Clinical features and outcomes of four HIV patients with COVID‐19 in Wuhan, China

Abstract

Serial chest computed tomography scans of four patients since symptom onset. (1) Patient A: (A and D) diffuse bilateral groundglass opacities (GGOs) predominantly involving perihilar and midzones with relative subpleural sparing at 3 weeks after symptom onset. (B and E) A mixed pattern of GGOs, reticulation and air space consolidation, cystic airspaces, decreased lung volume, and compensatory increased anteriorposterior chest diameter at 9 weeks. (C and F) Partial resolution of various lesions at 12 weeks. (2) Patient B: (A and D) diffuse irregular GGOs mainly with subpleural and peripheral involvement 10 days after symptom onset. (B and E) Confluence of peripheral lesions in the left upper lung and a mixed pattern of ground-glass and reticular opacities in the lower lung bilaterally at six weeks. (C and F) Lesion resolution with some remnant GGOs at 8 weeks. (3) Patient C: (A) irregular GGOs at the periphery of the lower lung bilaterally 4 weeks after symptom onset. (B) Enlarged areas of GGOs bilaterally and an irregular nodule in the right lower lung at 6 weeks. (C) minimal residual opaque lesions at eight weeks. (4) Patient D: (A) wedge-shaped GGOs at the periphery of the right upper lung and the left upper lung medially 2 days after symptom onset. (B) Enlarging area of GGOs bilaterally with reticulation and consolidation in the left lung at three weeks. (C) Partial resolution of GGOs at 5 weeks

SARS‐CoV‐2 infection in persons living with HIV: A single center prospective cohort

“…As a matter of fact, patients with a fatal outcome presented with lower CD4 counts, even if the difference was not statistically significant when analyzed according to a multivariate model. These findings confirm previously reported observations 6,15 …”

“…Most previous studies in PLWHIV concentrated on patients admitted to the hospital because of COVID‐19 6,8,15 . In our cohort, most of the included patients were not admitted to the hospital, testifying that, even in HIV‐positive subjects, SARS‐CoV‐2 may present as a mild diseases not requiring hospital admission or intensive care 16,17 .…”

“…These findings confirm previously reported observations. 6,15 Most previous studies in PLWHIV concentrated on patients admitted to the hospital because of COVID-19. 6,8,15 hospital admission or intensive care.…”

“…6,15 Most previous studies in PLWHIV concentrated on patients admitted to the hospital because of COVID-19. 6,8,15 hospital admission or intensive care. 16,17 As a matter of fact, the proportion of asymptomatic patients resulted quite high (18%).…”

New HIV diagnoses in patients with COVID-19: two case reports and a brief literature review

“…Maggiolo compared 55 cases of SARS-CoV-2 infection with 69 asymptomatic people living with HIV (PLHIV) negative for SARS-CoV-2 RT-PCR and/or serology, and suggested that HIVpositive individuals are not protected from SARS-CoV-2 infection or have a lower risk of severe disease and those with low CD4 + T cell counts might have worse outcomes [15]. Studies also suggested that HIV-positive individuals should not be considered to be protected from SARS-CoV-2 infection or to have lower risk of severe disease [16,17].…”