Clinical features and lymphocytes metabolic parameters of children 7-11 years with gallbladder dysfunction and with its association with giardiasis

Abstract

Purpose. Investigation of the clinical features and metabolic status of blood lymphocytes in children aged 7-11 years with gallbladder dysfunction depending on the presence or absence of giardiasis.
 Materials and methods. Children aged 7–11 years with gallbladder dysfunction (GD) were examined in depending on the presence or absence of giardiasis. Enzyme activity in blood lymphocytes was determined by bioluminescent method.
 Results. There are diarrheal disorders are more common in clinic dysfunction of gallbladder and flatulence – for gallbladder dysfunction in association with giardiasis. Enlargement of the liver and cystic positive symptoms are also characterized by dysfunction of gallbladder on a background of giardiasis. Significant changes in the NAD(P)-dependent dehydrogenases lymphocytes activity found in children with gallbladder dysfunction: reduced levels of substrate flux at the terminal glycolysis reactions and the tricarboxylic acid cycle, which determines the inhibition, respectively, anaerobic and aerobic respiration of cells.
 Conclusion. Found that children with combined pathology had in lymphocytes, while maintaining the intensity of the terminal reactions of anaerobic glycolysis at the reference level reduced enzyme activity, determining the state of aerobic respiration. Independently from the presence or absence of giardiasis in children with gallbladder dysfunction reduced activity of the pentose phosphate cycle that characterizes the inhibition of the corresponding reactions of macromolecular synthesis.