Clinical Factors Predictive of Pneumonia Caused by Pandemic 2009 H1N1 Influenza Virus

Kanchana, Sawan; Kanchana, Supannakhon; Vijitsopa, Teerapon; Thammakumpee, Kreeta; Yamwong, Sukit; Sawanyawisuth, Kittisak

doi:10.4269/ajtmh.12-0132

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…We also in depth analyzed the predictive factors of severe/critical novel coronavirus pneumonia. Patients with the symptoms of shortness of breath and nausea and vomiting tended to be severe, and the similar results related to H1N1 pneumonia had been revealed in previous report, showing that the symptoms mentioned above were risk factors (Kanchana et al, 2013, Na et al, 2011 . Lower lymphocytes level at initial of admission was also the significantly predictive factors, which were also described as prognostic indicators for ARDS and death in H5N1 and H1N1 infections (Chotpitayasunondh et al, 2005, Reyes et al, 2011 .…”

Section: Discussionsupporting

confidence: 86%

Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings

Zhang¹,

Cai²,

Hu³

et al. 2020

International Journal of Infectious Diseases

265

240

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J o u r n a l P r e -p r o o f 2 (Lanjuan Li); yidayang65@zju.edu.cn (Yida Yang) Highlight  COVID-19 has be a great threat to world health.  We aim to investigate clinical features of patients with abnormal imaging findings.  Those with abnormal images have more obvious clinical and laboratory features.  Combing clinical data with imaging score can predict severe/critical type. AbstractPurpose: To investigate the epidemiological, clinical characteristics of COVID-19 patients with abnormal imaging findings. Methods: Patients confirmed with SARS-CoV-2 infection of Zhejiang province fromJan 17 to Feb 8 underwent CT or x-ray were enrolled. Epidemiological, clinical data were analyzed between those with abnormal or normal imaging findings.Results: Excluding 72 patients with normal images, 230 of 573 patients affected more than two lobes. The median radiograph score was 2.0 and there's negative correlation between the score and oxygenation index (ρ=-0.657, P<0.001). Patients with abnormal images were older (46.65±13.82), with higher rate of coexisting condition(28.8%), lower rate of exposure history and longer time between onset and confirmation(5d) than non-pneumonia patients(all P<0.05). Higher rate of fever, cough, expectoration, and headache, lower lymphocytes, albumin, serum sodium levels and higher total bilirubin, creatine kinase, lactate dehydrogenase and C-reactive J o u r n a l P r e -p r o o f 3 protein levels and lower oxygenation index were observed in pneumonia patients (all P<0.05). Muscle ache, shortness of breath, nausea and vomiting, lower lymphocytes levels and higher serum creatinine and radiograph score at admission were predictive factors for severe/critical subtype. Conclusion:Patients with abnormal images have more obvious clinical manifestations and laboratory changes. Combing clinical features and radiograph score can effectively predict severe/critical type.

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Section: Discussionsupporting

confidence: 86%

Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings

Zhang¹,

Cai²,

Hu³

et al. 2020

International Journal of Infectious Diseases

265

240

View full text Add to dashboard Cite

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“…Neutrophilia is occasionally seen in human influenza infection [48] , though it is less common in the absence of pneumonia or bacterial co-infection [47] , [49] – [51] . All infected ferrets showed granulocytosis (CD11b+ cells; presumably mainly due to neutrophilia) for several days post-infection.…”

Section: Discussionmentioning

confidence: 99%

Influenza Vaccination Accelerates Recovery of Ferrets from Lymphopenia

et al. 2014

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Ferrets are a useful animal model for human influenza virus infections, since they closely mimic the pathogenesis of influenza viruses observed in humans. However, a lack of reagents, especially for flow cytometry of immune cell subsets, has limited research in this model. Here we use a panel of primarily species cross-reactive antibodies to identify ferret T cells, cytotoxic T lymphocytes (CTL), B cells, and granulocytes in peripheral blood. Following infection with seasonal H3N2 or H1N1pdm09 influenza viruses, these cell types showed rapid and dramatic changes in frequency, even though clinically the infections were mild. The loss of B cells and CD4 and CD8 T cells, and the increase in neutrophils, were especially marked 1–2 days after infection, when about 90% of CD8+ T cells disappeared from the peripheral blood. The different virus strains led to different kinetics of leukocyte subset alterations. Vaccination with homologous vaccine reduced clinical symptoms slightly, but led to a much more rapid return to normal leukocyte parameters. Assessment of clinical symptoms may underestimate the effectiveness of influenza vaccine in restoring homeostasis.

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“…Enhanced neutrophil recruitment is specifically thought to play an important role in the development of acute respiratory distress syndrome in severe influenza. In a study of 441 patients with A(H1N1)pdm09, patients with pneumonia had elevated absolute neutrophil counts compared to those without pneumonia [ 124 ]. As mentioned earlier, in murine models of fatal influenza infection, mortality correlated with neutrophil influx to the lungs.…”

Section: Neutrophils and Neutrophil Extracellular Trapsmentioning

confidence: 99%

Interactions of Influenza and SARS-CoV-2 with the Lung Endothelium: Similarities, Differences, and Implications for Therapy

Latreille

Lee

2021

Viruses

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Respiratory viruses such as influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are a constant threat to public health given their ability to cause global pandemics. Infection with either virus may lead to aberrant host responses, such as excessive immune cell recruitment and activation, dysregulated inflammation, and coagulopathy. These may contribute to the development of lung edema and respiratory failure. An increasing amount of evidence suggests that lung endothelial cells play a critical role in the pathogenesis of both viruses. In this review, we discuss how infection with influenza or SARS-CoV-2 may induce endothelial dysfunction. We compare the effects of infection of these two viruses, how they may contribute to pathogenesis, and discuss the implications for potential treatment. Understanding the differences between the effects of these two viruses on lung endothelial cells will provide important insight to guide the development of therapeutics.

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Clinical Factors Predictive of Pneumonia Caused by Pandemic 2009 H1N1 Influenza Virus

Cited by 7 publications

References 10 publications

Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings

Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings

Influenza Vaccination Accelerates Recovery of Ferrets from Lymphopenia

Interactions of Influenza and SARS-CoV-2 with the Lung Endothelium: Similarities, Differences, and Implications for Therapy

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