Clinical features and prognosis-associated factors of non-small cell lung cancer exhibiting symptoms of bone metastasis at the time of diagnosis

Abstract

Abstract.The present study aimed to analyze the clinical characteristics and prognosis-related factors of non-small cell lung cancer (NSCLC) patients with bone metastases at the time of diagnosis. A total of 46 NSCLC patients with skeletal metastases at the time of diagnosis from Anhui Provincial Hospital and Anhui Provincial Cancer Hospital Affiliated to Anhui Medical University (Hefei, China) between February 2010 and February 2012 were investigated retrospectively. The median age was 58 years, with a range of 40-80 years, the ratio of males and females was 2:1, and adenocarcinoma and squamous cell carcinoma accounted for 71.7 and 28.3% of cases, respectively. Furthermore, 84.8% of patients exhibited multiple skeletal metastases at more than two sites and 54.3% of patients experienced skeletal-related events at the time of diagnosis. The median overall survival (OS) time of the patients was 237 days, and Kaplan-Meier analysis demonstrated that patients with adenocarcinoma (P=0.002), single bone metastases (P=0.023), an Eastern Cooperative Oncology Group performance status of 0-1 (P<0.001) or positive expression of estrogen receptor (ER)-β (P=0.039) exhibited significantly longer survival times. Furthermore, multivariate analysis identified the following independent predictors of OS: Tumor subtype (P=0.022), the number of bone metastases (P=0.016) and an ER-β-positive tumor (P=0.035). In the cohort of NSCLC patients with bone metastases at the time of diagnosis, adenocarcinoma and multiple skeletal metastases were most common.

Prognostic factors in patients with skeletal-related events at non-small-cell lung cancer diagnosis

“…Squamous cell carcinoma was found to be an independent risk factor for SREs at the time of NSCLC diagnosis. It has been reported that the frequency of distant metastases is higher in adenocarcinoma (3,16,17); there are discrepancies between those findings and the findings of the present study. It was also observed that the incidence rate of SREs was significantly higher in squamous cell carcinoma compared with that in adenocarcinoma patients at the time of NSCLC diagnosis.…”

“…Non-small-cell lung cancer NSCLC is the third most common cause of bone metastases following breast and prostate cancer (2). It has been reported that 84.8% of patients exhibit multiple skeletal metastases at the time of NSCLC diagnosis, which cause complications including bone pain, pathological fractures, spinal cord compression and dysmotility (3). There are differences in the prognosis of NSCLC patients with and without bone metastases (4,5).…”

“…There are differences in the prognosis of NSCLC patients with and without bone metastases (4,5). In addition, 54.3% of patients experience skeletal-related events (SREs) at the time of NSCLC diagnosis (3). SREs include radiotherapy, pathological fractures, spinal cord compression, orthopedic surgery and hypercalcemia.…”

Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity

“…ERβ has been investigated in numerous cancers including prostate, breast, kidney (Yu et al., 2013), colon (Dey et al., 2013), endometrium (Han et al., 2015), ovary (Ciucci et al., 2014, Suzuki et al., 2008) bladder (Hsu et al., 2013) and non-small cell lung cancer (He et al., 2015, Luo et al., 2015) but in many cases, the findings are predicated on non-specific reagents. As such, a re-evaluation of ERβ expression and biology is needed using reliable, specific reagents.…”

Метастазы В Позвоночник При Раке Легкого

“…При Оригінальні дослідження / Original Researches этом наиболее агрессивной гистологической формой РЛ считается мелкоклеточный гистологический ва-риант заболевания [16]. Вместе с тем среди больных РЛ с костными метастазами соотношение аденокар-циномы и плоскоклеточной карциномы (немелко-клеточных РЛ) составило 3 : 1 [10]. Как свидетельст-вует выполненный нами однофакторный дисперсион-ный анализ, метастатическое поражение костно-су-ставного аппарата связано с локализацией патологи-ческого процесса (D = 2,22; p = 0,039), формой забо-левания (центральная, периферическая) (D = 26,33; p < 0,001), некоторыми гистологическими варианта-ми РЛ (аденокарцинома, плоскоклеточная карцино-ма) (D = 26,33; p < 0,001) и наличием легочного ком-прессионного синдрома (D = 3,08; p = 0,005).…”