Clinical features and varieties of non-motor fluctuations in Parkinson's disease: A Japanese multicenter study

Seki, Morinobu; Takahashi, Katsumi; Uematsu, Daisuke; Mihara, Ban; Morita, Yoko; Isozumi, Kazuo; Ohta, Kouichi; Muramatsu, Kazuhiro; Shirai, Tsuneo; Nogawa, Shigeru; Gotoh, Jun; Yamaguchi, Keiji; Tsutsumi, Yutaka; Yasutomi, Daisuke; Nihei, Yoshihiro; Iwasawa, Satoko; Suzuki, Noriyuki

doi:10.1016/j.parkreldis.2012.08.004

Cited by 50 publications

(42 citation statements)

References 19 publications

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“…The most common WO symptoms were motor symptoms, especially those correlated with bradykinesia (slowness, reduced dexterity) followed by tremor; among the non-motor symptoms the most frequent were the psychiatric ones, and these results are consistent with previous reports [14,20,21]. In accordance with other studies [14,22] we found a higher prevalence of fluctuating symptoms in subjects with longer disease duration, levodopa therapy, longer duration of levodopa therapy, more severe disease and in female gender ( Table 1).…”

Section: Discussionsupporting

confidence: 92%

Wearing-off detection in clinical practice: The wearing off real practice key (WORK-PD) study in Parkinson's disease

Altavista¹,

Cassetta²,

Brusa³

et al. 2015

Parkinsonism & Related Disorders

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Section: Discussionsupporting

confidence: 92%

Wearing-off detection in clinical practice: The wearing off real practice key (WORK-PD) study in Parkinson's disease

Altavista¹,

Cassetta²,

Brusa³

et al. 2015

Parkinsonism & Related Disorders

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“…Furthermore, the presence of NMF is underestimated on the domain level, because some symptoms within the NMSS domains occurred in both states while others were confined exclusively to Off states with variable distribution in individual subjects. However, on the item level we detected a high concordance between NMSS and WOQ-9 and NMSQuest frequencies within our cohort and in comparison to the large cohort investigated using the WOQ-9 as recently published by Seki and co-workers (Seki et al 2013). …”

Section: \0001supporting

confidence: 82%

“…NMF have been recognized as an important aspect of response oscillations and a major cause of morbidity and poor hr-QoL (Hillen and Sage 1996;Storch et al 2013;Witjas et al 2002), but they are often unrecognized and as such misunderstood (Seki et al 2013;Storch et al 2013;Witjas et al 2002). Since at least some NMF are potentially treatable with strategies that would affect fluctuations such as continuous dopaminergic stimulation (Chaudhuri et al 2013a), detection and management of NMF are of great importance for the treatment of fluctuating PD patients.…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of non-motor fluctuations in Parkinson’s disease using the Non-Motor Symptoms Scale (NMSS)

et al. 2015

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Data on frequency, severity and correlations of NMS with motor complications are only available for a limited number of NMS. The NMS Scale (NMSS) is a validated tool to assess a broad range of NMS, which has not been used in NMS fluctuations. We assessed fluctuations of a broad range of non-motor symptom (NMS) for a 1-month time period in fluctuating Parkinson's disease (PD) in a multicenter cross-sectional study using the NMSS assessing NMS in motor On (NMSSOn) and Off state (NMSSOff) combined with clinical NMS and motor function scoring in 100 fluctuating PD patients. ΔNMSSOn/Off was defined as the differences of NMSS scores between On and Off. Complete NMSS datasets were available from 73 patients (53 % men; age: 68.2 ± 9.7 years) with mean total NMSS score in On state of 41.5 ± 37.6 and in Off state of 75.6 ± 42.3 (P < 0.001). Scores were higher in Off compared to On state for all domains except for domain "perceptual problems/hallucinations" (P = 0.608). Clinimetric properties of the NMSS were similar to those reported previously for NMS assessments independent of motor oscillations. NMSSOn, NMSSOff and ΔNMSSOn/Off showed weak to moderate correlations with demographics, indicators of motor symptom severity as well as with other measures of NMS, depression and quality of life. Correlations of NMSS items/domains with independent measures of related constructs were weak to moderate. In conclusion, when assessed with the NMSS, a broad range of NMS fluctuate with motor oscillations, but these fluctuations do neither correlate with motor function nor with measures of disease progression.

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“…i.e. ; female sex, the onset of Parkinson symptoms before the age of and history of depression before IPD [23][24][25] . There was no statistically significant difference between sexes in terms of depressive symptoms (p=0.19).…”

Section: Discussionmentioning

confidence: 99%

The Assessment of Non-Motor Symptoms in Idiopathic Parkinson’s Disease

Genç¹,

Erdal²,

Gömceli³

et al. 2017

MMJ

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Clinical features and varieties of non-motor fluctuations in Parkinson's disease: A Japanese multicenter study

Cited by 50 publications

References 19 publications

Wearing-off detection in clinical practice: The wearing off real practice key (WORK-PD) study in Parkinson's disease

Wearing-off detection in clinical practice: The wearing off real practice key (WORK-PD) study in Parkinson's disease

Quantitative assessment of non-motor fluctuations in Parkinson’s disease using the Non-Motor Symptoms Scale (NMSS)

The Assessment of Non-Motor Symptoms in Idiopathic Parkinson’s Disease

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