Clinical features, diagnosis and therapy of pituicytoma: an update

Salge-Arrieta, Freddy J; Carrasco, Rodrigo; Rodríguez-Berrocal, Víctor; Pián, Héctor; Millán, J S Martínez-San; Iglesias, Pedro; Ley-Urzáiz, Luis

doi:10.1007/s40618-018-0923-z

Cited by 27 publications

(26 citation statements)

References 74 publications

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“…The number of cases reported in this study is currently the largest number reported by a single center. From the case data we reported, we did not observe a signi cant gender difference, which was slightly different from the larger number of male patients reported in a previous study [15]. Pituicytomas can occur at any age but are more common in middle-aged and elderly individuals [16].…”

Section: Epidemiology and Clinical Characteristicscontrasting

confidence: 81%

Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data

Cheng

Nie

et al. 2021

Preprint

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Background: Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis. Most studies of pituicytomas include only several cases. To better understand this disease, we reviewed a series of cases of pituicytomas. The diagnosis and treatment of pituicytoma must be further elucidated.Methods: Eleven patients with pituicytoma admitted to Beijing Tiantan Hospital from 2012 to 2019 were selected. The clinical features, including radiological and histological examination, surgical records and prognosis were reviewed. Sixty-eight other previously published cases of pituicytoma also were used to analyze the predictive factors for the results.Results: Our cohort included 4 males (36.37%) and 7 females (63.63%), with a mean age of 48.6 years. The tumor was located in the suprasellar region in 4 patients (36.37%), intrasellar region in 5 patients (45.45%), and intrasellar-suprasellar region in 2 patients (18.18%). All patients were misdiagnosed with other common tumors in the sellar region before the operation. During the operation, gross total resection of the tumor was achieved in 6 patients (54.55%), and subtotal resection was achieved in 5 patients (45.45%). The mean progression-free survival time was 33.72 months. Tumor progression after surgical resection occurred in 4 patients (36.37%). Among them, 72.73% of the patients with subtotal resection experienced progression, while 18.18% of the patients with gross total resection experienced progression. Combined with the 68 cases in the literature, gross total resection was an independent risk factor for progression-free survival time (P<0.05).Conclusion: Pituicytomas are more common in middle-aged people and in the sellar region. The clinical manifestations of pituicytomas are different, but no diagnostic clinical features have been identified other than an abnormally abundant blood supply. Currently, gross total resection is the best approach for the treatment of pituicytomas. More patients and longer follow-up periods were needed to further elucidate the biological features of pituicytomas.

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Section: Epidemiology and Clinical Characteristicscontrasting

confidence: 81%

Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data

Cheng

Nie

et al. 2021

Preprint

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“…The number of cases reported in this study is currently the largest number reported by a single center. From the case data we reported, there was no signi cant gender difference, which was slightly different from the larger number of male patients reported in the previous literature [15]. Pituicytomas can occur at any age but are more common in the middle-aged and elderly [16].…”

Section: Epidemiology and Clinical Characteristicscontrasting

confidence: 76%

Clinical Features, Radiological Profiles, Pathological Features and Surgical Outcomes of Pituicytomas: A Report of 16 Cases and a Pooled Analysis of Individual Patient Data

Cheng

Nie

Bin

et al. 2020

Preprint

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Background: Pituicytomas are rare neurogenic tumors of the sellar region.The diagnosis and treatment of pituicytoma needs to be further elucidated.Patients and Methods: This research included 16 patients with pituicytomas that were pathologically diagnosed in Tiantan Hospital from 2012 to 2019. And 68 other previously published cases of pituicytoma to analyze the predictive factors of the results.Results: Our cohort included 7 males (43.75%) and 9 females (56.25%), with a mean age of 49 years. The tumor was located in the suprasellar in 7 cases (43.75%), intrasellar in 6 cases (37.5%), and intrasellar-suprasellar mixed in 3 cases (18.75%). All patients were misdiagnosed with other common tumors in the sellar region before the operation. During the operation, gross total resection (GTR) of the tumor was achieved in 9 cases (56.25%) and subtotal resection (STR) in 7 cases (43.75%). The mean progression-free survival time (PFS) was 34.63 months. Tumor progression after surgical resection occurred in 5 patients (31.25%). Among them, 57.14% of the patients with STR had progression, while 11.11% of the patients with GTR had progression. Combined with 68 cases in the literature, it was found that GTR was an independent risk factor for PFS(P<0.05). Conclusions: Pituicytomas are more common in middle-aged people and the suprasellar region. The clinical manifestations of pituicytomas are different, there are no diagnostic clinical features, and its blood supply is abnormally abundant. Currently, GTR is the best approach for the treatment of pituicytomas.

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“…Pituicytomas are rare benign tumors, with only 117 cases in literature reported by a systematic review, 13 of which were treated with EETS. 41,42 Pituicytomas are known to be hypervascular, which can increase operative difficulties because of the risk of bleeding. [43][44][45] Given that more complex endoscopic surgeries have been shown to be associated with meningitis, 7 we speculate that these lesions may be more prone to infection.…”

Section: Tumor Characteristicsmentioning

confidence: 99%

Infectious Complications of Expanded Endoscopic Transsphenoidal Surgery: A Retrospective Cohort Analysis of 100 Cases

Lee

Cohen

Chan

et al. 2019

J Neurol Surg B Skull Base

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Objective To identify perioperative factors that may predict postoperative cerebrospinal fluid (CSF) leak and meningitis following expanded endoscopic transsphenoidal surgery (EETS). Study Design This is a retrospective study. This study was set at the Cedars-Sinai Medical Center, Los Angeles. A total of 78 patients who underwent EETS between January 2007 and November 2018 were participated. The main outcome measures were CSF leak and meningitis. Results A total of 78 patients underwent a total of 100 EETS procedures; 17.9 and 10.3% of patients developed postoperative CSF leaks and meningitis, respectively. Out of eight, three patients with meningitis did not develop an observable CSF leak. The risk of developing meningitis in patients with a CSF leak was significantly higher than those without a leak, with an odds ratio (OR) of 11.48 (95% confidence interval, 2.33–56.47; p = 0.004). Pituicytomas were significantly associated with meningitis compared with other pathologies. No other patient-specific factors were identified as risks for leak or meningitis, including method of skull base repair, sex, tumor volume, or body mass index, although there was a strong trend toward reduced CSF leak rates in patient with nasoseptal flaps used for skull base repair, compared with those without (9.5 vs. 25%). CSF protein was consistently elevated on the first CSF values obtained when meningitis was suspected. Conclusion CSF leak and meningitis are common complications of expanded endonasal surgery No statistically significant risk factors for developing a postoperative leak other than the pathology of pituicytoma were identified, including method of skull base repair, although the use of a vascularized nasoseptal flap did trend toward a reduced CSF leak rate. CSF protein is the most sensitive marker for the presumptive diagnosis and timely treatment of meningitis.

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Clinical features, diagnosis and therapy of pituicytoma: an update

Cited by 27 publications

References 74 publications

Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data

Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data

Clinical Features, Radiological Profiles, Pathological Features and Surgical Outcomes of Pituicytomas: A Report of 16 Cases and a Pooled Analysis of Individual Patient Data

Infectious Complications of Expanded Endoscopic Transsphenoidal Surgery: A Retrospective Cohort Analysis of 100 Cases

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