Clinical features and prognostic factors of adults with COVID-19 admitted to intensive care units in Colombia: A multicentre retrospective study during the first wave of the pandemic

Henríquez, Alberto; Accini, José; Baquero, Hernando; Molina, Francisco; Rey, Alejandro; Ángel, Victoria E.; Barraza, Ernest; Moreno-Bedoya, Sara; Maloof-Cuse, Dieb N.; Martínez-Diaz, Jorge I.; Cavadia, Germán; Viasus, Diego

doi:10.1016/j.acci.2021.02.001

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…Han Y et al performed a metatranscriptomic study in BAL uid from 19 patients with COVID-19 and 23 healthy controls and found a correlation between Rothia mucilaginosa and SARS-CoV-2, suggesting that it plays a role in the host's in ammatory response. We did not nd a correlation between Rothia and IL-1β; we previously described that patients with IL-1β levels < 1,365 pg/mL had increased mortality (12). The levels of only three cytokines, IFN-γ, GM-CSF and IL-17A, were correlated with the levels of some genera; however, we did not nd studies on COVID-19 with similar ndings.…”

Section: Discussioncontrasting

confidence: 67%

Deciphering the Lung Microbiota in COVID-19 patients: Insights from Culture Analysis, FilmArray Pneumonia Panel, Ventilation Impact, and Mortality Trends

Molina,

Botero,

Isaza

et al. 2024

Preprint

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Few studies have analyzed the role of the lung microbiome in the diagnosis of pulmonary coinfection in ventilated ICU COVID-19 patients. We characterized the lung microbiota in COVID-19 patients with severe pneumonia on invasive mechanical ventilation using full-length 16S rRNA gene sequencing and established its relationship with coinfections, mortality, and the need for mechanical ventilation for more than 7 days. This study included 67 COVID-19 ICU patients. DNA extracted from mini-bronchoalveolar lavage fluid and endotracheal aspirates was amplified by PCR with specific 16S primers (27F and 1492R). General and relative bacterial abundance analysis was also conducted. Alpha diversity was measured by the Shannon and Simpson indices, and differences in the microbiota were established using beta diversity. A linear discriminant analysis (LDA) effect size algorithm was implemented to describe biomarkers. Streptococcus spp. represented 51% of the overall microbial abundance. There were no differences in alpha diversity between the analyzed variables. There was variation in bacterial composition between samples that had positive and negative cultures. The genera Veillonella sp., Granulicatella sp., Enterococcus sp. and Lactiplantibacillus sp., with LDA scores > 2, were biomarkers associated with negative cultures. Rothia sp., with an LDA score > 2, was a biomarker associated with mortality.

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Section: Discussioncontrasting

confidence: 67%

Deciphering the Lung Microbiota in COVID-19 patients: Insights from Culture Analysis, FilmArray Pneumonia Panel, Ventilation Impact, and Mortality Trends

Molina,

Botero,

Isaza

et al. 2024

Preprint

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“…Although our patients were critical and mainly had COVID-19, mortality in patients with R . pickettii was higher than that reported in other studies conducted in COVID-19 patients (38%) (Henríquez et al, 2022). Importantly, mortality related to R .…”

Section: Discussioncontrasting

confidence: 65%

“…In the present study, comorbidities were documented in 79% of patients and the mortality rate was high (81%). Although our patients were critical and mainly had COVID-19, mortality in patients with R. pickettii was higher than that reported in other studies conducted in COVID-19 patients (38%) (Henríquez et al, 2022). Importantly, mortality related to R. pickettii bacteremia was 60% in our study.…”

Section: Discussioncontrasting

confidence: 63%

A large multicenter Ralstonia pickettii outbreak in critically ill patients during the COVID-19 pandemic: Epidemiological and clinical characteristics of 66 cases

Viana-Cárdenas,

Triana,

Cárdenas-Álvarez

et al. 2024

Journal of Infection Prevention

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Objective To describe a multicenter outbreak of R. pickettii that occurred in a large number of critically ill patients in a city in Colombia, during the COVID-19 pandemic. Methods In April 2021, the National Institute for Food and Drug Surveillance (INVIMA) reported an outbreak of R. pickettii infection associated with contaminated intravenous medications. The Municipal Health Department began collecting data for all cases identified by the hospitals and the results of microbiological studies. Medical records and death certificates of included cases were reviewed. Results Between March and May 2021, 66 cases of R. pickettii bloodstream infections from nine hospitals were documented. The median age of the patients was 60 years (IQR 51–72), and most of them had comorbidities (78.8%), mainly arterial hypertension and diabetes mellitus. At the time of the R. pickettii bloodstream infection, 89.4% had COVID-19, 86.4% were on mechanical ventilation, and 98.5% were receiving corticosteroids. The overall mortality was 81.8%. Nearly 60% of the deaths were related to R. pickettii bloodstream infections. R. pickettii was identified in the cultures from intravenous medications. Conclusions This large multicenter outbreak caused by intravenous medications contaminated with R. pickettii mainly affected critically ill COVID-19 patients. Mortality was high and largely related to R. pickettii bloodstream infection.

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Characteristics and outcomes of patients with COVID-19 in intensive care in the first year of the pandemic: A Colombian observational study

Díaz-Guio

Salazar-Ospina²,

Salazar-Palacio

et al. 2022

Acta Colombiana de Cuidado Intensivo

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Clinical features and prognostic factors of adults with COVID-19 admitted to intensive care units in Colombia: A multicentre retrospective study during the first wave of the pandemic

Cited by 7 publications

References 14 publications

Deciphering the Lung Microbiota in COVID-19 patients: Insights from Culture Analysis, FilmArray Pneumonia Panel, Ventilation Impact, and Mortality Trends

Deciphering the Lung Microbiota in COVID-19 patients: Insights from Culture Analysis, FilmArray Pneumonia Panel, Ventilation Impact, and Mortality Trends

A large multicenter Ralstonia pickettii outbreak in critically ill patients during the COVID-19 pandemic: Epidemiological and clinical characteristics of 66 cases

Characteristics and outcomes of patients with COVID-19 in intensive care in the first year of the pandemic: A Colombian observational study

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