Clinical features and predictors of clinical outcomes in <scp>K</scp>orean patients with <scp>C</scp>rohn's disease: A <scp>K</scp>orean <scp>A</scp>ssociation for the <scp>S</scp>tudy of <scp>I</scp>ntestinal <scp>D</scp>iseases multicenter study

Moon, Chang Mo; Park, Dong Il; Kim, Eun Ran; Kim, Young Ho; Lee, Chang Kyun; Lee, Suck Ho; Kim, Jae Hak; Huh, Kyu Chan; Jung, Sung Ae; Yoon, Soon Man; Song, Hyun Joo; Jang, Hyun Joo; Kim, You Sun; Lee, Kang Moon; Shin, Jeong Eun

doi:10.1111/jgh.12369

Cited by 33 publications

(51 citation statements)

References 50 publications

(107 reference statements)

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“…In Asian populations, although prevalence of smoking is increasing, it remains less than it is in Europe [16] . Recent studies demonstrated an increased risk of complications in smokers compared to non-smokers in Hong Kong [17] and the need for surgery in Korea [18] .…”

Section: Impact Of Current Smoking On the Ibd Coursementioning

confidence: 99%

Smoking and Diet: Impact on Disease Course?

Cosnes¹

2016

Dig Dis

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Background: The impact of current smoking on inflammatory bowel disease (IBD) course has been studied extensively; smoking is deleterious in Crohn's disease (CD), and beneficial in ulcerative colitis (UC). Except for enteral nutrition, there are only limited data regarding the impact of diet on disease course. Key Messages: Current smoking worsens the course of CD, increasing the incidence of flares, the need for steroids, immunosuppressants and re-operations. Conversely, smoking cessation has a rapid beneficial effect on disease course, decreasing the risk of flares and of post-operative recurrences. From 3 months after the quit date, quitters have a disease course similar to that of never smokers. Achieving smoking cessation in CD is thus an important goal of therapy. On the contrary, smoking improves the course of UC and in particular, is associated with a decreased need for colectomy. Smoking cessation increases the risk of flare and the need for steroids or immunosuppressants. However, patients with UC should not be discouraged to quit, because the beneficial effect of smoking for their disease is counterbalanced by the deleterious systemic effects of tobacco. Among dietary interventions, only exclusive enteral nutrition was shown to induce remission and achieve mucosal healing in some patients with CD. The beneficial effect of liquid-defined diet is observed whatever be the type of administration (orally or by tube), the type of diet regarding protein and fat content and resulting alterations in the gut microbiota. In UC, enteral nutrition has no effect. Finally, popularized restrictive diets in IBD as the specific-carbohydrate diet and the gluten-free diet have not been rigorously tested. In a small trial, a semi-vegetarian diet was shown to be effective in maintaining remission over 2 years in CD. Conclusions: Patients with IBD should not smoke and avoid passive smoking. Aside from the defined liquid diets, there is no rationale for advising particular diets.

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Section: Impact Of Current Smoking On the Ibd Coursementioning

confidence: 99%

Smoking and Diet: Impact on Disease Course?

Cosnes¹

2016

Dig Dis

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“…According to a population-based study, the incidence ratio between males and females was 2.8:1, and a more recent multicenter study and nationwide cohort studies reported ratios of 2.5:1 and 2.8:1, respectively [3,10,19]. This differs from Western findings, which show a general female predominance [20,25,26].…”

Section: Epidemiologymentioning

confidence: 95%

“…Regarding disease behavior, B1 indicates nonstricturing and nonpenetrating, B2 indicates stricturing, and B3 indicates penetrating behaviors. In Korean CD, L3 is the most common (53% to 71%), followed by L1 (21% to 32%) and L2 (7% to 14%) [3,10,19]. A recent Chinese study showed a similar result (L1, 24%; L2, 6%; L3, 71%) [24].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…It has been reported that more than 10% of Western CD patients have a family history of IBD [15,20]. Previous Korean studies reported the frequency of family history in CD patients to be 1.4% to 2.9%, lower than Western levels [3,10,19,28]. …”

Section: Epidemiologymentioning

confidence: 99%

“…Since the 1960s, when the first CD case series were reported [6], to the early 2000s, most data on Korean CD have come from small, single-center studies. In the mid-2000s, however, Korean guidelines for the diagnosis and treatment of CD were prepared at the urging of the Korean Association for the Study of Intestinal Diseases (KASID), and many large-scale, multi-center studies have provided valuable information regarding the characteristic features of Korean CD [3,7,8,9,10,11]. Recently, a nationwide hospital-based CD cohort was launched.…”

Section: Introductionmentioning

confidence: 99%

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Crohn's disease in Korea: past, present, and future

Lee

2014

Korean J Intern Med

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The epidemiology, genetics, and clinical manifestations of Crohn's disease (CD) vary considerably among geographic areas and ethnic groups. Thus, identifying the characteristics of Korean CD is important for establishing management strategies appropriate for Korean patients. Since the mid-2000s, many studies have investigated the characteristic features of Korean CD. The incidence and prevalence rates of CD have been increasing rapidly in Korea, especially among the younger population. Unlike Western data, Korean CD shows a male predominance and a lower proportion of isolated colonic disease. Perianal lesions are more prevalent than in Western countries. Genome-wide association studies have confirmed that genetic variants in TNFSF15, IL-23R, and IRGM, but not ATG16L1, are associated with CD susceptibility in the Korean population. Studies of the associations between genetic mutations and the clinical course of CD are underway. Although it has been generally accepted that the clinical course of Korean CD is milder than that in Western countries, recent studies have shown a comparable rate of intestinal resection in Korean and Western CD patients. An ongoing nationwide, hospital-based cohort study is anticipated to provide valuable information on the natural history and prognosis of Korean CD in the near future.

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Inflammatory Bowel Diseases: How to Identify High-Risk Patients

Cosnes

Sokol

2017

Crohn's Disease and Ulcerative Colitis

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Clinical features and predictors of clinical outcomes in Korean patients with Crohn's disease: A Korean Association for the Study of Intestinal Diseases multicenter study

Cited by 33 publications

References 50 publications

Smoking and Diet: Impact on Disease Course?

Smoking and Diet: Impact on Disease Course?

Crohn's disease in Korea: past, present, and future

Inflammatory Bowel Diseases: How to Identify High-Risk Patients

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