Clinical Features and Possible Origin of Preretinal Deposits in Different Ocular Diseases and Events: A Narrative Review

Cheng, Yizhe; Chen, Chunli; Zhang, Zhihan; Peng, Xiaoyan

doi:10.1007/s40123-023-00674-4

Cited by 2 publications

(4 citation statements)

References 76 publications

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“…More importantly, they both have a preference for retinal vessels. However, PDs are still different from Kyrieleis plaques in the following ways ( 49 ). First, the imaging appearance of PDs is different from Kyrieleis plaques.…”

Section: Discussionmentioning

confidence: 99%

Case report: A rare appearance of preretinal deposits in a patient with uveitis: multimodal imaging observation

Cheng,

Chen,

Xiao

et al. 2023

Front. Med.

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BackgroundUveitis is a disease presenting with varied clinical symptoms and potentially devastates visual function. Here, we report a patient with uveitis exhibiting a rare appearance of preretinal deposits (PDs).Case presentationA 49-year-old female showed vitreous opacity and perivascular white PDs involving veins and arteries. The interferon-gamma release assay was strongly positive and chest computed tomography showed signs of calcified nodules; other tests were unremarkable. The patient was diagnosed with uveitis and tubercular infection. The patient was given systemic anti-tubercular therapy and steroids, which were subsequently combined with immunosuppressants. The shrinkage of HRD was more sensitively observed with OCT than on photographs during follow-up visits. The right eye was relieved subsequently, but the left eye showed vitreous opacity and responded poorly to the treatment. Three months after the dexamethasone intravitreal implant, the perivascular deposits in the left eye disappeared and the vitreous opacity was relieved.ConclusionPDs can appear as spotted deposits in the posterior pole and segmental deposits in the periphery in patients with uveitis, which mainly involves the vitreous cavity and is easily confused with retinal vasculitis. OCT can more sensitively observe the response than other examinations.

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Section: Discussionmentioning

confidence: 99%

Case report: A rare appearance of preretinal deposits in a patient with uveitis: multimodal imaging observation

Cheng,

Chen,

Xiao

et al. 2023

Front. Med.

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“…Purified and nonemulsified SO shows as hyporeflective on OCT scans,[ 104 ] whereas the reflectivity of the SO droplets is heterogeneous because of the different proportions within a given scan of emulsified SO droplets, fibrotic tissue, and inflammatory infiltrates, among others. [ 104 ]…”

Section: O Ptical C Oherence T ...mentioning

confidence: 99%

“…Histopathologic studies have proposed that intraocular inflammation is the main factor of droplet development, as there is histopathological evidence of macrophagic infiltrates, fibrosis, and silicone vacuoles within the basement membrane in samples of peeled ERM. [ 104 ]…”

Section: O Ptical C Oherence T ...mentioning

confidence: 99%

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Silicone oil emulsification: A literature review and role of widefield imaging and ultra-widefield imaging with navigated central and peripheral optical coherence tomography technology

Valentín-Bravo,

Stanga,

Reinstein

et al. 2024

Saudi Journal of Ophthalmology

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Silicone oil (SO) emulsification is a significant concern in vitreoretinal surgery, leading to various complications. Despite the high prevalence of SO emulsification within the eye, there is currently no standardized method for its early detection. The recent introduction of widefield (WF) imaging and ultra-WF (UWF) imaging with navigated central and peripheral optical coherence tomography (OCT) techniques have shown promising results in providing high-resolution images of the peripheral vitreous, vitreoretinal interface, retina, and choroid. This enhanced visualization capability enables the early identification of emulsified SO droplets, facilitating a proactive therapeutic approach, and mitigating associated adverse events. This comprehensive literature review aims to provide an updated overview of the topic, focusing on the role of WFimaging and UWF imaging and navigated central and peripheral swept-source OCT (SS-OCT) in the early detection and management of SO emulsification. The review discusses the current understanding of SO emulsification, its associated complications, and the limitations of existing detection methods. In addition, it highlights the potential of WF and UWF imaging and peripheral OCT as advanced imaging modalities for improved visualization of SO emulsification. This review serves as a valuable resource for clinicians and researchers, providing insights into the latest advancements in the field of vitreoretinal surgery and the promising role of WF imaging and UWF imaging and navigated central and peripheral SS-OCT in the management of SO.

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Clinical Features and Possible Origin of Preretinal Deposits in Different Ocular Diseases and Events: A Narrative Review

Cited by 2 publications

References 76 publications

Case report: A rare appearance of preretinal deposits in a patient with uveitis: multimodal imaging observation

Case report: A rare appearance of preretinal deposits in a patient with uveitis: multimodal imaging observation

Silicone oil emulsification: A literature review and role of widefield imaging and ultra-widefield imaging with navigated central and peripheral optical coherence tomography technology

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