“…The model constructed, which included age, male gender, cardiac syncope in the prior 6 months, prior non-sustained VT, number of PVCs in 24 h, number of leads with TWI and right ventricular ejection fraction, demonstrated an improved ability to estimate risk of ventricular arrhythmias and guide decision-making in ICD implantation for such patients (41). A meta-analysis identified the following 11 variables as the most important factor for predicting arrhythmic events: (1) male gender, (2) presyncope, (3) left ventricular dysfunction, (4) TWI in inferior leads, (5) proband status, (6) late potentials, (7) syncope, (8) inducibility at electrophysiological study, (9) right ventricular dysfunction, (10) epsilon waves, and (11) premature ventricular contractions greater than 1000/24 h (42). To our knowledge, such scoring algorithms have not been used to investigate outcomes beyond VT/VF in ARVC/D cohorts.…”