Clinical features and outcome in paediatric newly diagnosed immune thrombocytopenic purpura in a tertiary care centre

Zafar, Huma; Anwar, Saadia; Faizan, Mahwish; Riaz, Shazia

doi:10.12669/pjms.345.15687

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Sample inspection further ensured lack of B-line affection. Instances of this can be found in the literature [68,69].…”

Section: Appendix A2 Flow Cytometrymentioning

confidence: 99%

Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach

Chulián,

Martínez-Rubio,

Marciniak-Czochra

et al. 2020

Preprint

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Haematopoiesis is the process of generation of blood cells. Lymphopoiesis generates lymphocytes, the cells in charge of the adaptive immune response. Disruptions of this process are associated with diseases like leukaemia, which is especially incident in children. The characteristics of self-regulation of this process make them suitable for a mathematical study.In this paper we develop mathematical models of lymphopoiesis using currently available data. We do this by drawing inspiration from existing structured models of cell lineage development and integrating them with paediatric bone marrow data, with special focus on regulatory mechanisms. A formal analysis of the models is carried out, giving steady states and their stability conditions. We use this analysis to obtain biologically relevant regions of the parameter space and to understand the dynamical behaviour of B-cell renovation. Finally, we

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“…Sample inspection further ensured lack of B-line affection. Instances of this can be found in the literature [68,69].…”

Section: Appendix A2 Flow Cytometrymentioning

confidence: 99%

Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach

Chulián,

Martínez-Rubio,

Marciniak-Czochra

et al. 2020

Preprint

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Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach

Chulián

Martínez-Rubio

Marciniak–Czochra

et al. 2021

Journal of Theoretical Biology

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<i>Helicobacter pylori</i> infection in children with immune thrombocytopenia

Ragab,

El-Hawy,

Awad

et al. 2023

Voprosy gematologii/onkologii i immunopatologii v pediatrii

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To detect the association between Helicobacter pylori (H. pylori) infection and immune thrombocytopenia in children and adolescents. Immune thrombocytopenia (ITP) is a common bleeding disorder in childhood. H. pylori is a widespread organism that is present in about 50% of the global population. There is an obvious relation between helicobacter pylori infection and chronic idiopathic thrombocytopenic purpura. A cross-sectional study was conducted in 95 patients with ITP who were recruited from the Hematology Unit, Department of Pediatrics, Menoufia University Hospital in the period from June 2021 to June 2022. The age of the patients ranged between 3.5 and 7.5 years. Fifty-five of them were males and 40 were females. The study was approved by the Ethical Committee of the Faculty of Medicine, Menoufia University. Out of the studied ITP children, 62 (65.3%) were positive for H. pylori antigen in stool, and 33 (34.7%) were negative. There was a significant difference between H. pylori-positive and H. pylori-negative patients regarding the grade of bleeding at presentation; 51 (82.3%) H. pylori-positive patients presented with grade 3 bleeding, 35 (56.5%) of them presented with skin and gum bleeding, 16 (25.8%) presented with skin bleeding and epistaxis. There was a statistically significant difference in the rate of recovery between H. pylorinegative patients (78.8%) and H. pylori-positive patients (22.6%). There was a significant rise in the platelet count in H. pylori-positive patients after the treatment of H. pylori. The prevalence of H. pylori infection in ITP pediatric patients was 65.3%. There was a significant rise in the platelet count in H. pylori-positive ITP children after the treatment of H. pylori.

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Clinical features and outcome in paediatric newly diagnosed immune thrombocytopenic purpura in a tertiary care centre

Cited by 4 publications

References 12 publications

Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach

Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach

Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach

<i>Helicobacter pylori</i> infection in children with immune thrombocytopenia

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