Clinical Features, Complications and Treatment Outcome of Childhood Brucellosis in Central Greece

Tsolia, Mariza; Drakonaki, Sophia; Messaritaki, A.; Farmakakis, Th.; Kostaki, Maria; Tsapra, Helen; Karpathios, T

doi:10.1053/jinf.2002.1000

Cited by 75 publications

(95 citation statements)

References 19 publications

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“…The present study describes the clinical features of brucellosis arthritis, as a common manifestation of the disease in children. The most common age group with arthritis was 8 to 12 years old, which is similar to that reported by previous studies 21314. About 16% of patients mentioned unpasteurized milk consumption, though a higher percentage (66.7%) of patients mentioned consumption of unpasteurized cheese.…”

Section: Discussionsupporting

confidence: 90%

“…The combination of oral co-trimoxazole for 6 weeks and intravenous gentamicin for 5 days was used for all patients. Different types of treatment were used in other studies,2417 but most used three drugs at least. For example combination of rifampin, doxycycline and co-trimoxazole2 or co-trimoxazole, streptomycin and rifampin was used for at least for 6 weeks 4.…”

Section: Discussionmentioning

confidence: 99%

“…Different types of treatment were used in other studies,2417 but most used three drugs at least. For example combination of rifampin, doxycycline and co-trimoxazole2 or co-trimoxazole, streptomycin and rifampin was used for at least for 6 weeks 4. Although the population size was small, the combination of mentioned drugs is an effective treatment for childhood brucellosis.…”

Section: Discussionmentioning

confidence: 99%

“…The disease is a typical zoonotic infection of domesticated and wild animals caused by organisms of genus Brucella . The infection occurs in humans by ingestion of animal milk or its products such as cheese, ice cream, butter, by direct contact with infected animals or inhalation of infectious aerosols 12…”

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confidence: 99%

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Epidemiological and clinical features of Brucella arthritis in 24 children

Zamani

Kooraki

Mohazab

et al. 2011

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:Brucellosis is considered the leading zoonotic disease of the Middle East. The disease has a wide spectrum of clinical manifestations and can result in complications with severe morbidity. The aim of this study was to evaluate the frequency, distribution and characteristics of arthritis in Iranian children with brucellosis.DESIGN AND SETTING:A retrospective descriptive study conducted in a referral children center in Tehran from 1997 to 2005.PATIENTS AND METHODS:Arthritis in children with brucellosis who were admitted to a specialized hospital was detected by clinical signs of the involved joint(s) and characteristics of joint fluid aspiration. Socio-demographic information was recorded.RESULTS:Of 96 patients diagnosed with brucellosis, 24 (25%) had Brucella arthritis 14 (58.3%) males and 10 (41.7%) females. Most common manifestations were fever in 21 patients (87.5%) and fatigue in 18 patients (75%). Monoarthritis was recorded in 15 patients (62.5%) of the cases with involvement of the knee in 8 (45%) and hip in 5 (29%), the ankle in 2 (8%) patients while 9 (37.5%) patients suffered from polyarthritis. None of the patients had axial joints involvement. Seventy-five percent of the subjects (18 patients) were from urban areas and 66.7% (16 patients) had consumed un-pasteurized cheese. Recurrence was not seen in any of the 24 patients who received a combination of co-trimoxazole for 6 weeks and gentamicin for 5 days.CONCLUSION:Childhood brucellosis is a challenging disease in Iran that has serious complications like arthritis. Therefore all physicians who work in endemic areas should be familiar with this disease and consider the possibility of brucellosis in all children who present with arthritis and arthralgia.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Epidemiological and clinical features of Brucella arthritis in 24 children

Zamani

Kooraki

Mohazab

et al. 2011

Annals of Saudi Medicine

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“…Although brucellosis in domestic animals has been controlled in most developed countries, it remains an important public and animal health problem in several parts of the world, including the Middle East (Tsolia et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalences and local variation of human and livestock brucellosis in two villages in Gharbia Governorate, Egypt

Sherbini

Kabbash

Schelling

et al. 2007

Transactions of the Royal Society of Tropical Medicine and Hygi

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SummaryThis study aimed at assessing the epidemiology of brucellosis among both human and livestock populations in an endemic area in Egypt. A cross-sectional survey was conducted in two villages, where 616 inhabitants (aged 3-75 years) and 350 livestock of 97 households were enrolled. Sera were tested for Brucella spp. antibodies by tube agglutination test for both populations. Proportions of seropositive sera were 0.0 and 1.7% among the inhabitants, and 0.0 and 16% among livestock of villages I and II, respectively. Calculated seroprevalences considering the clustering of brucellosis within households were 0.03 for people and 5.2 for livestock in village II. The village variable (P = 0.07) and keeping sheep in the household (P = 0.01) were significant risk factors for human brucellosis, whereas only the village was significant for livestock (P < 0.001). Sheep showed the highest seropositive proportions of brucellosis among livestock. No association could be detected between human and livestock brucellosis. In conclusion, we found local variation of seroprevalences of brucellosis among human and livestock in the two surveyed villages. Further epidemiological studies have to be conducted in randomly selected governorates, not only to confirm the low seroprevelance of human brucellosis, but also to assess the risk factors of livestock infection for terms of prophylaxis.

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Radiological Imaging of Spine Infection

Quintero¹,

Riascos²

2013

Diagnostic Imaging of Infections and Inflammatory Diseases

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Clinical Features, Complications and Treatment Outcome of Childhood Brucellosis in Central Greece

Cited by 75 publications

References 19 publications

Epidemiological and clinical features of Brucella arthritis in 24 children

Epidemiological and clinical features of Brucella arthritis in 24 children

Seroprevalences and local variation of human and livestock brucellosis in two villages in Gharbia Governorate, Egypt

Radiological Imaging of Spine Infection

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