Clinical features and drug-resistance in pediatric epilepsy with co-occurring autism: A retrospective comparative cohort study

Lob, Karen; Hou, Tao; Chu, Tzu-Chun; Ibrahim, Nouran; Bartolini, Luca; Nie, Duyu

doi:10.1016/j.yebeh.2023.109228

Cited by 6 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings, similar to findings from children without DS who have other ND and MH conditions, show higher rates of ophthalmologic problems, GI problems, musculoskeletal problems, and epilepsy (Bellato et al, 2023;Fulceri et al, 2016;Galéra et al, 2022;Grönlund et al, 2007;Lob et al, 2023;Restrepo et al, 2020;Williams & Burnfield, 2019). However, the basis of this association is unknown, and may represent a complex multidirectional relationship in which the ND, MH, and medical conditions exacerbate one another; a shared etiology; or increased medical attention and surveillance of medical conditions in individuals with ND disorders resulting in higher rates of diagnosis (Bolton, 2009).…”

Section: Relationships Between Medical and Nd And Mh Conditionssupporting

confidence: 89%

Co‐occurring conditions in Down syndrome: Findings from a clinical database

Baumer,

Hojlo,

Pawlowski

et al. 2023

American J of Med Genetics Pt C

View full text Add to dashboard Cite

Individuals with Down syndrome (DS) experience a range of medical and neurodevelopmental conditions, necessitating systematic study of their occurrence and impact on neurodevelopmental outcomes. We describe the prevalence and relationships of medical, neurodevelopmental (ND), and mental health (MH) conditions in children with DS. We created a prospective clinical database of individuals with DS, integrated into the workflow of a specialty Down Syndrome Program at a specialty pediatric referral hospital. Conditions were collected through caregiver‐ and clinician report at clinical visits (N = 599). We calculated frequencies of medical, ND, and MH conditions and then assessed the relationship between medical, ND, and MH conditions using frequencies and comparative statistics. The most frequent co‐occurring conditions were vision (72.5%), ear/hearing (71.0%), gastrointestinal (61.3%), respiratory (45.6%), and feeding (33.6%) problems, with variation in frequency by age. ND and MH conditions were reported in one quarter, most commonly autism spectrum disorder and attention‐deficit/hyperactivity disorder. Those with ND and MH conditions had greater frequency of medical conditions, with highest rates of vision, ear/hearing, and gastrointestinal issues, and CHD. Systematically collected clinical data in a large cohort of children with DS reveals high prevalence of several co‐occurring medical, ND, and MH conditions. Clinical care requires an understanding of the complex relationship between medical conditions and neurodevelopment.

show abstract

Section: Relationships Between Medical and Nd And Mh Conditionssupporting

confidence: 89%

Co‐occurring conditions in Down syndrome: Findings from a clinical database

Baumer,

Hojlo,

Pawlowski

et al. 2023

American J of Med Genetics Pt C

View full text Add to dashboard Cite

show abstract

“…The limited studies on epilepsy and ASD suggest that this population is distinct from that of patients with epilepsy alone. For example, when examining patients with ASD and epilepsy, generalized motor seizures are more common, and MRI abnormalities are less common than in patients with epilepsy alone [94]. Since the clinical features, laboratory investigations, and treatment responses may differ in patients with ASD, epilepsy, and aggression as compared to those without all three co-morbidities, future research needs to focus on the unique clinical aspects of this subpopulation.…”

Section: Discussionmentioning

confidence: 99%

Developmental Regression Followed by Epilepsy and Aggression: A New Syndrome in Autism Spectrum Disorder?

Gaitanis

Nie

Hou

et al. 2023

JPM

Self Cite

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) with regression (ASD-R) involves the loss of previously attained developmental milestones, typically during the first or second year of life. As children age, it is not uncommon for them to develop comorbid conditions such as aggressive behaviors or epilepsy, which can inhibit habilitation in language and social function. In this paper, we hypothesize that aggressive behaviors and epilepsy more commonly develop in patients with ASD-R than in those without a history of regression (ASD-NR). We conducted a retrospective review of non-syndromic patients with ASD over 12 years of age and compared the rates of epilepsy and aggression between ASD-R and ASD-NR patients. Patients with ASD-R, as compared to ASD-NR patients, demonstrated non-significantly higher rates of epilepsy (51.8% vs. 38.1%, p = 0.1335) and aggressive behaviors (73.2% vs. 57.1%, p = 0.0673) when evaluated separately. The rates for combined epilepsy and aggression, however, were statistically significant when comparing ASD-R versus ASD patients (44.5% vs. 23.8%, p = 0.0163). These results suggest that epilepsy with aggression is more common in ASD-R as compared to ASD-NR patients. When considering the impact of epilepsy and aggression on quality of life, these co-morbidities effectively cause a second regression in patients who experienced an earlier regression as toddlers. A larger, prospective trial is recommended to confirm these associations and further define the timeline in which these characteristics develop from early childhood to adolescence.

show abstract