Clinical features and virological confirmation of perinatal dengue infection in Jambi, Indonesia: A case report

Abstract

The hyper-endemicity of dengue in Indonesia poses a significant threat of dengue virus (DENV) vertical transmission during pregnancy. A 29-year-old female at 38 weeks of pregnancy presented to hospital with acute fever and later confirmed with DENV infection. Due to signs of fetal distress, the neonate was delivered by emergency caesarean section. The mother developed a dengue critical phase post-caesarean with excessive bleeding and required blood transfusion. During the 6th day of life, the neonate was diagnosed and later confirmed with dengue. Next-generation sequencing of DENV RNA isolated directly from sera of both mother and neonate revealed identical DENV-2 whole-genome sequences. Plaque reduction neutralization test (PRNT) detected anti-dengue antibodies in both mother and neonate. Altogether, our data confirmed the occurrence of vertical transmission. Dengue vertical transmission during pregnancy may lead to severe manifestation, hence early diagnosis, close monitoring, and prompt intervention are critical.

Dengue neonatal: serie de casos**

“…Recalcamos que aunque sensibles y específicas las pruebas de antígenos, deberán ser corroboradas cuando se tiene la sospecha clínica. 28 De los casos reportados, la mayoría de los pacientes sintomáticos fueron tratados con antibióticos de amplio y muy amplio En México, se han realizado diversas publicaciones con reporte de casos y series de caso, uno de ellos en 2015, Romero Santacruz describe siete casos en neonatos de 34 a 40 semanas de gestación con antecedente de infección materna con diagnósticos por serología con IgM positivo, al igual que nuestros casos, con presencia de trombocitopenia y en uno de ellos con choque y hemorragia. 29 Arredondo García reporta que en el año 2019, los serotipos más frecuentes encontrados fueron DENV-1 y DENV-2, en nuestra serie, cuatro se reportan para DENV-2.…”

Dengue Encephalitis in a Newborn

“…Neonatal dengue has been reported in literature [1]. Denguerelated neurological complications have progressively been reported in pediatric and adult population [2].…”