Clinical features and disease outcomes of undifferentiated arthritis in Thailand

Foocharoen, Chingching; Nanagara, Ratanavadee; Suwannaroj, Siraphop; Mahakkanukrauh, Ajanee

doi:10.1111/j.1756-185x.2011.01606.x

Cited by 6 publications

(5 citation statements)

References 35 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Biologic treatment has less side effects with good outcome (Zavvar et al, 2019) but as most of the patients from the developing centuries have no affordability for the treatment and its need for regular follow up, HCQ provides a better option. Regarding male to female ratio there are only few studies that estimated the sex difference in EUA, they also carry similar findings of this study as all of them showed that female constituted more than two thirds of total EUA patients (O16 Aetiology of early undifferentiated arthritis in India, 2009;Shankar S, 2010), no clear explanation have been identified yet but as EUA is an immunological disease (Foocharoen, Nanagara, Suwannaroj, & Mahakkanukrauh, 2011), recent evidence suggest that female hormones such as estrogen have strong role in development of autoimmune diseases (Somers & Richardson, 2014).…”

Section: Treatment Responcesupporting

confidence: 84%

The Role of Hydroxychloroquine as Monotherapy in Managing Early Undifferentiated Arthritis: A Prospective Hospital-Based Study

Mahmoud

Hussein

Essa³

et al. 2019

GJPHM

View full text Add to dashboard Cite

Introduction: Early undifferentiated arthritis (EUA) is a common form of arthritis comprising, joint pain, stiffness and swelling with no definitive diagnosis. Patients of EUA can progress to other forms of rheumatic arthropathies such as rheumatoid arthritis or remain in the same form or spontaneously disappear. The main focus of this study is to explore the potential effect of hydroxychloroquine (HCQ) in management of EUA as a monotherapy treatment. Methods: This is a prospective hospital-based study which was conducted in Almwada hospital in Khartoum, Sudan. The study included thirty patients of EUA. Full clinical examination and history were done by a rheumatologist, and all the related investigations were obtained, and they all received HCQ after EUA diagnosis has been established. Result: The study shows that 96% of the patients responded well to the treatment and 10% had their duration of treatment doubled to show a favorable response. We also found that female patients weremore commonly affected than male ones with higher incidence among middle aged as compared to others. After treatment with HCQ, 86.6% of the patients showed average mean decrease in erythrocyte sedimentation rate (ESR) by 44%, the other 13.4%, even though they were symptoms free after treatment they showed increased level of ESR by 30% average. Conclusion: In the present study we found out most of the EUA patients are well responded to the HCQ treatment, and most of them respond from the first course of treatment, the study also shows higher incidence among female in compared to male.

show abstract

Section: Treatment Responcesupporting

confidence: 84%

The Role of Hydroxychloroquine as Monotherapy in Managing Early Undifferentiated Arthritis: A Prospective Hospital-Based Study

Mahmoud

Hussein

Essa³

et al. 2019

GJPHM

View full text Add to dashboard Cite

show abstract

“…The data from the literature show that 50 U l 21 in pericardial fluid is a reliable threshold for TB diagnosis (El Jahiri et al, 2006). Synovial fluid ADA levels higher than 31 U l 21 were highly correlated with a diagnosis of TB arthritis, with a high sensitivity and specificity (Foocharoen et al, 2011).…”

Section: Discussionmentioning

confidence: 94%

Use of adenosine deaminase measurements and QuantiFERON in the rapid diagnosis of tuberculous peritonitis

Saleh¹,

Hammad

Ramadan

et al. 2012

Journal of Medical Microbiology

View full text Add to dashboard Cite

Peritoneal tuberculosis (TB) is a considerable problem in certain developing nations. Current diagnostic tests for peritoneal TB are difficult and time-consuming. This study aimed to determine the effectiveness of an adenosine deaminase (ADA) assay and the QuantiFERON-Gold (QFT-G) assay in the rapid diagnosis of TB peritonitis. Forty-one patients with a presumptive diagnosis of TB peritonitis with ascites were admitted to Mansoura University Hospital and included in the study. Ascitic fluid and blood samples were collected from each patient. Fluid samples were examined biochemically (protein concentration), cytologically (white blood cell count) and microbiologically (Ziehl-Neelsen stain and TB culture in Lö wenstein-Jensen media), and ADA levels were determined using colorimetry. Interferon-c levels in whole-blood samples were measured using the QFT-G assay. Fourteen (34 %) patients received a final clinical diagnosis of TB peritonitis; these patients were subclassified as definite (positive culture for Mycobacterium tuberculosis; eight patients), highly probable (four patients) and probable (two patients) for TB peritonitis. Of the 14 patients with a final clinical diagnosis of TB peritonitis, 3 (21 %) tested positive using an acid-fast bacilli smear, which showed a sensitivity of 21 % and a specificity of 100 %. A receiver operating characteristic curve showed that a cut-off value of 35 IU l "1 for the ADA level produced the best results as a diagnostic test for TB peritonitis, yielding the following parameter values: sensitivity 100 %, specificity 92.6 %, positive predictive value (PPV) 87.5 % and negative predictive value (NPV) 100 %. The QFT-G assay yielded the following values: sensitivity 92.9 %, specificity 100 %, PPV 100 % and NPV 96.4 %. The ADA and QFT-G assays might be used to rapidly diagnose TB peritonitis and initiate prompt treatment while waiting for a final diagnosis using the standard culture approach.

show abstract

“…Igualmente, se obtuvo un bajo porcentaje de remisión espontánea un año después de realizado el diagnóstico; hallazgo que contrasta con lo publicado en otras series (29)(30)(31)(32)(33)(34), lo cual podría explicarse por el manejo farmacológico precoz y el seguimiento estricto de los individuos de esta cohorte.…”

Section: Discussionunclassified

Characterization of patients with undifferentiated arthritis and evolution to other inflammatory diseases in a Colombian northwestern cohort: An observational study

Tobón

Zapata

Gómez

et al. 2021

sun

View full text Add to dashboard Cite

show abstract

Clinical features and disease outcomes of undifferentiated arthritis in Thailand

Abstract: The most common presentation of Thai UA was asymmetrical oligoarthritis and most patients had persistent arthritis correlated with hyperglobulinemia. Elderly-onset, without any radiographic changes or rheumatoid factor, was predictive of RA development during follow-up.

Cited by 6 publications

References 35 publications

The Role of Hydroxychloroquine as Monotherapy in Managing Early Undifferentiated Arthritis: A Prospective Hospital-Based Study

The Role of Hydroxychloroquine as Monotherapy in Managing Early Undifferentiated Arthritis: A Prospective Hospital-Based Study

Use of adenosine deaminase measurements and QuantiFERON in the rapid diagnosis of tuberculous peritonitis

Characterization of patients with undifferentiated arthritis and evolution to other inflammatory diseases in a Colombian northwestern cohort: An observational study

Contact Info

Product

Resources

About