Clinical features of a new disease concept, IgG4-related thyroiditis

Abstract

Clinical features of a new disease concept, IgG4-related thyroiditis

IgG4‐related disease

“…Hypothyroidism is the major symptom. Although an increased volume of the thyroid is seen in cases of hypothyroidism, few cases show significant goiter . In addition, IgG4‐related hypothyroidism shows a favorable response to glucocorticoid therapy, in contrast to Hashimoto's disease .…”

Distribution of serum immunoglobulin G4 levels in Hashimoto’s thyroiditis and clinical features of Hashimoto’s thyroiditis with elevated serum immunoglobulin G4 levels

“…The thyroid function of these patients normalized after prednisolone treatment. The histology of their thyroid glands revealed IgG4-bearing plasma cells and loss of thyroid follicles; consequently, they were classified as having IgG4-related thyroiditis [3].…”

Cervical Lymph Nodes, Thyroiditis and Ophthalmopathy: The Pleomorphic Face of an Immunoglobulin G4-Related Disease

“…more than 40% of all infiltrating plasma cells were IgG4 positive, with very high IgG4-positive to IgG-positive plasma cell ratio of 0.87 [22]. There were no reasons to further extend the investigations, since liver tests were within the normal limits, biochemical data did not suggest the involvement of the gastrointestinal tract and the FDG-PET scan did not show a significant uptake in these sites.…”