Clinical Features and Outcomes of Patients with Chemotherapy-induced Takotsubo Syndrome

Storey, Katelyn; Sharkey, Scott W.

doi:10.15420/usc.2019.10.1

Cited by 4 publications

(4 citation statements)

References 53 publications

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“…Other reported associations are with paclitaxel, trastuzumab, bevacizumab, and rituximab. 12 Both platins and taxanes are related to a variety of infusion-related reactions (IRR). The IRRs to paclitaxel can be IgE mediated, due to mast cell degranulation, or complement activation by Cremophor EL (compounded with paclitaxel).…”

Section: Discussionmentioning

confidence: 99%

A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion

Singh,

Ahmed,

Allen

et al. 2023

Journal of Investigative Medicine High Impact Case Reports

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Stress cardiomyopathy is a transient left ventricular dysfunction caused by physiologic or pathologic stressors. Anaphylaxis is a hypersensitivity disorder that can lead to a rapid life-threatening respiratory collapse. It happens due to exposure to allergens including medications. During anaphylaxis, there is a compensatory release of catecholamines that can lead to stress cardiomyopathy. In this case, nab-paclitaxel infusion led to anaphylaxis with respiratory failure. Echocardiogram showed features of diffuse hypokinesis with preserved basal segment contractility, and cardiac catheterization did not show any evidence of obstructive coronary artery disease. The overall clinical picture suggested stress cardiomyopathy. The patient was treated with guideline-directed medical therapy which resulted in normalization of the ejection fraction with no symptoms of congestive heart failure at any point. The patient was thereafter resumed on a reduced dose of nab-paclitaxel. This case report adds to the spectrum of infusion-related reactions associated with paclitaxel and demonstrates the course of events in the management of anaphylaxis and stress cardiomyopathy in this scenario.

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Section: Discussionmentioning

confidence: 99%

A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion

Singh,

Ahmed,

Allen

et al. 2023

Journal of Investigative Medicine High Impact Case Reports

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“…Rechallenging should be avoided if possible, particularly if the LVEF or GLS does not completely normalize ( 21 ). If it is inevitable or if the LVEF and GLS have normalized, rechallenging can be considered while maintaining patients on the cardioprotective treatments and with close surveillance ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Trigger related outcomes of takotsubo syndrome in a cancer population

Safdar

Ahmed²,

Liu³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundTakotsubo syndrome (TTS) occurs more frequently in cancer patients than in the general population, but the effect of specific TTS triggers on outcomes in cancer patients is not well studied.ObjectivesThe study sought to determine whether triggering event (chemotherapy, immune-modulators vs. procedural or emotional stress) modifies outcomes in a cancer patient population with TTS.MethodsAll cancer patients presenting with acute coronary syndrome (ACS) between December 2008 and December 2020 at our institution were enrolled in the catheterization laboratory registry. Demographic and clinical data of the identified patients with TTS were retrospective collected and further classified according to the TTS trigger. The groups were compared with regards to major adverse cardiac events, overall survival and recovery of left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) after TTS presentation.ResultsEighty one of the 373 cancer patients who presented with ACS met the Mayo criteria for TTS. The triggering event was determined to be “cancer specific triggers” (use of chemotherapy in 23, immunomodulators use in 7, and radiation in 4), and “traditional triggers” (medical triggers 22, and procedural 18 and emotional stress in 7). Of the 81 patients, 47 died, all from cancer-related causes (no cardiovascular mortality). Median survival was 11.9 months. Immunomodulator (IM) related TTS and radiation related TTS were associated with higher mortality during the follow-up. Patients with medical triggers showed the least recovery in LVEF and GLS while patients with emotional and chemotherapy triggers, showed the most improvement in LVEF and GLS, respectively.ConclusionCancer patients presenting with ACS picture have a high prevalence of TTS due to presence of traditional and cancer specific triggers. Survival and improvement in left ventricular systolic function seem to be related to the initial trigger for TTS.

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“…It has been suggested that chemotherapy accounts for 1-2% of TTS triggers (Storey & Sharkey 2019). Fluorouracil (5FU) is the most reported, though there are many others (Coen et al 2017).…”

Section: Key Pointmentioning

confidence: 99%

“…The onset of TTS relative to chemotherapy initiation is quite variable and may occur at any time from the initial administration to several weeks beyond initiation. TTS in the setting of treatment for malignancy is associated with substantial mortality (Storey & Sharkey 2019).…”

Section: Key Pointmentioning

confidence: 99%

Structural Heart Disease

Nicholson¹,

Hassan²,

Lotto³

et al. 2022

Cardiac Care

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Learning ObjectivesAfter reading this chapter and completing the learning activities, the reader will be able to: Describe cardiac conditions classed as acquired and hereditary structural heart disease  Discuss the relationship between rheumatic heart disease and valvular disease  Identify the most common forms of cardiomyopathy and their causes  Discuss the role of the nurse in a multidisciplinary team caring for patients with structural heart disease  Identify sources of information for patients with strutural heart disease and their families.

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Clinical Features and Outcomes of Patients with Chemotherapy-induced Takotsubo Syndrome

Cited by 4 publications

References 53 publications

A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion

A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion

Trigger related outcomes of takotsubo syndrome in a cancer population

Structural Heart Disease

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