Clinical Features and Outcome of Solid Pseudopapillary Neoplasm

Lee, Seung Eun

doi:10.1001/archsurg.143.12.1218

Cited by 140 publications

(127 citation statements)

References 23 publications

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“…According to other reports, SPC diagnosis is a sensitive but not specific risk factor for clinically aggressive disease [18,19,43,66,67]. The percentage of SPC in the present study was 82.4%, and it was high in comparison to previous reports.…”

Section: Discussioncontrasting

confidence: 73%

Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

Liszka

Mrowiec²,

Pająk³

et al. 2014

pjp

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Solid-pseudopapillary neoplasms (SPN) are rare tumours of the pancreas. Distant metastases and/or local recurrence following surgical resection occur in 10% to 15% of patients with SPN. In the present study, we aimed to systematically examine the usefulness of virtually all histopathological features of SPN which were previously considered potential risk factors of clinically aggressive behaviour of SPN following surgical resection. Seventeen SPN were included. None of the cases had an undifferentiated component. Follow-up data were available for 14 patients (median 52 months). One patient developed liver metastasis 17 months after resection of the primary tumour and fulfilled the criteria of a clinically aggressive disease. None of the histopathological features allowed identification of that case with an adequate diagnostic yield. At present, histopathological examination cannot identify patients who may develop tumour recurrence following resection of the primary lesion. A close follow-up should be offered to all patients treated for SPN.

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Section: Discussioncontrasting

confidence: 73%

Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

Liszka

Mrowiec²,

Pająk³

et al. 2014

pjp

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“…This trend can be seen in our study, for example, 27 of 34 (79.4%) patients were diagnosed after the year 2000. Large single-institutional reports of SPN diagnoses after 2005 are summarized in table 4 [7,8,9,13,20,21,22,23,24,25,26,27,28,29,30,31,32]. …”

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas at a Single Institution

Suzuki¹,

Hatori²,

Furukawa

et al. 2014

Dig Surg

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Aims: The aim of this study was to determine the clinicopathological features and surgical management of solid pseudopapillary neoplasms (SPNs) of the pancreas at a single institution. Methods: We investigated 34 patients (5 males and 29 females) who underwent surgery for pathologically confirmed SPNs between 1994 and 2012. Results: Clinical symptoms were absent in 58.8% of the patients. The median tumor diameter was 42.7 mm. All tumors were successfully removed by R0 resection. Pathologically, 5.9% had duodenum invasion and 2.9% had pancreatic serosal invasion, but there was no lymph node metastasis. Radiological findings showed calcification in 39.4% of the patients, capsule formation in 51.5%, cystic components in 69.7%, solid components in 93.9% and internal bleeding in 36.4%. Immunohistochemically, neuron-specific enolase was positive in 100% of the patients, nuclear accumulation of β-catenin in 100% and CD10 in 78.8%. There were no recurrences reported at the median follow-up (67 months). Regarding gender differences, the cystic component in radiological imaging was the only significant finding among the features studied (p = 0.01). Conclusions: R0 resection with appropriate procedures appears to be sufficient for patients with SPNs, even for locally invasive tumors. There were no significant differences between genders except for the cystic component on radiological imaging.

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“…La excisión quirúrgica es el tratamiento curativo en muchos casos, con un pronóstico bueno después de la resección 10 . Lee encontró una frecuencia del 66.7% de tumor seudopapilar localizado en la cabeza del páncreas 11 . El término tumor sólido-seudopapilar del páncreas fue recientemente introducido.…”

Section: Discussionunclassified

Hematoma crónico de páncreas. Diagnóstico diferencial con tumos maligno. Informe de un caso

et al. 2014

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Este artículo debe citarse como: Rafael-Alemán B, Terriquez-Rodríguez S, Páez-Aguirre SF y col. Hematoma crónico de páncreas. Diagnóstico diferencial con tumor maligno. Informe de un caso. Acta Pediatr Mex 2010;31(2):64-66.www.nietoeditores.com.mx RESUMEN Introducción. Los hematomas crónicos del páncreas en niños son raros y de difícil diagnóstico. Los diagnósticos diferenciales más relevantes son: seudoquiste de páncreas cuando existe el antecedente de traumatismo, y tumor seudopapilar de páncreas cuando dicho antecedente no existe. El estudio de imagen ideal es la tomografía de abdomen. En el caso que presentamos el diagnóstico definitivo fue quirúrgico mediante biopsia transoperatoria. Informe del caso. Se presenta el caso de una adolescente de 14 años de edad con antecedente de traumatismo abdominal cerrado cuatro meses antes del inicio de su padecimiento actual, caracterizado por: dolor en abdomen superior, náuseas, vómito y pérdida de peso de 8 Kg. La tomografía reveló lesión quística en cabeza de páncreas. Con sospecha de seudoquiste de páncreas vs tumor seudopapilar se sometió a laparotomía exploradora. Durante la cirugía se descubrió hematoma capsulado de la cabeza de páncreas realizándose vaciamiento y ventana a peritoneo, así como toma de biopsia. La evolución postoperatoria fue adecuada. Discusión. El hematoma de páncreas es raro y de difícil diagnóstico. Los diagnósticos diferenciales más importantes son seudoquiste y tumor seudopapilar de páncreas. Palabras clave: Hematoma pancreático, tumor seudopapilar del páncreas, biopsia transoperatoria, traumatismo. ABSTRACTIntroduction: Chronic hematomas of the pancreas are rare and difficult to diagnose in children. The most relevant differential diagnosis include: pancreatic pseudocyst (when a history of trauma is referred) and pseudopapillary tumor of the pancreas (when a history of trauma is denied). The gold standard study imaging consists of an abdominal CT scan. In the case we present, the diagnosis was not made by CT, and could only be obtained after surgical biopsy. Case report. A case of a female adolescent with history of closed abdominal trauma 4 months before the onset of symptoms such as upper abdominal pain, nausea, vomiting, and weight loss of 8 kg. The CT image only revealed a cyst of the head of the pancreas. The differential diagnosis included: pancreatic pseudocyst vs. a malignant tumor. Surgery was indicated. During surgery, a pancreatic hematoma of the head of the pancreas was diagnosed, drained and marsupialized. The postoperative outcome was uneventful. Discussion. Hematomas of the pancreas are rare and difficult to diagnose. The most relevant differential diagnosis include: pancreatic pseudocyst and pseudopapillary tumor of the pancreas.

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Clinical Features and Outcome of Solid Pseudopapillary Neoplasm

Cited by 140 publications

References 23 publications

Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

Limited usefulness of histopathological features in identification of a clinically aggressive solid-pseudopapillary neoplasm of the pancreas

Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas at a Single Institution

Hematoma crónico de páncreas. Diagnóstico diferencial con tumos maligno. Informe de un caso

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