Clinical features and diagnosis of Hodgkin's disease

Ultmann, John E.

doi:10.1002/1097-0142(196603)19:3<297::aid-cncr2820190302>3.0.co;2-p

Cited by 39 publications

(10 citation statements)

References 81 publications

(3 reference statements)

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“…The spleen is involved initially in up to 30% of Hodgkin cases [2]. Small areas Although in our patient the syndrome of fever, splenomegaly, and a cystic defect Hodgkin disease should be included in the differential diagnosis of cystic lesions…”

Section: Acknowledgmentsmentioning

confidence: 65%

Acute hodgkin disease masquerading as splenic abscess

Bloom

Freund

Perkes

et al. 1981

Journal of Surgical Oncology

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A splenic abscess was erroneously diagnosed in a 65-year-old patient. The diagnosis was established on clinical, radiological and ultrasonographic data. At laparotomy the spleen was markedly enlarged by tumoral tissue and contained a large cystic lesion. The histological diagnosis was typical Hodgkin disease with lymphocytic depletion. Ultrasonography adds valuable information in the diagnosis of splenic lesions. Hodgkin disease should be included in the differential diagnosis of cystic lesions detected in the spleen by this method.

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Section: Acknowledgmentsmentioning

confidence: 65%

Acute hodgkin disease masquerading as splenic abscess

Bloom

Freund

Perkes

et al. 1981

Journal of Surgical Oncology

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“…Five of our patients showed a hypochromic microcytic anaemia. Ultmann et al (1966) found such anaemia in 10% of patients with HD at presentation. None of our patients haad iron deficiency as judged from stainable iron in the marrow or the level of serum ferritin.…”

Section: Discussionmentioning

confidence: 81%

Erythropoiesis and iron metabolism in Hodgkin's disease

Al‐Ismail¹,

Cavill²,

Evans³

et al. 1979

Br J Cancer

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Summary.-Recently developed techniques for the investigation of iron kinetics were used to study the disturbance of iron metabolism in 19 untreated patients with Hodgkin's diseases (HD). The erythroid abnormality in newly diagnosed HD appears to be confined to those patients with systemic symptoms of weight loss, night sweats and fever, and consists of depression of marrow erythroid activity. These patients had a significantly lower haemoglobin and serum iron concentration and a higher serum ferritin concentration, both when compared to normal subjects and to those patients with HD who lacked systemic symptoms. Ineffective erythropoiesis and redcell destruction were not significantly increased. The present findings confirm that HD patients with systemic symptoms have a depression of erythropoiesis, and that in these patients the marrow fails to respond to the stimulus of mild anaemia.

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“…Spectrophotometric assays of xanthine oxidase activity were confirmed using radioactive tracer techniques. 10 In certain experiments, in order to measure the distribution of enzyme activity in the soluble and insoluble phases after antibody precipitation, the enzyme-antibody precipitate was removed by centrifugation at 0" C. and resuspended in a volume of glycylglycine buffer equal to that of the original suspension. Xanthine oxidase activity was then assayed independently in the supernatant and the precipitate suspension.…”

Section: Neotetrazoliummentioning

confidence: 99%

The Interaction Between Xanthine Oxidase and Its Antibody*

Ultmann

Feigelson

1963

Annals of the New York Academy of Sciences

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Immunochemical techniques have been applied in many laboratories to investigations of molecular heterogeneity of mammalian enzymes, such as alkaline phosphatases, amylases, lactic dehydrogenases, phosphorylases, and glucose-6-phosphate dehydrogenases. Enzyme-antibody studies may provide information about the enzyme-antibody interaction and specificity, the composition and the structure of enzymes, and the nature of the enzyme-substrate relationship at the active catalytic site.2The present experiments were undertaken to determine the relationship of the antibody binding sites to the active center of the enzyme; to determine the effect of substrate and a competitive inhibitor on the antigenantibody interaction; and to investigate tissue and species enzyme protein immunologic specificity in mature organisms. 4 Materials and MethodsPreparation of xanthine oxidases from various sources. Bovine cream xanthine oxidase (Cr.X.0. ) ( Worthington Biochemical Corporation) was purified by ammonium sulfate fractionation followed by chromatography on hydroxylapatite columns. Purified xanthine oxidase preparations were obtained by similar techniques from homogenates of bovine liver, spleen, and kidney as well as from rat and human liver. Thermally denatured cream xanthine oxidase was prepared by maintaining the enzyme solution at 70" C. for 30 minutes.Production of antibodies. The active and the heat-inactivated Cr.X.0. antigens were injected intradermally as emulsions with complete Freund's adjuvant (Difco) at weekly intervals for four consecutive weeks. A total of 3.3 mg. enzyme protein was given to each animal. In the fifth week, these and control rabbits were bled by cardiac puncture. Purified preparations of y-globulins were isolated from the rabbit sera by the method of Heremans et al. The rabbit y-globulins were then adsorbed with beef serum.

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Clinical features and diagnosis of Hodgkin's disease

Cited by 39 publications

References 81 publications

Acute hodgkin disease masquerading as splenic abscess

Acute hodgkin disease masquerading as splenic abscess

Erythropoiesis and iron metabolism in Hodgkin's disease

The Interaction Between Xanthine Oxidase and Its Antibody*

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