Clinical features and outcome of human Mpox (Monkeypox) in Saudi Arabia: An observational study of travel-related cases

Assiri, Abdullah M.; Al‐Tawfiq, Jaffar A.; Jokhdar, Hani; Algwizani, Abdullah; Albarraq, Ahmed M; Alanazi, Khalid H.; Alamri, Ahlam H.; Almohammadi, Emad L; Abuhasan, Musallam Yunus; Alserehi, Haleema; Rebh, Fatimah Zaki; Alrossais, Amirah; Alawad, Eman; AlBahrani, Salma

doi:10.1016/j.jiph.2023.01.006

Cited by 13 publications

(11 citation statements)

References 33 publications

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“…The first case of mpox in Saudi Arabia was detected on July 14, 2022, and as of May 23, 2023, a total of eight cases have been reported. Notably, the first seven cases were travel‐associated having a travel history of Europe and the Middle East 32 . Importations of mpox cases into Pakistan from Saudi Arabia can have implications on Pakistan's health system as the annual Islamic pilgrimage (Hajj) will be performed during June 26–July 1, 2023 whereby more than 179 000 pilgrims from Pakistan are expected to perform Hajj and return to Pakistan in July–August.…”

Section: Discussionmentioning

confidence: 99%

Genomic characterization of the first mpox and varicella‐zoster co‐infection in Pakistan (2023) through next‐generation sequencing

Umair,

Jamal,

Haider

et al. 2023

Journal of Medical Virology

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The global mpox outbreak spanning 2022–2023 has affected numerous countries worldwide. In this study, we present the first report on the detection, whole‐genome sequence, and coinfection of the mpox virus and varicella zoster virus (VZV) from Pakistan. During April–May 2023, samples from 20 suspected cases of mpox were tested at the National Institutes of Health, Islamabad among which 4 tested positive. All four cases had a travel history of Saudi Arabia. All the suspected samples were processed by using a Zymo research kit for DNA extraction, followed by qRT‐PCR amplification by using a DaAn Gene detection kit for the mpox virus. Further, two of the positive samples with a low Ct value (<20) were subjected to whole‐genome sequencing using a metagenomic approach on the iSeq (Illumina) platform. The sequencing results revealed Clade IIb and genotype A.2.1 of MPXV, which clustered with viruses from Slovenia and the UK in July and June 2022, respectively. Our analysis identified two novel nonsynonymous substitutions in mpox virus, namely V98I in OPG046 and P600S in OPG109. Furthermore, we successfully retrieved the complete genome of VZV from the same sample, belonging to Clade 5. This study represents the first positive case of MPXV in Pakistan and the coinfection of mpox and VZV by using a metagenome approach providing insights into their complete genomes. Our results highlight the importance of surveillance at the point of entries, strengthening lab capacities including next‐generation sequencing, and using differential diagnosis for timely and accurate detection of mpox cases.

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Section: Discussionmentioning

confidence: 99%

Genomic characterization of the first mpox and varicella‐zoster co‐infection in Pakistan (2023) through next‐generation sequencing

Umair,

Jamal,

Haider

et al. 2023

Journal of Medical Virology

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“…It was furtherly shown that higher ALT levels were measured among patients that received tecovirimat (and antibiotics that others that did not 104 . On the other hand, Assiri et al 105 . showed normal liver enzymes in their seven travel‐related mpox cases in Saudi Arabia, suggesting no hepatic affection.…”

Section: Hepato‐splenic Affectionmentioning

confidence: 96%

Mpox impact on different organ systems: Complications, mechanisms, and management

Reda

Dhama

2023

Reviews in Medical Virology

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Mpox (previously known as monkeypox) continues to raise concerns since many cases are still being recorded globally. Various reports have shown changing epidemiology of the disease, together with different atypical clinical characteristics of affected patients. The condition has reportedly been self-limited since most patients do not usually require hospitalisation. However, recent reports showed that some patients might suffer from related complications and require hospitalisation.Different systems were reportedly affected, including cardiac, neurological, respiratory, and renal events. In the present literature review, we aim to review these complications, discuss their potential mechanisms, and provide insight into the currently recommended diagnostic and management practices.

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“…Mpox, which had previously only been seen in Central and West Africa, has recently spread geographically to non-endemic countries, including Saudi Arabia and its neighboring nations [1 , 2] . Since January 1, 2022 to November 30, 2023, 92,783 laboratory-confirmed cases of mpox, including 171 deaths, were reported to the World Health Organization (WHO) from 116 countries/territories/areas in the six WHO regions [3] .…”

Section: Introductionmentioning

confidence: 99%

“…The clinical characteristics and epidemiology of mpox in Africa, where the majority of cases have been reported, have been the subject of several research. However, there are limited data on mpox in Saudi Arabia and its neighboring countries [1 , 2 , 4] . Thus, we conducted this study to fill this knowledge gap.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology, clinical presentation, and outcome of mpox: A study of 381 cases in Saudi Arabia

Assiri,

Alserehi,

Abuhasan

et al. 2024

IJID Regions

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Clinical features and outcome of human Mpox (Monkeypox) in Saudi Arabia: An observational study of travel-related cases

Cited by 13 publications

References 33 publications

Genomic characterization of the first mpox and varicella‐zoster co‐infection in Pakistan (2023) through next‐generation sequencing

Genomic characterization of the first mpox and varicella‐zoster co‐infection in Pakistan (2023) through next‐generation sequencing

Mpox impact on different organ systems: Complications, mechanisms, and management

Epidemiology, clinical presentation, and outcome of mpox: A study of 381 cases in Saudi Arabia

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