Clinical features of crimean-congo haemorrhagic fever in the united arab emirates

Schwarz, Tino F.; Nsanze, H; Ameen, A. S.

doi:10.1007/bf01740819

Cited by 90 publications

(75 citation statements)

References 16 publications

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“…In cells that lack SKI-1, PreG N and PreG C accumulate in the Golgi apparatus, and infected cells secrete virus particles lacking surface glycoproteins (Bergeron et al, 2007). (Papa et al (2002c(Papa et al ( ) 1948(Papa et al ( -2000 Khazakhstan 108 35 Hoogstraal (1979) and Yashina et al (2003Yashina et al ( ) 1943Yashina et al ( -2010 Tajikistan 237 16 Asia-2 IV; M2 Hoogstraal (1979), Seregin et al (2004) and Ergonul (2010Ergonul ( ) 1976Ergonul ( -2000 Pakistan 23 39 Asia-1 IV; M1; M2; Asia-IV Burney et al (1980) and Smego et al (2004Smego et al ( ) 2011 India 6 83 Asia-2 IV; M2; Asia-IV Yadav et al (2013) Suleiman et al (1980), Schwarz et al (1997) and Watts et al (1989Watts et al ( ) 1990 Saudi Arabia 7 0 El-Azazy and Scrimgeour (1997Scrimgeour ( ) 1995Scrimgeour ( -1997 Oman 4 Asia-1 IV; M1; Asia-IV Saluzzo et al (1985Saluzzo et al ( ) 1979Saluzzo et al ( -1980 Iraq 55 Saluzzo et al (1985) and Nabeth et al (2004aNabeth et al ( , 2004bNabeth et al ( ) 1983 Burkina Faso 1 0 Watts et al (1989Watts et al ( ) 1981Watts et al ( -1986 South Africa 32 31 S Africa/W Africa-III; M1; M2 Watts et al (1989) Elata et al (2011) N-linked glycosylation of G N is also essential for the final processing of both glycoproteins (Erickson et al, 2007). G N performs a chaperone-like function for G C , and must be present for correct folding to occur (Shi et al, 2012).…”

Section: The M Segmentmentioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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Bente, Dennis A.; Forrester, Naomi L.; Watts, Douglas M.; McAuley, Alexander J.; Whitehouse, Chris A.; and Bray, Mike, "CrimeanCongo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity" (2013 b s t r a c tCrimean-Congo hemorrhagic fever (CCHF) is the most important tick-borne viral disease of humans, causing sporadic cases or outbreaks of severe illness across a huge geographic area, from western China to the Middle East and southeastern Europe and throughout most of Africa. CCHFV is maintained in vertical and horizontal transmission cycles involving ixodid ticks and a variety of wild and domestic vertebrates, which do not show signs of illness. The virus circulates in a number of tick genera, but Hyalomma ticks are the principal source of human infection, probably because both immature and adult forms actively seek hosts for the blood meals required at each stage of maturation. CCHF occurs most frequently among agricultural workers following the bite of an infected tick, and to a lesser extent among slaughterhouse workers exposed to the blood and tissues of infected livestock and medical personnel through contact with the body fluids of infected patients. CCHFV is the most genetically diverse of the arboviruses, with nucleotide sequence differences among isolates ranging from 20% for the viral S segment to 31% for the M segment. Viruses with diverse sequences can be found within the same geographic area, while closely related viruses have been isolated in far distant regions, suggesting that widespread dispersion of CCHFV has occurred at times in the past, possibly by ticks carried on migratory birds or through the international livestock trade. Reassortment among genome segments during co-infection of ticks or vertebrates appears to have played an important role in generating diversity, and represents a potential future source of novel viruses. In this article, we first review current knowledge of CCHFV, summarizing its molecular biology, maintenance and transmission, epidemiology and geographic range. We also include an extensive discussion of CCHFV genetic diversity, including maps of the range of the virus with superimposed phylogenetic trees. We then review the features of CCHF, including the clinical syndrome, diagnosis, treatment, pathogenesis, vaccine development and laboratory animal models of CCHF. The paper ends with a discussion of the possible future geographic range of the virus. For the benefit of researchers, we include a Supplementary Table listing all published reports of CCHF cases and outbreaks in the English-language literature, plus some principal articles in other languages, with total case numbers, case fatality rates and all CCHFV strains on GenBank.

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Section: The M Segmentmentioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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“…Similar to other tick-borne zoonotic agents, CCHFV normally circulates in nature unnoticed, causing symptomless infection in both ticks and animal vertebrates, both of which the virus life cycle relies upon (Ergö nü l, 2006). Human infection is characterized by a sudden febrile illness and in severe cases can progress to haemorrhagic fever manifestations with up to a 70% mortality rate (Schwarz et al, 1997). Despite the medical importance and severity of the disease, the molecular biology of CCHFV remains poorly understood, primarily because outbreaks are sporadic and its handling requires the highest containment facilities: biosafety level 4 (BSL-4).…”

Section: Introductionmentioning

confidence: 99%

Expression, purification and crystallization of the Crimean–Congo haemorrhagic fever virus nucleocapsid protein

Carter

Barr

Edwards

2012

Acta Crystallogr F Struct Biol Cryst Commun

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Crimean-Congo haemorrhagic fever virus (CCHFV) is a member of the Nairovirus genus within the Bunyaviridae family of segmented negative-sense RNA viruses. This paper describes the expression, purification and crystallization of full-length CCHFV nucleocapsid (N) protein and the collection of a 2.1 Å resolution X-ray diffraction data set using synchrotron radiation. Crystals of the CCHFV N protein belonged to space group C2, with unit-cell parameters a = 150.38, b = 72.06, c = 101.23 Å , = 110.70 and two molecules in the asymmetric unit. Circular-dichroism analysis provided insight into the secondary structure, whilst gel-filtration analysis revealed possible oligomeric states of the N protein. Structural determination is ongoing.

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“…16 Various fatality rates for CCHF, up to 80%, have been reported in the literature. 12,15,17 No CCHF virus IgM or IgG antibodies were detected in the serum specimens obtained from two of the fatal cases, but the virus was detected by PCR . The absence or minimal evidence of antibody response in the patients who died was reported previously.…”

Section: Discussionmentioning

confidence: 96%

Crimean-Congo Hemorrhagic Fever Virus Infection: Clinical and Laboratory Observations and Predictors of Fatality

Kadanalı¹,

Özden²,

Erol³

2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : In this study we described the predictors of fatality among Crimean-Congo hemorrhagic fever (CCHF) patients who admitted to our hospital based on epidemiological, clinical and laboratory findings between 2005 and 2006. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Definitive diagnosis was based on the detection of CCHF virus-specific IgM by ELISA and/or of genomic segments of the CCHF virus by real time polymerase chain reaction. Related data were collected prospectively. R Re es su ul lt ts s: : The study included 63 patients. Thirty-two of the patients (50.8%) were females and 31 of them (49.2%) were males. The overall case fatality rate was 4.8 %. The age and sex were similar between favorable and fatal cases (p>0.05). The mean duration to the onset of symptoms for all patients was 4.7 days and differences in the mean duration to the onset of symptoms between surviving and died patients were not statistically significant (p=0.22). Weakness, myalgia, somnolence, bleeding from multiple sites and presence of petechia/ecchymosis were observed more often in the patients who died (p=0.02, p=0.03, p=0.015, p=0.02, respectively). Significant elevation of LDH levels (p=0.004), prolonged APT (p=0.004), prolonged PT (p=0.04) and thrombocytopenia (p=0.01) were detected in patients who died. Oral ribavirin was prescribed to 46 patients (73%). Prescription of ribavirin was considered to three patients with fatal disease, but this could not be realized because of hematemesis and melena. C Co on nc cl lu us si io on n: : The existence of various clinical and laboratory findings like weakness, myalgia, somnolence, bleeding, elevation of LDH levels, prolonged APT and PT and thrombocytopenia may be considered as risk factors for fatality in CCHF. İyi olgularla ölümcül olgular arasında yaş ve cinsiyet benzerdi (p>0,05). Tüm hastalarda belirtiler ortaya çıkana kadar geçen ortalama süre 4,7 gündü ve hayatta kalan ve ölen hastalar arasında belirtiler ortaya çıkana kadar geçen süre bakımından istatistiksel olarak anlamlı fark yoktu (p=0,22). Güçsüzlük, myalji, uyku hali, birden fazla bölgeden kanama ve peteşi/ekimoz varlığı ölen hastalarda daha sık gözlendi (p=0,02, p=0,03, p=0,015, p=0,02). Ölen hastalarda LDH düzeylerinde önemli yük-selme (p=0,004), uzamış APT (p=0,004), uzamış PT (p=0,04) ve trombositopeni (p=0,01) saptandı. Kırkaltı hastada (%73) oral ribavirin verildi. Fatal üç hastaya ribavirin verilmesi düşünüldü fakat hematemez ve melena nedeniyle gerçekleştirilemedi. S So on nu uç ç: : Güçsüzlük, myalji, uyku hali, kanama, LDH düzeylerinde yükselme, uzamış APT ve PT, trombositopeni gibi çeşitli klinik ve laboratuvar bulgularının varlığı KKKA'da fatalite için risk faktörleri olarak düşünülebilir.A An na ah ht ta ar r K Ke el li im me el le er r: : Hemorajik ateş virüsü, kırım-kongo; tanı; keneler T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J M Me ed d S Sc ci i 2 20 01 12 2; ;3 32 2( (2 2) ): :4 43 32 2--7 7

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Clinical features of crimean-congo haemorrhagic fever in the united arab emirates

Cited by 90 publications

References 16 publications

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Expression, purification and crystallization of the Crimean–Congo haemorrhagic fever virus nucleocapsid protein

Crimean-Congo Hemorrhagic Fever Virus Infection: Clinical and Laboratory Observations and Predictors of Fatality

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