moraes, Gisele Silva de; Lopes, Mariah Graziani de Souza Mello; Silva, Aline Vitali da; Garcia, Márcio Severo; Cola, Caroline Miotto Menegat; Bastiani, Carlos Eduardo; Ferreira, Lisia Barros; Costa, Amanda Lucas da; Schneider, Silvete Maria Brandão; Frison, Thirzá Baptista

doi:10.1590/s0004-282x2009000600021

Cited by 20 publications

(21 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The age average and the first outbreak average of patients, the average disease duration in years, the average number of outbreaks, the average of the EDSS global score, as well as the predominance of RR are consistent with the literature [2][3][4][5]10,24,26 . The diagnosis time in years was greater than the Swedish study Skoog et al 27 , in which the time was two years, while in this study it was 3.9 years.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Clinical and epidemiological profile of patients diagnosed with multiple sclerosis in João Pessoa, Paraíba, Brazil

Negreiros

Sousa-Muñoz

Oliveira

et al. 2015

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Prevalence rates of multiple sclerosis (MS) suggest an interrelationship between genetic and environmental factors, ranging worldwide.Objectives Clinical and epidemiological characterization of MS patients in João Pessoa, Paraíba city.Methods Study involving patients treated in five services in the city.Results It included 87 patients with MS, representing a prevalence of 12.0 cases/100,000 population, mainly women (77%) and white people (66.7%) with mean age of 43 years and average age of the first outbreak of 32.2 years. Motor symptoms (65.5%) and relapsing-remitting clinical form (78.2%) predominated; the average of the Expanded Disability Status Scale (EDSS) scores was 3.5 and 72% used a type of immunomodulatory drug. There was a positive correlation between the number of outbreaks and the duration of the disease with EDSS scores.Conclusions The prevalence of the disease is considered average. The clinical and epidemiological characteristics are in line with most similar Brazilian studies.

show abstract

Section: Discussionsupporting

confidence: 89%

“…White ethnicity was predominant, corroborating most epidemiological studies in Brazil 2,3,4,5,10,24,25,26 , except for the study of Ferreira et al 6 , in which 93.2% were mixed race (African descent). In this respect, classifying patients according to their ethnicity in a country with great miscegenation as Brazil is not an easy task.…”

Section: Discussionsupporting

confidence: 80%

Clinical and epidemiological profile of patients diagnosed with multiple sclerosis in João Pessoa, Paraíba, Brazil

Negreiros

Sousa-Muñoz

Oliveira

et al. 2015

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…Yet, most investigations have focused on clinical description of hospital-based or MS Centers cohorts in different parts of the country [9][10][11][12][13][14][15][16] . Other studies have concentrated on the association with HLA 17, 18 , the influence of ethnic factors on the phenomenological presentation of the disease 19 ; the neuropsychological aspects of the disease 20,21 and the impact of the disease on patients' quality of life 22 .…”

mentioning

confidence: 99%

The prevalence of multiple sclerosis in Belo Horizonte, Brazil

Lana-Peixoto

Frota

Campos

et al. 2012

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a demyelinating inflammatory and degenerative disease of the central nervous system (CNS) whose etiology is still unknown. Epidemiological studies have suggested that the interaction between genetic susceptibility and a variety of environmental factors may play a key role accounting for the differences in its prevalence in distinct populations 1 .In the last few decades, a large number of studies have demonstrated the frequency of MS in all continents 2 . Unfortunately, however, many of these epidemiological studies lack consistent methodological features, such as strict diagnostic criteria, well defined study populations or geographical areas, and complete case ascertainment 3 . Such faults have rendered their results unreliable for comparisons with established data from other geographical areas 2,3 . In Latin America, surveys on the epidemiology of MS are still scanty and most of them exhibit these methodological limitations [4][5][6][7][8] .Interest in the study of MS in Brazil has markedly increased in the last few years. Yet, most investigations have focused on clinical description of hospital-based or MS Centers cohorts in different parts of the country [9][10][11][12][13][14][15][16] . Other studies have concentrated on the association with HLA 17,18 , the influence of ethnic factors on the phenomenological presentation of the disease 19 ; the neuropsychological aspects of the disease 20,21 and the impact of the disease on patients' quality of life 22 .Three papers on the prevalence of MS in well-defined geographical areas in Brazil have been so far published. The first study, in São Paulo city, considered 1990 as the prevalence year and showed a prevalence rate of 4.3 per 100,000 inhabitants 23 . A re-evaluation of this prevalence rate by the same senior author 24 took 1997 as the prevalence year and, through the use of aBstract Investigations on the prevalence rates of multiple sclerosis (MS) around the world have yielded important clues on the interplay between genetic susceptibility and environmental factors. As Brazil is a huge country laid on many latitudes and inhabited by population with distinct ethnic backgrounds, it might be assumed that the frequency of MS varies in its different regions. Objective: To determine the prevalence rate of MS in Belo Horizonte, the capital of the State of Minas Gerais, Southeastern Brazil. Methods: We used six sources to draw up a provisional list of identified cases of MS. Only patients with diagnosis of clinically definite MS according to Poser Committee criteria were included. Results: The calculated crude MS prevalence was 18.1/100,000 inhabitants. Conclusions: The MS prevalence in Belo Horizonte is similar to that found in São Paulo and Botucatu, two other cities in southeastern Brazil with similar ethnic background.Key words: multiple sclerosis, prevalence, Belo Horizonte, Southeastern Brazil.resumo Estudos sobre as taxas de prevalência da esclerose múltipla (EM) no mundo têm fornecido importantes evidências do papel da inter-relaçã...

show abstract

“…Studies show that in Brazil, the prevalence is 15 cases per 100 thousand inhabitants, being more frequent in the south and southeast of the country (6,7).…”

Section: Introductionmentioning

confidence: 99%

Assessment of patients with multiple sclerosis according to tests of the Multiple Sclerosis Functional Composite

2016

View full text Add to dashboard Cite

show abstract

Clinical features of multiple sclerosis in the south of Brazil: a partial analysis

Cited by 20 publications

References 14 publications

Clinical and epidemiological profile of patients diagnosed with multiple sclerosis in João Pessoa, Paraíba, Brazil

Clinical and epidemiological profile of patients diagnosed with multiple sclerosis in João Pessoa, Paraíba, Brazil

The prevalence of multiple sclerosis in Belo Horizonte, Brazil

Assessment of patients with multiple sclerosis according to tests of the Multiple Sclerosis Functional Composite

Contact Info

Product

Resources

About