Clinical features of Guillain–Barré syndrome and factors associated with mortality during the 2019 outbreak in Peru

Reyes-Vega, Mary; Cabezas, Mirtha Gabriela Soto; Soriano-Moreno, Anderson N.; Valle-Campos, Andree; Aquino-Peña, Francisco; Flores-Jaime, Noemi; Ordóñez-Ibargüen, Luis A.; Martel, Kevin S.; Munayco, Cesar V.

doi:10.1007/s00415-022-11331-4

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…36,37 Risk Factors for Mortality Mortality in GBS most often occurs as respiratory or cardiac complications of the disease; 3 to 7% of patients die from the disease. [38][39][40] Risk of death is, not surprisingly, higher among patients requiring mechanical ventilation, with a mortality rate of 20% in this patient population. 7,25,39 The greatest percentage of patients actually die during the recovery phase of the disease, most often from respiratory or cardiovascular complications, highlighting the need for continued supportive care and monitoring even in later stages of the disease.…”

Section: Predicting Need For Mechanical Ventilationmentioning

confidence: 95%

Neuroprognostication: Guillain–Barré Syndrome

Traub,

Chaudhry

2023

Semin Neurol

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Guillain–Barré syndrome is an immune-mediated disease of the peripheral nerves characterized by rapidly progressing symmetric weakness, areflexia, and albuminocytological dissociation. Most patients reach their nadir within 2 weeks. Disease severity can be mild to severe, with 20% of patients requiring mechanical ventilation. Intravenous immunoglobulin and plasma exchange are equally effective treatments. Monitoring strength, respiratory function, blood pressure, and heart rate, as well as pain management and rehabilitative therapy are important aspects of management. About 20% of patients require assistance to walk at 6 months. Older age, preceding diarrhea, and lower Medical Research Council (MRC) sum scores predict poor outcome. Death from cardiovascular and respiratory complications can occur in the acute or recovery phases of the illness in 3 to 7% of the patients. Risk factors for mortality include advanced age and disease severity at onset. Neuropathic pain, weakness, and fatigue can be residual symptoms; risk factors for these include axonal loss, sensory involvement, and severity of illness.

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Section: Predicting Need For Mechanical Ventilationmentioning

confidence: 95%

Neuroprognostication: Guillain–Barré Syndrome

Traub,

Chaudhry

2023

Semin Neurol

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“…2023;84(4):441-447. 443 Siete de los 10 casos de SGB de este reporte refieren haber tenido un cuadro infeccioso previo, esto coincide con estudios de brotes previos en el Perú (71,4%) (13) , y revisiones mundiales de SGB (14) . Solo 2 pacientes reportaron antecedente epidemiológico de enfermedad diarreica previa, es probable que el espectro clínico de las infecciones asociadas a SGB vaya desde casos sintomáticos hasta asintomáticos, como también se encuentra en otros reportes en Perú, como el descrito por Raet al que describe que solo un 49% presentaron diarrea y 27% una infección del tracto respiratorio superior (15) .…”

Section: Características Clínicas Y Laboratoriales Pacientes Con Guil...unclassified

Características clínicas y laboratoriales de los diez primeros pacientes con diagnóstico de Guillain-Barré en Piura, 2023

Pampa-Espinoza,

Mendoza Farro,

Flores-León

et al. 2023

An Fac med

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El síndrome de Guillain Barré es una enfermedad derivada del compromiso en las neuronas del sistema nervioso periférico por una respuesta descontrolada del sistema inmune que conduce daño axonal y/o desmielinización. El objetivo de este reporte fue describir los 10 primeros casos sospechosos de Síndrome de Guillain Barré en Piura. Se logró identificar la presencia de Campylobacter jejuni en las muestras de heces del 80% de los pacientes reportados. Es muy importante reconocer rápida y oportunamente al paciente con diagnóstico sospechoso de Guillain Barré, y realizar los estudios necesarios en un brote para identificar los agentes desencadenantes del cuadro.

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Clinical features of Guillain–Barré syndrome and factors associated with mortality during the 2019 outbreak in Peru

Cited by 2 publications

References 20 publications

Neuroprognostication: Guillain–Barré Syndrome

Neuroprognostication: Guillain–Barré Syndrome

Características clínicas y laboratoriales de los diez primeros pacientes con diagnóstico de Guillain-Barré en Piura, 2023

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