Clinical features and prognostic factors of pediatric idiopathic sudden hearing loss from moderate to profound degree

Wang, Yi; Ren, Tongli; Jing, Jianghua; Gao, Na; Zhao, Hui; Wang, Jing

doi:10.1016/j.amjoto.2021.103027

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…Chung et al performed a multivariate analysis of the prognostic factors of SSNHL and found that early treatment was associated with a good prognosis ( 6 ). Our study found that treatment onset time was an independent risk factor affecting the prognosis of SSNHL with the profound audiogram pattern, consistent with previous studies ( 2 , 9 , 27 ). This may be related to the microcirculation disorder of the inner ear.…”

Section: Discussionsupporting

confidence: 93%

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Clinical features and prognostic factors of children with profound sudden sensorineural hearing loss

Ling

Su²,

Liang³

et al. 2022

Front. Pediatr.

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ObjectiveTo investigate the clinical features and factors affecting the prognosis of children with profound sudden sensorineural hearing loss (SSNHL).MethodsWe retrospectively analyzed the clinical data of 147 children with profound SSNHL who received inpatient treatment at our department from January 2016 to January 2021. All children were administered with systemic steroid therapy and/or intratympanic steroid (ITS) treatment for 2 weeks. Statistical analyses were performed for the clinical features, treatment effectiveness, and factors affecting the prognosis using SPSS 23.0.ResultsThe median age of the study population was 8 (6–10) years. The median treatment onset time was 8 (4–20) days. The most common concomitant symptom was tinnitus (45.58%). Laboratory findings showed that the percentages of children with abnormal leukocytes was 25.85%, abnormal platelet counts was 17.01%, abnormal cytomegalovirus IgG antibodies was 36.73% and abnormal Epstein–Barr (EB) virus IgG antibodies was 41.50%. The overall recovery rate of the treatment was 20.04%. The univariate analysis showed that age, treatment onset time, tinnitus, and ITS treatment were associated with the prognosis (p < 0.05). Regarding laboratory findings, the neutrophil count, lymphocyte count, and neutrophil-to-lymphocyte ratio differed significantly between the effective and invalid treatment effect groups (p < 0.05). The multivariable logistic regression analysis showed that treatment onset time [odds ratio (OR) = 0.936, 95% confidence interval (CI): 0.881–0.994] and ITS treatment (OR = 0.174, 95% CI: 0.044–0.0687) correlated with hearing recovery (p < 0.05).ConclusionIn this study, the earlier the treatment start time of children with profound SSNHL, the better was the prognosis. Further, ITS could be an effective treatment option.

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Section: Discussionsupporting

confidence: 93%

“…Only 6.6%, 3.5%, and 1.2% of the patients with SSNHL are aged under 18 ( 6 ), 14 ( 7 ), and 9 years ( 8 ), respectively. In children, 55.3% of the cases of SSNHL are of profound hearing loss, and its effective treatment rate was found to be 31% ( 9 ). The profound SSNHL is the most severe form of hearing loss.…”

Section: Introductionmentioning

confidence: 99%

Clinical features and prognostic factors of children with profound sudden sensorineural hearing loss

Ling

Su²,

Liang³

et al. 2022

Front. Pediatr.

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“…The incidence of ISSNHL is ~5–20/100,000 people per year, and it has been gradually increasing with recent reports that younger populations are being affected ( 1 ). The percentage of patients with severe and profound hearing loss is ~41–74.2% ( 16 ). Unilateral severe to profound hearing loss inevitably affects a person's spatial hearing and speech recognition abilities, particularly in a long-term noise environment.…”

Section: Discussionmentioning

confidence: 99%

Abnormal posterior semicircular canal function may predict poor prognosis in patients with severe and profound ISSNHL

Yang

Gao

et al. 2023

Front. Neurol.

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BackgroundSevere and profound idiopathic sudden sensorineural hearing loss (ISSNHL) generally leads to unfavorable prognosis, and has a considerable impact on patient quality of life. However, related prognostic factors remain controversial.ObjectiveTo elaborate the relationship between vestibular function impairment and the prognosis of patients with severe and profound ISSNHL, and investigated the relevant factors affecting prognosis.MethodsForty-nine patients with severe and profound ISSNHL were divided into good outcome group [GO group, pure tone average (PTA) improvement > 30 dB] and poor outcome group (PO group, PTA improvement ≤ 30 dB) according to hearing outcomes. The clinical characteristics and the proportion of abnormal vestibular function tests in these two groups were analyzed by univariate analysis, and multivariable logistic regression analysis was performed for parameters with significant differences.ResultsForty-six patients had abnormal vestibular function test results (46/49, 93.88%). The number of vestibular organ injuries was 1.82 ± 1.29 in all patients, with higher mean numbers in PO group (2.22 ± 1.37) than in GO group (1.32 ± 0.99). Univariate analysis revealed no statistical differences between the GO and PO groups in terms of gender, age, side of the affected ear, vestibular symptoms, delayed treatment, instantaneous gain value of horizontal semicircular canal, regression gain value of vertical semicircular canal, abnormal rates of oVEMP, cVEMP, caloric test and vHIT in anterior and horizontal semicircular canal, however, significant differences were found in the initial hearing loss and abnormal vHIT of posterior semicircular canal (PSC). Multivariable analysis revealed that only PSC injury was an independent risk factor for predicting the prognosis of patients with severe and profound ISSNHL. Patients with abnormal PSC function had worse initial hearing impairment and prognosis than patients with normal PSC function. The sensitivity of abnormal PSC function in predicting poor prognosis in patients with severe and profound ISSNHL was 66.67%, specificity was 95.45%, and positive and negative likelihood ratios were 14.65 and 0.35, respectively.ConclusionAbnormal PSC function is an independent risk factor for poor prognosis in patients with severe and profound ISSNHL. Ischemia in the branches of the internal auditory artery supplying the cochlea and PSC may be the underlying mechanism.

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Analysis of hearing prognosis risk factors in pediatric unilateral sudden sensorineural hearing loss

Kim

Lee

et al. 2023

American Journal of Otolaryngology

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Clinical features and prognostic factors of pediatric idiopathic sudden hearing loss from moderate to profound degree

Cited by 7 publications

References 13 publications

Clinical features and prognostic factors of children with profound sudden sensorineural hearing loss

Clinical features and prognostic factors of children with profound sudden sensorineural hearing loss

Abnormal posterior semicircular canal function may predict poor prognosis in patients with severe and profound ISSNHL

Analysis of hearing prognosis risk factors in pediatric unilateral sudden sensorineural hearing loss

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