Clinical features of acute noroviral gastroenteritis in children : comparison with rotaviral gastroenteritis

Hwang, Pil-Joo; Kwak, Ji Hee; Lee, Taek Jin; Jeong, Su Jin

doi:10.3345/kjp.2009.52.4.453

Cited by 11 publications

(12 citation statements)

References 18 publications

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“…This result corresponds with previous studies that have demonstrated the similar symptoms of noroviral and rotaviral gastroenteritis, and that noroviral gastroenteritis has a milder course [20][21][22]. Leukocytosis (55.0%) and lymphocytosis (21.0%) were more frequently observed in the norovirus-infected group than in the rotavirus-infected group, again matching findings from a previous study [23]. For noroviral gastroenteritis cases, the clinical symptoms were milder than the laboratory findings.…”

Section: Discussionsupporting

confidence: 80%

A Clinico-Epidemiological Comparison Study of Pediatric Acute Viral Gastroenteritis at a Tertiary Care Hospital

Kim

Lee

2016

Ann Clin Microbiol

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Background: Acute viral gastroenteritis is a common illness in young children. Rotavirus, norovirus and enteric adenovirus are the major agents for viral gastroenteritis. Their detection rates have gradually increased in Korea. Our aim was to monitor the epidemiologic characteristics of the aforementioned viruses and to determine the laboratory and clinical characteristics of pediatric patients infected with these viruses. Methods: From December 2009 to November 2010, 685 stool specimens from patients hospitalized at Chung-Ang University Hospital were tested for the aforementioned viruses using multiplex PCR. A corresponding medical record review was retrospectively conducted. Results: The overall prevalence rate was 44.8%, with rates of 16.3%, 1.9%, 22.7%, 3.1%, and 0.8% for rotavirus, norovirus genogroup I, norovirus genogroup II, enteric adenovirus, and astrovirus, respectively.Mixed virus infections were detected in 37 patients (5.4%). The highest incidence rates occurred in March 2010 (18.9%), in the 13-24 month age group (38.1%), and in males (53.1%). Fever and chills were most frequently observed in patients with adenovirus (44.4%) than other viruses, while diarrhea was most frequently observed in patients with rotavirus (93.7%). Leukocytosis (55.0%) and lymphocytosis (21.0%) were more common in the norovirus-infected group than other viruses-infected group. Conclusion: Our results show different prevalence rates and clinical findings for each gastroenteritis-associated virus. To better understand the clinico-epidemiological features observed in this study, further epidemiologic and clinical investigations are needed.

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Section: Discussionsupporting

confidence: 80%

A Clinico-Epidemiological Comparison Study of Pediatric Acute Viral Gastroenteritis at a Tertiary Care Hospital

Kim

Lee

2016

Ann Clin Microbiol

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“…Hwang et al8) also reported leukocytosis in 4 cases (18.2%) of norovirus infection and 4 cases (8.9%) of rotavirus infection. Abnormal liver function test results were also observed in 14 cases (63.6%) of norovirus infection and 40 cases (88.9%) of rotavirus infection.…”

Section: Discussionmentioning

confidence: 93%

“…The signs and symptoms of norovirus infection were relatively mild compared to rotavirus infection. Hwang et al8) reported that mean duration of hospitalization was 3.9 and 4.2 days for rotavirus and norovirus infections, respectively and no significant differences were noticed in the frequency and duration of vomiting in these gastroenteritis. In our study, the difference in the mean duration of diarrhea between rotaviral (4.8 days) and noroviral (6.8 days) infections was statistically significant.…”

Section: Discussionmentioning

confidence: 98%

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Acute viral gastroenteritis in children hospitalized in Iksan, Korea during December 2010-June 2011

Kim

et al. 2013

Korean J Pediatr

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PurposeViral etiology is common in cases of children with acute diarrhea, and antibiotic therapy is usually not required. Therefore, it is important to determine the distribution of common viruses among children hospitalized with acute diarrhea.MethodsWe included 186 children who suffered from acute diarrhea and were hospitalized at the Wonkwang University Hospital Pediatric ward from December 1, 2010 to June 30, 2011 in this study. Stool samples were collected and multiplex reverse transcriptase polymerase chain reaction (multiplex RT-PCR) was used to simultaneously determine the viral etiology such as rotavirus, norovirus, astrovirus, or adenovirus.ResultsCausative viruses were detected in 72 of the 186 cases (38.7%). The mean age of the virus-positive cases was 1 year and 9 months (range, 1 month to 11 years). Rotavirus was detected in 50/186 (26.9%); norovirus, in 18/186 (9.7%); and astrovirus, in 3/186 cases (1.6%). Adenovirus was not detected in any of the cases. Proportions of norovirus genogroups I and II were 21.1% and 78.9%, respectively. Four of the 51 rotavirus-positive cases (7.8%) had received rotavirus vaccination at least once. The mean duration of diarrhea was 2.8 days (range, 1 to 10 days) and vomiting occurred in 39 of the 72 cases (54.2%).ConclusionViral etiology was confirmed in about one-third of the children with acute diarrhea, and the most common viral agent was rotavirus, followed by norovirus.

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“…Consistent with previous studies, clinical presentation of patient with AGE is not generally indicative of a pathogen. It has been reported that symptoms, the length of hospitalization, and the number of diarrhea episodes are not significantly different for the different infectious agents [27,33,36].…”

Section: Discussionmentioning

confidence: 98%

Detection of rotavirus and other enteropathogens in children hospitalized with acute gastroenteritis in Havana, Cuba

et al. 2015

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The aim of the study was to diagnose infections with rotavirus and other enteric pathogens in children under five years old with acute gastroenteritis and to identify the most common epidemiological and clinical characteristics of these pathogens. The study was conducted using 110 stool samples from the same number of children under five years old who were inpatients at three paediatric hospitals in Havana, Cuba, between October and December 2011. The samples were tested for rotavirus and other enteric pathogens using traditional and molecular microbiological methods. Pathogens were detected in 85 (77.3 %) of the children. Rotavirus was the most commonly found, appearing in 54.5 % of the children, followed by bacteria (29 %) and parasites (10.9 %). Other viral pathogens detected included adenovirus (6.4 %) and astrovirus (3.6 %). In rotavirus-positives cases, at least one other pathogen was detected, usually a bacterium (26.6 %). More than three episodes of watery diarrhea in 24 hours were observed in 78.3 % of the cases. Dehydration was found in 30 (50 %) rotavirus-positive children, of whom seven (11.6 %) were transferred to an intensive care unit due to complications of metabolic acidosis. Rotavirus was most commonly observed among children under 12 months old (65 %). The highest incidence of infection occurred in children who were under the care of a relative at home (78.3 %), had not been breastfed (65 %), or had been breastfed for less than six months (28.3 %). The genotype combinations most frequently found were G9P8 (28.3 %) and G1P8 (10 %). This study demonstrates the presence of rotavirus and other enteric pathogens as causes of gastroenteritis in hospitalized infants and young children in Cuba.

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Clinical features of acute noroviral gastroenteritis in children : comparison with rotaviral gastroenteritis

Cited by 11 publications

References 18 publications

A Clinico-Epidemiological Comparison Study of Pediatric Acute Viral Gastroenteritis at a Tertiary Care Hospital

A Clinico-Epidemiological Comparison Study of Pediatric Acute Viral Gastroenteritis at a Tertiary Care Hospital

Acute viral gastroenteritis in children hospitalized in Iksan, Korea during December 2010-June 2011

Detection of rotavirus and other enteropathogens in children hospitalized with acute gastroenteritis in Havana, Cuba

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