Clinical features and outcome of typhoid fever and invasive non-typhoidal salmonellosis in a tertiary hospital in Belgium: analysis and review of the literature

Yombi, Jean Cyr; Martins, Luzilma Terezinha Flenik; Vandercam, Bernard; Rodríguez-Villalobos, Hector; Robert, Annie

doi:10.1179/2295333715y.0000000016

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…NTS has been reported to be among the most common causes of bacteraemia in such settings (Bronzan et al, 2007;Feasey et al, 2012;Sothmann et al, 2015), mostly without symptoms of gastroenteritis (Feasey et al, 2012). In developed countries, and even in less-developed regions, NTS bacteraemia occurs in persons with immunosuppression and chronic comorbidities (Hohmann, 2001;Brown and Eykyn, 2000;Galofre et al, 1994;Yombi et al, 2015;Matheson et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Correlates of non-typhoidal Salmonella bacteraemia: A case–control study

Katz

Ben‐Chetrit

Sherer

et al. 2019

International Journal of Infectious Diseases

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A B S T R A C TObjective: Limited up-to-date evidence exists on host-related characteristics of non-typhoidal Salmonella (NTS) bacteraemia in high-income countries. Correlates of NTS bacteraemia in Israel were examined in this study. Methods: A case-control study was conducted using the medical records of patients hospitalized with NTS bacteraemia in Jerusalem during 1997-2016 (n = 106; 57 children, 49 adults). Two control groups were included: (1) randomly selected controls (n = 101), who were patients hospitalized due to bacteraemia with other pathogens; (2) patients with salmonellosis without bacteraemia (n = 112). Agestratified logistic regression models were constructed. Results: In children, a recent emergency room visit was associated with an increased likelihood of NTS bacteraemia. In adults, the likelihood of NTS bacteraemia versus salmonellosis increased in relation to Charlson comorbidity score (adjusted odds ratio (aOR) 1.29, 95% confidence interval (CI) 1.00-1.66, for each 1-point increase in the score), while an inverse association was found with haemoglobin level (aOR 0.72, 95% CI 0.54-0.95). Steroid therapy increased the likelihood of NTS bacteraemia compared to patients with bacteraemia due to other pathogens (aOR 5.22, 95% CI 1.01-26.93). Conclusions: In children, NTS bacteraemia was probably present at their prior emergency room visit. A high comorbidity burden increased the likelihood of bacteraemia in adults with Salmonella infection, while haemoglobin level might be protective.

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Section: Introductionmentioning

confidence: 99%

Correlates of non-typhoidal Salmonella bacteraemia: A case–control study

Katz

Ben‐Chetrit

Sherer

et al. 2019

International Journal of Infectious Diseases

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Salmonella, E. coli, and Citrobacter Type III Secretion System Effector Proteins that Alter Host Innate Immunity

Qaidi

Zhu

et al. 2018

Protein Reviews – Purinergic Receptors

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Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis

Marchello

Birkhold

Crump

2022

The Lancet Infectious Diseases

101

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Background Non-typhoidal salmonella can cause serious, life-threatening invasive infections involving the bloodstream and other normally sterile sites. We aimed to systematically review the prevalence of complications and case-fatality ratio (CFR) of non-typhoidal salmonella invasive disease to provide contemporary global estimates and inform the development of vaccine and non-vaccine interventions. MethodsWe did a global systematic review and meta-analysis of studies investigating the complications and mortality associated with non-typhoidal salmonella invasive disease. We searched Embase, MEDLINE, Web of Science, and PubMed for peer-reviewed, primary research articles published from database inception up to June 4, 2021, with no restrictions on language, country, date, or participant demographics. Only studies reporting the proportion of complications or deaths associated with non-typhoidal salmonella invasive disease, confirmed by culture of samples taken from a normally sterile site (eg, blood or bone marrow) were included. We excluded case reports, case series, policy reports, commentaries, editorials, and conference abstracts. Data on the prevalence of complications and CFR were abstracted. The primary outcomes were to estimate the prevalence of complications and CFR of non-typhoidal salmonella invasive disease. We calculated an overall pooled CFR estimate and pooled CFR stratified by UN region, subregion, age group, and by serovar when available with a random-effects meta-analysis. A risk-of-bias assessment was done, and heterogeneity was assessed with Cochran's Q Test, I², and τ². This study was done in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, and is registered with PROSPERO, CRD42020202293. FindingsThe systematic review returned a total of 8770 records. After duplicates were removed, 5837 titles and abstracts were screened, yielding 84 studies from 35 countries after exclusions. Of these included studies, 77 (91•7%) were hospital-based and 66 (78•6%) were located in Africa or Asia. Among 55 studies reporting non-typhoidal salmonella disease-associated complications, a total of 45 different complications were reported and 1824 complication events were identified among 6974 study participants. The most prevalent complication was septicaemia, occurring in 171 (57•2%) of 299 participants, followed by anaemia in 580 (47•3%) of 1225 participants. From 81 studies reporting the CFR of non-typhoidal salmonella invasive disease, the overall pooled CFR estimate was 14•7% (95% CI 12•2-17•3). When stratified by UN region, the pooled CFR was 17•1% (13•6-21•0) in Africa, 14•0% (9•4-19•4) in Asia, 9•9% (6•4-14•0) in Europe, and 9•6% (0•0-25•1) in the Americas. Of all 84 studies, 66 (78•6%) had an overall high risk of bias, 18 (21•4%) had a moderate risk, and none had a low risk. Substantial heterogeneity (I²>80%) was observed in most (15 [65•2%] of 23) CFR estimates. Interpretation Complications were frequent among individuals with non-typhoidal salmonella invasive disease ...

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Clinical features and outcome of typhoid fever and invasive non-typhoidal salmonellosis in a tertiary hospital in Belgium: analysis and review of the literature

Abstract: The clinical profile and outcome of TF patients are similar to those with iNTS. Although comorbidities are more often associated with iNTS, the results of our study suggest that clinical management of these two diseases should remain similar.

Cited by 4 publications

References 35 publications

Correlates of non-typhoidal Salmonella bacteraemia: A case–control study

Correlates of non-typhoidal Salmonella bacteraemia: A case–control study

Salmonella, E. coli, and Citrobacter Type III Secretion System Effector Proteins that Alter Host Innate Immunity

Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis

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