Clinical features of demyelinating optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibody in Chinese patients

Zhao, Ying; Tan, Shaoying; Chan, Tommy C Y; Xu, Quangang; Zhao, Jie; Teng, Da; Fu, Heyun; Wei, Shihui

doi:10.1136/bjophthalmol-2017-311177

Cited by 85 publications

(79 citation statements)

References 30 publications

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“…Previous studies have shown that MOG-Abs are prevalent in younger patients (4–8 years) with encephalopathy, while older patients (13–18 years) present almost exclusively with ON 20. Our previous study21 reported the onset in MOG-ON occurs at a younger age than AQP4-ON (range: 5–63 years vs 8–72 years, respectively). However, this study was biased by a mixed population that included both adults and children.…”

Section: Discussionmentioning

confidence: 69%

Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China

et al. 2018

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Section: Discussionmentioning

confidence: 69%

Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China

et al. 2018

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“…26 In addition, bilateral simultaneous optic neuritis was seen in 37% of patients, which is similar to what has been reported in other studies. 5,6,14,27 Bilateral optic neuritis is also more common in AQP4-IgG-associated optic neuritis but less common in MS-associated optic neuritis. 21,24,28 …”

Section: Discussionmentioning

confidence: 99%

Myelin Oligodendrocyte Glycoprotein Antibody–Positive Optic Neuritis: Clinical Characteristics, Radiologic Clues, and Outcome

Chen

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Jitprapaikulsan

et al. 2018

American Journal of Ophthalmology

298

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“…Jitprapaikulsan et al 22 conducted a cross-sectional cohort study analyzing 246 recurrent optic neuritis patients at the Mayo Clinic between 2000 and 2017 and reported an AQP4-Abepositive rate of 19% and MOG-Abepositive rate of 13%. In a study of 109 patients with demyelinating optic neuritis in China, 45 patients (41.3%) showed AQP4-Abepositive results and 20 patients (18.3%) showed MOG-Abepositive results, with a mean age at onset of 35.6AE15.7 years in the AQP4-Abepositive optic neuritis group and 20.2AE17.4 years in the MOG-Abepositive optic neuritis group, 23 showing a higher AQP4-Abepositive rate and a tendency of younger onset compared with our findings. However, a study from Denmark of 51 patients with acute optic neuritis reported that 20 patients demonstrated MS at follow-up, none showed positive results for AQP4-Ab, and 2 showed positive results for MOG-Ab.…”

Section: Rates Of Antieaquaporin-4 Antibodye and Antiemyelin Oligodenmentioning

confidence: 99%

Epidemiologic and Clinical Characteristics of Optic Neuritis in Japan

et al. 2019

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Purpose: To elucidate the clinical and epidemiologic characteristics of optic neuritis in Japan. Design: Multicenter cross-sectional, observational cohort study. Participants: A total of 531 cases of unilateral or bilateral noninfectious optic neuritis identified in 33 institutions nationwide in Japan. Methods: Serum samples from patients with optic neuritis were tested for antieaquaporin-4 antibodies (AQP4-Abs) and antiemyelin oligodendrocyte glycoprotein antibodies (MOG-Abs) using a cell-based assay and were correlated with the clinical findings. Main Outcome Measures: Antibody positivity, clinical and radiologic characteristics, and visual outcome. Results: Among 531 cases of optic neuritis, 12% were AQP4-Ab positive, 10% were MOG-Ab positive, 77% were negative for both antibodies (double-negative), and 1 case was positive for both antibodies. Pretreatment visual acuity (VA) worsened to more than a median 1.0 logarithm of the minimum angle of resolution (logMAR) in all groups. After steroid pulse therapy (combined with plasmapheresis in 32% of patients in AQP4-Abepositive group), median VA improved to 0.4 logMAR in the AQP4-Abepositive group, 0 logMAR in the MOG-Abepositive group, and 0.1 logMAR in the double-negative group. The AQP4-Abepositive group showed a high proportion of females, exhibited diverse visual field abnormalities, and demonstrated concurrent spinal cord lesions on magnetic resonance imaging (MRI) in 22% of the patients. In the MOG-Abepositive group, although posttreatment visual outcome was good, the rates of optic disc swelling and pain with eye movement were significantly higher than those in the AQP4-Abepositive and double-negative groups. However, most cases showed isolated optic neuritis lesions on MRI. In the double-negative group, 4% of the patients had multiple sclerosis. Multivariate logistic regression analysis of all participants identified age and presence of antibodies (MOG-Ab and AQP4-Ab) as significant factors affecting visual outcome. Conclusions: The present large-scale cohort study revealed the clinicoepidemiologic features of noninfectious optic neuritis in Japan. Antieaquaporin-4 antibodyepositive optic neuritis has poor visual outcome. In contrast, MOG-Ab positive cases manifested severe clinical findings of optic neuritis before treatment, but few showed concurrent lesions in sites other than the optic nerve and generally showed good treatment response with favorable visual outcome. These findings indicate that autoantibody measurement is useful for prompt diagnosis and proper management of optic neuritis that tends to become refractory.

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Clinical features of demyelinating optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibody in Chinese patients

Abstract: MOG-ON is not rare in Chinese demyelinating patients. It underwent a severe vision loss at onset but had relatively better visual recovery than patients with AQP4-ON. MOG-ON might have an unique pathogenesis different from AQP4-ON.

Cited by 85 publications

References 30 publications

Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China

Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China

Myelin Oligodendrocyte Glycoprotein Antibody–Positive Optic Neuritis: Clinical Characteristics, Radiologic Clues, and Outcome

Epidemiologic and Clinical Characteristics of Optic Neuritis in Japan

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