Clinical features and immune mechanisms directly linked to the altered liver function in patients with rheumatoid arthritis

Rosa, I. Arias de la; Ruiz-Ponce, M.; Cuesta-López, Laura; Pérez-Sánchez, C.; Leiva-Cepas, Fernando; Gahete, Manuel D.; Navarro, Pilar; Ortega‐Castro, Rafaela; Córdoba-Chacón, José; Pérez‐Pampín, Eva; González, Antonio G.; Lucendo, Alfredo J.; Estévez, E. Collantes; López-Pedrera, C.; Contreras, A. Escudero; Barbarroja, Nuria

doi:10.1016/j.ejim.2023.08.002

Cited by 4 publications

(1 citation statement)

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“…Of note, ACPAs may incite vascular inflammation and coronary artery calcification by the yet-unknown mechanisms, which may at least in part explain the increased cardiovascular events in RA patients compared to healthy individuals [ 74 – 76 ]. ACPAs induced a defective hepatocyte function, promoting inflammation, apoptotic, and fibrotic processes [ 77 ]. Improved understanding of the correlation between different metabolites and disease severity may lend novel insights and facilitate the identification of new biomarkers and therapeutic targets for RA.…”

Section: Pathogenic Effects Of Acpasmentioning

confidence: 99%

The role of anti-citrullinated protein antibody in pathogenesis of RA

Ma,

Liang,

et al. 2024

Clin Exp Med

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Rheumatoid arthritis (RA) is a common autoimmune rheumatic disease that causes chronic synovitis, bone erosion, and joint destruction. The autoantigens in RA include a wide array of posttranslational modified proteins, such as citrullinated proteins catalyzed by peptidyl arginine deiminase4a. Pathogenic anti-citrullinated protein antibodies (ACPAs) directed against a variety of citrullinated epitopes are abundant both in plasma and synovial fluid of RA patients. ACPAs play an important role in the onset and progression of RA. Intensive and extensive studies are being conducted to unveil the mechanisms of RA pathogenesis and evaluate the efficacy of some investigative drugs. In this review, we focus on the formation and pathogenic function of ACPAs.

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Section: Pathogenic Effects Of Acpasmentioning

confidence: 99%