Clinical features of macrophage activation syndrome in the adult northern Chinese population

Abstract

MAS in adults may not be as rare as was once thought, although the clinical features of MAS in adults often differ from those seen in children. The MAS mortality in adults is far higher than that for children. A diagnosis of MAS should be considered when a patient with rheumatic disease presents with prolonged high fever, peripheral cytopenia and liver failure. Collection of bone marrow aspirates is critical for accurate diagnosis and MAS therapy should begin as early as possible.

Lead removal from aqueous solutions by 732 cation‐exchange resin

“…Thus, this work aims to study the ion exchange characteristics of Pb 2þ with 732-CR in H þ form, including kinetics, mechanisms, isotherms, and thermodynamics, in a batch mode in order to validate its practical application in laboratories [20] and industry wastewater [21] treatment, especially at high concentrations. The kinetic data were described by different kinetic models: the Nernst-Planck equation and unreacted-core model (UCM).…”

A fatal case of systemic lupus erythematosus complicated by macrophage activation syndrome, portal vein thrombosis and acute colitis

“…Dear Editor, Systemic lupus erythematosus (SLE) may be associated with a wide variety of complications. 1 Macrophage activation syndrome (MAS) is a severe, potentially lifethreatening systemic condition. It has been described in association with systemic juvenile idiopathic arthritis (sJIA), SLE and Kawasaki disease.…”

“…It has been described in association with systemic juvenile idiopathic arthritis (sJIA), SLE and Kawasaki disease. 1 The mechanism is excessive proliferation and activation of T lymphocytes and macrophages leading to secretion of toxic levels of proinflammatory cytokines. 2 Diagnosis is based on the following criteria: persistent fever, splenomegaly, cytopenias involving at least two cell lines, hypertriglyceridemia and/or hypofibrinogenemia, hyperferritinemia and hemophagocytosis in the bone marrow.…”

“…3 In contrast, the incidence of MAS in SLE is about 0.9-4.6%, although it has been increasingly reported, especially in association with juvenile SLE. 1,7 A few reports also describe MAS associated with Sj€ ogren's syndrome. 1,6 The major hematological manifestations of SLE are anemia, leukopenia, thrombocytopenia and antiphospholipid syndrome.…”

Síndrome de ativação macrofágica: diferenças clínicas e laboratoriais entre pacientes com lúpus eritematoso sistêmico juvenil versus adulto

“…Esta complicação tem sido descrita no LESP e LESA. Entretanto não existem critérios diagnósticos validados para a SAM no lúpus e, desta forma, esta manifestação pode ser subdiagnosticada nestes pacientes 24,31,32,33 .…”