Clinical features of human T lymphotropic virus type 1-associated uveitis in Hokkaido, Japan

Kase, Satoru; Namba, Kenichi; Iwata, Daiju; Ohno, Shigeaki; Ishida, Susumu

doi:10.1007/s10384-013-0244-x

Cited by 11 publications

(6 citation statements)

References 29 publications

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“…The most frequently reported HTLV-1associated ocular disease is HU (Kamoi and Mochizuki, 2012b). Ophthalmologists have reported on HU from Hokkaido to Kyushu, with cases described from all over Japan (Mochizuki et al, 1992b;Goto et al, 1994;Kawamoto and Hayasaka, 1994;Ohba et al, 1994a,b;Ishioka et al, 1995;Takahashi et al, 2000;Miyanaga et al, 2009;Kase et al, 2013;Terada et al, 2017a). As for other areas of the world, clinical research into HU has been reported from the United States (Beilke, 1995), Martinique (Merle et al, 1996), Britain (Sandy et al, 1996), and Brazil (Yamamoto et al, 1999).…”

Section: Htlv-1 Carriers and Ocular Diseasementioning

confidence: 99%

HTLV-1 in Ophthalmology

Kamoi

2020

Front. Microbiol.

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Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus described as a causative agent for human disease. In the field of ophthalmology, a close relationship between HTLV-1 infection and uveitis was identified through a series of clinical and laboratory studies in the late 1980s-1990s. Since then, HTLV-1-related ocular manifestations such as keratoconjunctivitis sicca, interstitial keratitis, optic neuritis and adult T-cell leukemia/lymphoma (ATL)-related ocular manifestations have continuously been reported. During the three decades since the association between HTLV-1 and ocular pathologies was discovered, ophthalmic practice and research have advanced with the incorporation of new technologies into the field of ophthalmology. Accordingly, new findings from recent research have provided many insights into HTLV-1-associated ocular diseases. Advanced molecular technologies such as multiplex polymerase chain reaction (PCR)/broad-range PCR using ocular samples have enabled rapid and accurate diagnosis. Advanced ophthalmic technologies such as widefield fundus camera and optical coherence tomography (OCT) have clarified various features of HTLV-1-associated ocular manifestations, and identified characteristics such as the "knob-like ATL cell multiple ocular infiltration" (KAMOI) sign. Advanced drug delivery methods such as intravitreal injection and sub-Tenon injection have led to progress in preventing disease progression. This article describes global topics and the latest research findings for HTLV-1-associated ocular diseases, with reference to a largescale nationwide survey of ophthalmologists. Current approaches and unmet needs for HTLV-1 infection in ophthalmology are also discussed.

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Section: Htlv-1 Carriers and Ocular Diseasementioning

confidence: 99%

HTLV-1 in Ophthalmology

Kamoi

2020

Front. Microbiol.

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“…Human T lymphocyte virus type 1 (HLTV-1) is human retrovirus that targets CD4 lymphocytes of the adaptive immune system 15,16 . Transmission occurs via sexual contact, blood transfusion, and through breast milk 17 .…”

Section: Htlv-1 Associated Uveitismentioning

confidence: 99%

“…HTLV-1 is highly endemic in certain areas of the world including Southern Japan, the Caribbean, and central Africa. 15,18 . Inflammation is caused by intraocular infiltration of HTLV-1 infected T cells, viral gene expression, and release of cytokines including IL-6 15,19 .…”

Section: Htlv-1 Associated Uveitismentioning

confidence: 99%

“…HAU occurs most frequently in middle-aged women and generally has a favorable visual prognosis 15 . Yamaguchi et al demonstrated a significant association between seropositivity for HTLV-1 and Graves Disease.…”

Section: Htlv-1 Associated Uveitismentioning

confidence: 99%

“…While intermediate uveitis is the most common presentation, anterior uveitis and panuveitis can also occur. Retinal vascular changes including vasculitis and neovascularization are uncommon 15,22 . It is most often a unilateral process but can be bilateral in 43% 18 .…”

Section: Htlv-1 Associated Uveitismentioning

confidence: 99%

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