Clinical features and prognosis of Reye's syndrome.

Reye's syndrome: assessment of intracranial monitoring.

“…Simultaneous recordings of arterial blood pressure and intracranial pressure suitable for analysis were available in 39 of 53 patients with Reye's syndrome aged [3][4][5][6] …”

Life-threatening intracranial hypertension in reye's syndrome treated with intravenous thiopentone

“…ports of Reye syndrome [3] but reluctance to monitor ICP at an early stage and to employ aggressive methods for its control [2,5] might be an alternative explanation.…”

“…In Britain the improvement has been less striking with a national mortality still in excess of 50% [3] although in individual centres it has been shown that better results can be achieved [2]. It is generally assumed that the ability to monitor intracranial pressure (ICP) has made a major contribution to this decline in mortality [1, 2] but direct evidence for this is lacking.…”

“…In Britain the improvement has been less striking with a national mortality still in excess of 50% [3] although in individual centres it has been shown that better results can be achieved [2]. It is generally assumed that the ability to monitor intracranial pressure (ICP) has made a major contribution to this decline in mortality [1,2] but direct evidence for this is lacking. We therefore report a case in which ICP reached systolic arterial level with cessation of electroencephalographic (EEG) activity and in whom brain death seemed inevitable but for timely reduction in ICP brought about by the administration of thiopentone.…”

“…Much of the evidence for the value of ICP monitoring [2,4] and the use of barbiturates to reduce ICP [2] is indirect. This case provides direct evidence of the benefit of ICP monitoring (and with it CPP and CFM) and the therapeutic use of intravenous thiopentone when more conventional methods of lowering ICP have failed.…”