Clinical Factors That Affect the Relationship between Head Circumference and Brain Volume in Very‐Low‐Birth‐Weight Infants

Kawasaki, Yukako; Yoshida, Taketoshi; Matsui, Mié; Hiraiwa, A; Inomata, Satomi; Tamura, Kentaro; Makimoto, Masami; Oishi, Kenichi

doi:10.1111/jon.12558

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…In preterm infants however, head circumference often poorly reflects brain size due to head deformities and increased extracerebral fluid. 3,4 Brain imaging techniques can add valuable information on the actual size of the brain. MR imaging is considered the most reliable method but is not bedside-available and is expensive, limiting the possibility of serial repeat imaging.…”

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confidence: 99%

Early Ultrasonic Monitoring of Brain Growth and Later Neurodevelopmental Outcome in Very Preterm Infants

Beunders¹,

Roelants²,

Suurland

et al. 2022

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:In infants born very preterm, monitoring of early brain growth could contribute to prediction of later neurodevelopment. Therefore, our aim was to investigate associations between 2 early cranial ultrasound markers (corpus callosum-fastigium and corpus callosum length) and neurodevelopmental outcome and the added value of both markers in the prediction of neurodevelopmental outcome based on neonatal risk factors and head circumference in very preterm infants. MATERIALS AND METHODS:This prospective observational study included 225 infants born at ,30 weeks' gestational age, of whom 153 were without any brain injury on cranial ultrasound. Corpus callosum-fastigium and corpus callosum length and head circumference were measured at birth, 29 weeks' gestational age, transfer from the neonatal intensive care unit to a level II hospital, and 2 months' corrected age. We analyzed associations of brain markers and their growth with cognitive, motor, language, and behavioral outcome at 2 years' corrected age. RESULTS:In infants without brain injury, greater corpus callosum-fastigium length at 2 months was associated with better cognitive outcome. Corpus callosum length at 2 months was positively associated with cognitive, motor, and language outcome. Faster growth of the corpus callosum length between birth and 2 months was associated with better cognitive and motor function. Prediction of neurodevelopmental outcome based on neonatal risk factors with or without head circumference was significantly improved by adding corpus callosum length.

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mentioning

confidence: 99%

Early Ultrasonic Monitoring of Brain Growth and Later Neurodevelopmental Outcome in Very Preterm Infants

Beunders¹,

Roelants²,

Suurland

et al. 2022

AJNR Am J Neuroradiol

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“…Children with a head circumference more than two standard deviations (SDs) above or below the norm are recommended for further neurological evaluation and necessary treatment. New advances in radiology have provided methods to estimate brain volume with greater sensitivity and precision than what previous methods could achieve [5,6] . Studies have found that magnetic resonance imaging (MRI)-based brain volume calculation may be the better imaging-based technique to describe the development of the brain in both neonates and children [5,6] .…”

Section: Introductionmentioning

confidence: 99%

“…New advances in radiology have provided methods to estimate brain volume with greater sensitivity and precision than what previous methods could achieve. [ 5 , 6 ] Studies have found that magnetic resonance imaging (MRI)-based brain volume calculation may be the better imaging-based technique to describe the development of the brain in both neonates and children. [ 5 , 6 ] It can also provide real-time analyses of brain function.…”

Section: Introductionmentioning

confidence: 99%

Genetic background of idiopathic neurodevelopmental delay patients with significant brain deviation volume

Chen

Yan

et al. 2023

Chinese Medical Journal

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Background:Significant brain volume deviation is an essential phenotype in children with neurodevelopmental delay (NDD), but its genetic basis has not been fully characterized. This study attempted to analyze the genetic factors associated with significant whole-brain deviation volume (WBDV).Methods:We established a reference curve based on 4222 subjects ranging in age from the first postnatal day to 18 years. We recruited only NDD patients without acquired etiologies or positive genetic results. Cranial magnetic resonance imaging (MRI) and clinical exome sequencing (2742 genes) data were acquired. A genetic burden test was performed, and the results were compared between patients with and without significant WBDV. Literature review analyses and BrainSpan analysis based on the human brain developmental transcriptome were performed to detect the potential role of genetic risk factors in human brain development.Results:We recruited a total of 253 NDD patients. Among them, 26 had significantly decreased WBDV (<−2 standard deviations [SDs]), and 14 had significantly increased WBDV (>+2 SDs). NDD patients with significant WBDV had higher rates of motor development delay (49.8% [106/213] vs. 75.0% [30/40], P = 0.003) than patients without significant WBDV. Genetic burden analyses found 30 genes with an increased allele frequency of rare variants in patients with significant WBDV. Analyses of the literature further demonstrated that these genes were not randomly identified: burden genes were more related to the brain development than background genes (P = 1.656e–9). In seven human brain regions related to motor development, we observed burden genes had higher expression before 37-week gestational age than postnatal stages. Functional analyses found that burden genes were enriched in embryonic brain development, with positive regulation of synaptic growth at the neuromuscular junction, positive regulation of deoxyribonucleic acid templated transcription, and response to hormone, and these genes were shown to be expressed in neural progenitors. Based on single cell sequencing analyses, we found TUBB2B gene had elevated expression levels in neural progenitor cells, interneuron, and excitatory neuron and SOX15 had high expression in interneuron and excitatory neuron.Conclusion:Idiopathic NDD patients with significant brain volume changes detected by MRI had an increased prevalence of motor development delay, which could be explained by the genetic differences characterized herein.

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“…Cephalometry is carried out utilizing several methods, including photogrammetry, ultrasound, CT scan, MRI, and the use of standard lateral skull radiographs or cephalograms. 6,7 Determination of anthropometric measurements and reference ranges of each ethnic group is therefore essential for indicating the degree of deviations from normal. Moreover, background newborn anthropometric data, which could assess deviations from normal, are generally lacking in developing countries.…”

Section: Introductionmentioning

confidence: 99%

A descriptive study of Cephalic and prosopic anthropometric indices in one-day-old infants in Imam Ali and Kamali Hospital, Karaj

Kermanian

Tavakol

Beiranvand

et al. 2022

J. Contemp. Med. Sci.

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Objective: There is no published literature about the types of head and face shapes in the Alborz newborns. Therefore, we designed this study to report these important regional data. Methods: Head length, head width, face length, face width, prosopic and cephalic indices were made on 150 newborns (75 males and 75 females) with a view to establish the criterion of cephalometry for this age group in Iran. A special emphasis was given to delivery mode in this study. Results: There was no significant difference in cephalic and prosopic indices between two groups (female: p=0.46; male: p=0.43). Brachycephalic type was dominant and dolicocephalic type was rare in male and female neonates. There was no significant difference in head shape between two groups. Hypereuriprosopic and hyperleptoprosopic were dominant and rare types, respectively, in newborns without significant difference between two groups. Conclusion: The head and face indices in the newborn infants born by cesarean section were not significantly different from vaginal delivery group. However, the role of nutrition and climate could not be ruled out.

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Clinical Factors That Affect the Relationship between Head Circumference and Brain Volume in Very‐Low‐Birth‐Weight Infants

Abstract: Although HC has predictive value for TBV in VLBW infants, care should be taken in infants with low BBW (BBW less than 600 g) or dolichocephaly (MRI-based cranial index less than .68), which were related to overestimation of TBV.

Cited by 12 publications

References 24 publications

Early Ultrasonic Monitoring of Brain Growth and Later Neurodevelopmental Outcome in Very Preterm Infants

Early Ultrasonic Monitoring of Brain Growth and Later Neurodevelopmental Outcome in Very Preterm Infants

Genetic background of idiopathic neurodevelopmental delay patients with significant brain deviation volume

A descriptive study of Cephalic and prosopic anthropometric indices in one-day-old infants in Imam Ali and Kamali Hospital, Karaj

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