Clinical Features and Differential Diagnoses in Laryngeal Mucoepidermoid Carcinoma

Mokhtari, Sepideh; Mokhtari, Saeedeh

doi:10.4137/cpath.s8435

Cited by 17 publications

(16 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most studies agree that the prognosis of malignant minor salivary gland carcinomas of the larynx is determined by the histological tumour type, the differentiation grade and the ability to achieve complete surgical resection [12]. Survival rate analysis in our group of patients showed 3- and 5-year overall survival rates of 46.7 and 20%, respectively, which are lower than in some reports [6].…”

Section: Discussioncontrasting

confidence: 49%

Malignant Minor Salivary Gland Carcinomas of the Larynx

Zhang¹,

Li²,

Li³

et al. 2014

ORL

View full text Add to dashboard Cite

Aims: To explore the clinical characteristics and treatment of malignant minor salivary gland carcinomas of the larynx. Methods: Clinical patient information regarding presentation, pathology, treatment and outcome was obtained through a review of patient charts. Results: Malignant minor salivary carcinomas in the larynx were confirmed pathologically in 15 patients (11 males, 4 females) between 2003 and 2010 in our hospital; 6 patients had mucoepidermoid carcinoma (MEC; 40%), 6 had adenoid cystic carcinoma (ACC; 40%) and 3 had adenocarcinoma (20%). The most common tumour location was the subglottis (60%), followed by the supraglottis (33%). In total, 13 patients underwent surgery, of which 10 (77%) had positive/insufficient resection margins. The mean follow-up time was 42.3 months, with a range of 8-129 months. The 3- and 5-year overall survival rates were 46.7 and 20%, respectively. Conclusion: Malignant minor salivary gland carcinoma of the larynx is a rare disease that showed male predominance in our study. The carcinomas were most often localised in the subglottic region, and the most common histological types were ACC and MEC. Wide-margin surgery with postoperative radiotherapy is advocated. The overall prognosis is poor compared to squamous cell carcinomas of the same location and tumour stage.

show abstract

Section: Discussioncontrasting

confidence: 49%

Malignant Minor Salivary Gland Carcinomas of the Larynx

Zhang¹,

Li²,

Li³

et al. 2014

ORL

View full text Add to dashboard Cite

show abstract

“…The diagnosis of high‐grade MEC is challenging and its morphology can mimick other high‐grade tumors such as SCC, adenosquamous carcinoma, and salivary duct carcinoma. High‐grade MEC and SCC have similar histopathological features, and the presence of intermediate and mucous cells is the main key for the differentiation of these tumors (3, 43). The adenosquamous carcinoma is a rare variant of the SCC with a different clinical presentation when compared with the MEC (43, 44).…”

Section: Discussionmentioning

confidence: 99%

“…High‐grade MEC and SCC have similar histopathological features, and the presence of intermediate and mucous cells is the main key for the differentiation of these tumors (3, 43). The adenosquamous carcinoma is a rare variant of the SCC with a different clinical presentation when compared with the MEC (43, 44). Microscopically presents typical areas of SCC with keratin pearl formation, anaplasia, intercellular junctions, SCC in situ component in the overlying mucosa, presence of mucous cells and mucin stain, and absence of intermediate cells (43, 44).…”

Section: Discussionmentioning

confidence: 99%

“…The adenosquamous carcinoma is a rare variant of the SCC with a different clinical presentation when compared with the MEC (43, 44). Microscopically presents typical areas of SCC with keratin pearl formation, anaplasia, intercellular junctions, SCC in situ component in the overlying mucosa, presence of mucous cells and mucin stain, and absence of intermediate cells (43, 44). The acantolytic carcinoma is an extremely rare variant of SCC in the oral region and histopathologically presents typical areas of SCC including keratin pearl formation, with acantholytic or dysketaratotic cells resulting in pseudovascular or pseudoglandular spaces; it shows involvement of the overlying epithelium and absence of mucous and intermediate cells and mucin production (45, 46).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Expression pattern of PLUNC proteins as an auxiliary tool for the diagnosis of high‐grade mucoepidermoid carcinoma of the salivary gland

González‐Arriagada

Santos‐Silva

Ito

et al. 2012

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…However, mucoepidermoid carcinoma is much more rarely seen in the larynx. 1 Mucoepidermoid carcinomas are made up of three cell types. The cell types include: epidermoid cells, mucus secreting cells, and intermediate cells.…”

Section: Introductionmentioning

confidence: 99%

Recurrent High-Grade Invasive Mucoepidermoid Carcinoma of Larynx: A Case Report and Review of the Literature

King

Miller

2016

Rare Tumors

View full text Add to dashboard Cite

Recurrent invasive high-grade mucoepidermoid carcinoma of the larynx and hypopharynx is a rare occurrence. These tumors have been commonly associated with salivary gland tumors, most commonly the parotid gland. The patient usually presents with the following symptoms: hoarseness (if larynx is involved), or changes in voice character, sore throat, cough, odynophagia, dysphagia, otalgia, difficulty breathing, weight loss, lymphadenopathy. Here we present a case of a recurrent invasive high-grade mucoepidermoid carcinoma of larynx and hypopharynx. The patient was a 67-year-old male that originally presented in 2006. At that time he underwent a wide field laryngectomy, right thyroid lobectomy, and biopsy of the right digastric node. He was a clinical stage III, pT3N0M0. No adjuvant radiation therapy was given at that time. The patient remained asymptomatic until February 2014, when he presented with dysphagia and neck swelling. Positron emission tomography/computed tomography showed evidence of recurrence. The patient was treated with definitive intensity modulated radiation therapy (IMRT) with concurrent chemotherapy. Treatment for this disease is gathered by scattered case reports. If surgery is a possibility it is considered as first line therapy. Post-surgical radiation is then offered. However, in this case the recurrent tumor was located near the carotid artery, and thus surgery was not a possibility. Therefore, concurrent chemotherapy and radiation with IMRT and weekly cis-platinum was given. While the optimum combination of treatment has not yet been established because of the rarity of this cancer’s location site, the current patient appeared to have an excellent response from the definitive IMRT and chemotherapy treatment.

show abstract

Clinical Features and Differential Diagnoses in Laryngeal Mucoepidermoid Carcinoma

Cited by 17 publications

References 33 publications

Malignant Minor Salivary Gland Carcinomas of the Larynx

Malignant Minor Salivary Gland Carcinomas of the Larynx

Expression pattern of PLUNC proteins as an auxiliary tool for the diagnosis of high‐grade mucoepidermoid carcinoma of the salivary gland

Recurrent High-Grade Invasive Mucoepidermoid Carcinoma of Larynx: A Case Report and Review of the Literature

Contact Info

Product

Resources

About