Clinical features and the maternal and neonatal outcomes of pregnant women with coronavirus disease 2019

Abstract

BACKGROUNDThere is little information about the coronavirus disease 2019 during pregnancy.This study aimed to determine the clinical features and the maternal and neonatal outcomes of pregnant women with Covid-19. METHODSIn this retrospective analysis from five hospitals, we included pregnant women with Covid-19from January 1 to February 20, 2020. The primary composite endpoints were admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Secondary endpoints included the clinical severity of Covid-19, neonatal mortality, admission to neonatal intensive care unit (NICU), and the incidence of acute respiratory distress syndrome (ARDS) of pregnant women and newborns. RESULTSThirty-three pregnant women with Covid-19 and 28 newborns were identified. One (3%) pregnant woman needed the use of mechanical ventilation. No pregnant women admitted to the ICU. There were no moralities among pregnant women or newborns. The percentages of pregnant women with mild, moderate, and severe symptoms were 13 (39.4%),19(57.6%), and 1(3%). One (3.6%) newborn developed ARDS and was admitted to the NICU. The rate of perinatal transmission of SARS-CoV-2 was 3.6%. : medRxiv preprint CONCLUSIONSThis report suggests that pregnant women are not at increased risk for severe illness or mortality with Covid-19 compared with the general population. The SARS-CoV-2 infection during pregnancy might not be associated with as adverse obstetrical and neonatal outcomes that are seen with the severe acute respiratory syndrome coronavirus (SARS-CoV) andMiddle East respiratory syndrome coronavirus (MERS-CoV) infection during pregnancy.

Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis

“…In total, of 397 neonates born to mothers with COVID-19 infection in China, there were 8 who had a positive result for SARS-CoV-2 by NP swab resulting in a pooled proportion of 2.0% for vertical transmission. 8 , 9 , 10 , 11 , 26 , 56 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 The largest cohort study from China was by Yan et al, 11 in which 116 COVID-19–positive pregnant patients delivered 100 infants, of whom 86 underwent testing for SARS-CoV-2. None of the 86 infants had a positive result for COVID-19 via NP swab.…”

Knowledge and practice of preventive measures against COVID-19 infection among pregnant women in a low-resource African setting

“…04.15.20066894 doi: medRxiv preprint Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV), the case fatality rate appeared higher in women affected in pregnancy compared with non-pregnant women. 10 To curtail the continued spread of the coronavirus disease and its associated mortality, World Health Organisation has recommended series of preventive measures including regular hand washing with water and soap, social distancing, covering hand and mouth while coughing and avoiding touching eyes, nose and mouth. 11 In Nigeria, this preventive measures have been adopted to prevent further spread of the virus in the country.…”

Maternal and neonatal response to COVID-19

“…The most common symptom of COVID-19 in these women is fever, but many also experience cough, shortness of breath, and diarrhea. Occasionally severe infections required mechanical ventilation ( 2 , 13 , 14 , 24 , 27 , 30 , 46 ) but rarely led to death ( 13 ).…”