Clinical Features of Febrile Urinary Tract Infection Caused by          Extended-spectrum Beta-lactamase-producing &lt;i&gt;Escherichia Coli&lt;/i&gt; in          Children

Ohnishi, Takuma; Mishima, Yoshinori; Takizawa, Shohei; Tsutsumi, K.; Amemiya, Atsuko; Akiyama, Nobuko; Kanna, Yukiko; Asato, Shinya; Tomita, Mizue; Ikemiyagi, Masako; Shikoro, Nobuaki; Nakazawa, M.; Kurihara, Nobuyoshi; Kamimaki, Isamu

doi:10.2302/kjm.2019-0005-oa

Cited by 4 publications

(3 citation statements)

References 11 publications

(15 reference statements)

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“…History of surgical procedures did not increase the risk of ESBL-pE infection (OR 2.0; 95%CI: 0.89-4.392; p=0.096). This study confirmed a very high prevalence of ESBL-pE UTI in this hospital (56,4% in 2018 and 62.9% in 2019) compared to other hospitals in other countries which ranged from 9% to 42% [9][10][11][12]. This condition is not very surprising because the antibiotic use in Indonesia is high, with a higher proportion of antibiotic use was without indication [13][14][15], and the thirdgeneration cephalosporines were the most frequently prescribed in most Indonesian hospitals [16].…”

Section: Resultssupporting

confidence: 86%

Untitled

2023

J. Med. Chem. Sci.

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The third-generation cephalosporins have been very widely used in Indonesia, raising concerns about the increase of infections caused by multidrug resistance organisms, in particular the extended-spectrum βlactamase-producing Enterobacteriaceae (ESBL-pE). Dr. Kariadi Hospital (DKH), Semarang, Indonesia, implemented the policy of ceftriaxone restriction since November 2018. This study aimed to describe the prevalence of urinary tract infections (UTI) caused by ESBL-pE during 2018 -2019, the origin of the ESBL-pE strains, the risk factors of developing ESBL-pE UTI, and the antibiotic options for ESBL-pE UTI paediatric patients. Methods. A retrospective cross-sectional study was performed by collecting data from microbiology laboratory and medical records of paediatric patients hospitalized with UTI in DKH, from January 2018 to December 2019. Statistical analysis was performed using Chi-square or Fisher-exact test. Results: UTI was microbiologically confirmed in 318. Enterobacteriacea caused UTI in 86 (59%) patients, of these 56.4% (in 2018) dan 62.9 (in 2019) were ESBL-pE strains. E. coli and K. pneumoniae were the most common etiology of UTI. ESBL-pE was isolated from 42% UTI patients from the community and from 76% UTI patients referred from other hospitals (p <0.01). Most strains were susceptible to amikacin, meropenem, and fosfomycin with a tendency of lower susceptibility in 2019 than in 2018 (p>0.05) Conclusion: The UTI incidence caused by ESBL-pE in DKH was high. Patients referred from other hospitals were important source of ESBL-pE UTI, underlining the urgency to perform surveillance and to implement the infection control and prevention measures in addition to the antibiotic stewardship program.

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Section: Resultssupporting

confidence: 86%

Untitled

2023

J. Med. Chem. Sci.

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“…Previously, there have not been any multicenter studies in Japan on the clinical characteristics of pediatric fUTI. Although Japanese pediatricians use data from the United States and Europe as a clinical reference, it was pointed out by a single-center study that Japan may have a different sex ratio and age distribution for fUTI compared to other countries (Ohnishi et al, 2019). This study aimed to address this issue by clarifying the clinical characteristics of fUTI in Japanese children.…”

Section: Introductionmentioning

confidence: 98%

Clinical characteristics of pediatric febrile urinary tract infection in Japan

Ohnishi

Mishima

Matsuda

et al. 2021

International Journal of Infectious Diseases

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Background: Febrile urinary tract infection (fUTI) is the most common serious bacterial infection in children. Despite this, there have been no studies examining the clinical features of pediatric fUTI in Japan. The purpose of this study was to describe the clinical characteristics of fUTI in Japanese children. Methods: A multicenter, retrospective, observational study was conducted at 21 hospitals in Japan. Children under the age of 15 years who were diagnosed with fUTI between 2008 and 2017 were included. The diagnostic criteria were a temperature over 38 C and the presence of a single bacterial pathogen in urine culture. Patient characteristics were obtained from medical records. Results: In total, 2,049 children were included in the study. The median age was 5 months, and 59.3% were male. It was found that 87.0% of the males and 53.2% of the females were under 1 year of age. The main causative pathogens identified were Escherichia coli and Enterococcus spp., accounting for 76.6% and 9.8% of infections, respectively.

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“…11 Urinary tract infections caused by AMR E. coli and skin and soft tissue infections caused by community-acquired methicillinresistant S. aureus are emerging issues in Japanese children. 12,13 Intractable otitis media caused by multidrug resistant Streptococcus pneumoniae and Haemophilus influenzae have also arisen as problems in the clinical setting. 14 In the following sections, we summarize the problems with AMR and the efforts to address them in children in Japan.…”

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confidence: 99%

Measures Against Antimicrobial Resistance in Children in Japan: Current Status and Future Prospects

Kusama

Ishiwada

2022

Pediatric Infectious Disease Journal

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Quoted from the Glossary of Antimicrobial Chemotherapy (Japanese Society of Chemotherapy), the Annual Report of the Japanese Society of Antimicrobials for Animals 36 (2014), and the Guidelines for the Use of Antimicrobial Substances in Cooperative Livestock Insurances (2009, Ministry of Agriculture, Forestry and Fisheries)[Reference] There are multiple relevant terminologies with different definitions. However, in medical practice, the following four terms are often used interchangeably to refer drugs that act against bacteria: "antimicrobial agents," "antibiotics," "antibiotic agents," and "antibacterial agents." In the areas of agriculture and livestock, the expressions "antibacterial agents" and "antimicrobial agents" are commonly used, because these agents are not only used for therapeutic purposes, but also in antibiotic feed additives.Antimicrobial agents or antimicrobials: Antimicrobial agents, or antimicrobials, are active against microorganisms, which are generally categorized into bacteria, fungi, viruses and parasites. These are the general term for drugs to treat and prevent infectious diseases. They contain antibacterial agents, antifungal agents, antiviral agents and antiparasitic agents. Antibacterial agents: Antimicrobial agents that are active against bacteria. Antibiotics: informally defined as an agent that is derived from living organisms to inhibit and control cell activities of microorganisms Antibiotic agents: Another term for drugs that use the antibacterial action of antibiotics Reference: the Manual of Antimicrobial Stewardship, 1st edition * Prepared from [3] with partial modification. JVARM "Results of Monitoring of Antimicrobial Resistant Bacteria Isolated from Food-producing Animals on Farms" ** Target values were quoted from [1].

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Clinical Features of Febrile Urinary Tract Infection Caused by Extended-spectrum Beta-lactamase-producing <i>Escherichia Coli</i> in Children

Cited by 4 publications

References 11 publications

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Clinical characteristics of pediatric febrile urinary tract infection in Japan

Measures Against Antimicrobial Resistance in Children in Japan: Current Status and Future Prospects

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