Clinical Features and Outcomes of Severe Pneumonia Caused by Endemic Human Coronavirus in Adults

Abstract

In the context of the COVID-19 pandemic, we evaluated the clinical characteristics and outcomes of severe pneumonia caused by endemic human coronavirus compared with those caused by the influenza virus. To our knowledge, this study is the largest study based on a prospective cohort of severe endemic human coronavirus-associated pneumonia and may serve as a valuable resource in preparing for the post-pandemic period, considering that SARS-CoV-

Application of Alveolar Lavage Fluid Second-Generation Sequencing in the Treatment of Severe Pneumonia

“…Severe Pneumonia (SP) is a common respiratory critical disease in Intensive Care Unit (ICU), and its pathogens are mainly bacteria, as well as fungi, viruses and atypical pathogenic bacteria, etc. Its clinical symptoms are mostly fever, cough, sputum, shortness of breath, dyspnea and the course of the disease is mostly rapidly progressing, which can result in Acute Respiratory Distress Syndrome (ARDS), sepsis and eventually Multi-Organ Dysfunction Syndrome (MODS), with difficulty in treatment and high morbidity and mortality [1] . Although new modern medical technologies are constantly developing and improving and new antiinfective drugs are emerging, which are effective in SP caused by common bacterial infections, but at the same time, multi-drug resistant bacteria are increasingly available and the increase of infection with multi-drug resistant bacteria is continuously raising the difficulty of treatment, so the mortality rate of SP remains high [2] .…”