Clinical features associated with drooling in Parkinson’s disease

Nascimento, David

doi:10.1007/s10072-020-05005-0

Cited by 7 publications

(8 citation statements)

References 60 publications

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“…Consequently, decreased salivary clearance due to oropharyngeal bradykinesia may be the major cause of drooling in PD patients 18,19 . A recent meta‐analysis suggested that the higher prevalence of drooling was related to various factors, such as disease severity, bradykinesia, dysphagia, dysarthria, and cognition 2 . However, fewer studies on the functional brain network of drooling in PD have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…It is a devastating and debilitating complication of Parkinson's disease (PD) that can be caused by excessive saliva production or swallowing dysfunction 1 . Drooling can occur at any stage of PD, with a prevalence ranging from 9.26 to 70% 2 . It may cause feelings, such as embarrassment, malodor, and skin infection, and further lead to a lack of self‐confidence, depression, and social isolation for PD patients.…”

Section: Introductionmentioning

confidence: 99%

“…More seriously, the accumulation of secretions in the oropharynx of PD patients considerably increases the risk of aspiration pneumonia, thereby contributing to the morbidity and mortality of aspiration pneumonia in PD patients 3 . Numerous researchers have recently focused on the prevalence of drooling, associated clinical symptoms, and treatment 2,4 . However, the cerebral mechanisms of drooling in PD remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“… 1 Drooling can occur at any stage of PD, with a prevalence ranging from 9.26 to 70%. 2 It may cause feelings, such as embarrassment, malodor, and skin infection, and further lead to a lack of self‐confidence, depression, and social isolation for PD patients. In addition to seriously reducing the quality of life of PD patients, these symptoms place a great burden on caregivers.…”

Section: Introductionmentioning

confidence: 99%

“… 3 Numerous researchers have recently focused on the prevalence of drooling, associated clinical symptoms, and treatment. 2 , 4 However, the cerebral mechanisms of drooling in PD remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Drooling disrupts the brain functional connectivity network in Parkinson's disease

et al. 2023

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AimsThis study aimed to investigate the causal interaction between significant sensorimotor network (SMN) regions and other brain regions in Parkinson's disease patients with drooling (droolers).MethodsTwenty‐one droolers, 22 PD patients without drooling (non‐droolers), and 22 matched healthy controls underwent 3T‐MRI resting‐state scans. We performed independent component analysis and Granger causality analysis to determine whether significant SMN regions help predict other brain areas. Pearson's correlation was computed between imaging characteristics and clinical characteristics. ROC curves were plotted to assess the diagnostic performance of effective connectivity (EC).ResultsCompared with non‐droolers and healthy controls, droolers showed abnormal EC of the right caudate nucleus (CAU.R) and right postcentral gyrus to extensive brain regions. In droolers, increased EC from the CAU.R to the right middle temporal gyrus was positively correlated with MDS‐UPDRS, MDS‐UPDRS II, NMSS, and HAMD scores; increased EC from the right inferior parietal lobe to CAU.R was positively correlated with MDS‐UPDRS score. ROC curve analysis showed that these abnormal ECs are of great significance in diagnosing drooling in PD.ConclusionThis study identified that PD patients with drooling have abnormal EC in the cortico‐limbic‐striatal‐cerebellar and cortio‐cortical networks, which could be potential biomarkers for drooling in PD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%