Clinical factors that impair health-related quality of life in ulcerative colitis patients vary with the disease duration

Abstract

Factors that affected the HRQOL of UC patients varied according to the patients' disease duration. Our findings should assist in the development of a long-term strategy for the treatment of UC patients.

Effects of vedolizumab on health‐related quality of life in patients with ulcerative colitis: results from the randomised GEMINI 1 trial

“…These treatment‐related benefits parallel those observed in clinical outcomes such as remission, response, and mucosal improvement. At one level, this observation is not surprising because clinical disease activity is a major determinant of HRQL in patients with ulcerative colitis; however, ulcerative colitis is a complex disease that may adversely affect patients’ social life, employment status, and psychological functioning, and these domains may not improve after a relatively short course of therapy during a lifetime disease experience. More than 80% concordance was demonstrated between patients in clinical remission and those in IBDQ‐defined remission, and Kappa statistics supported substantial agreement between the two (Table ).…”

“…Results from a large European survey indicated that approximately three‐quarters of patients with ulcerative colitis reported that symptoms interfere with their ability to enjoy leisure activities; almost 70% stated that symptoms negatively affect work performance . Although disease activity is strongly inversely correlated with HRQL as assessed by both generic and disease‐specific instruments, it does not fully account for HRQL status; some patients report poor HRQL even during periods of low disease activity . Numerous studies have suggested that perceived stress level, anxiety or depression, female sex, coexisting fatigue, and number of relapses are independent determinants of low HRQL in patients with inflammatory bowel disease; however, this area remains poorly understood.…”

Qualidade de vida de pacientes com doença de Crohn

“…Desde el punto de vista de la clínica, altos números de hospitalizaciones y complicaciones son factores determinantes en la CV. En cuanto a la presencia de fístula, datos encontrados en este estudio y en otras investigaciones, demostraron menores índices en la CV en esos pacientes (29) .…”

Does Delaying Endoscopic Sinus Surgery Adversely Impact Quality‐of‐Life Outcomes?

“…A robust body of literature exists outside otolaryngology, which has linked chronic inflammation to reduced patient-reported QOL, 19 suggesting that chronic disease duration may impact QOL. 20,21 This has led to increased interest in understanding whether earlier intervention for CRS, such as ESS, might improve long-term outcomes. Initial investigations have suggested that delayed surgical intervention for CRS may in fact adversely impact outcomes, 4 with increased risk of developing asthma, 5 irreversible upper-airway remodeling, and recalcitrant disease.…”

“…A robust body of literature exists outside otolaryngology, which has linked chronic inflammation to reduced patient‐reported QOL, suggesting that chronic disease duration may impact QOL . This has led to increased interest in understanding whether earlier intervention for CRS, such as ESS, might improve long‐term outcomes.…”