Clinical Factors Affecting prostate-specific Antigen Levels in Prostate Cancer Patients Undergoing Radical Prostatectomy: a Retrospective Study

Tarantino, Giovanni; Crocetto, Felice; Vito, Concetta Di; Martino, Raffaele; Pandolfo, Savio Domenico; Creta, Massimiliano; Aveta, Achille; Buonerba, Carlo; Imbimbo, Ciro

doi:10.2144/fsoa-2020-0154

Cited by 22 publications

(22 citation statements)

References 43 publications

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“…All study patients’ medical records were analyzed. The demographics and preoperative laboratory data that were collected for each patient included body mass index, age, American Society of Anesthesiologist (ASA) physical status, history of abdominal surgery, comorbidities (diabetes mellitus, hypertension, coronary artery disease, chronic kidney disease, cerebrovascular accident, or chronic obstructive pulmonary disease), medications (aspirin, clopidogrel, calcium channel blockers, angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker, and beta blocker), Gleason score, tumor stage, and preoperative laboratory values (prostate-specific antigen, hemoglobin, platelet, white blood cell, neutrophil, lymphocyte, platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, estimated glomerular filtration rate [eGFR], uric acid, albumin, AST, ALT, C-reactive protein, and the De Ritis ratio) [ 15 ]. The Chronic Kidney Disease Epidemiology Collaboration equation was used to calculate eGFR [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy

Park

Hong

et al. 2021

JPM

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Acute kidney injury (AKI) is related to mortality and morbidity. The De Ritis ratio, calculated by dividing the aspartate aminotransferase by the alanine aminotransferase, is used as a prognostic indicator. We evaluated risk factors for AKI after radical retropubic prostatectomy (RRP). This retrospective study included patients who performed RRP. Multivariable logistic regression analysis and a receiver operating characteristic (ROC) curve analysis were conducted. Other postoperative outcomes were also evaluated. Among the 1415 patients, 77 (5.4%) had AKI postoperatively. The multivariable logistic regression analysis showed that estimated glomerular filtration rate, albumin level, and the De Ritis ratio at postoperative day 1 were risk factors for AKI. The area under the ROC curve of the De Ritis ratio at postoperative day 1 was 0.801 (cutoff = 1.2). Multivariable-adjusted analysis revealed that the De Ritis ratio at ≥1.2 was significantly related to AKI (odds ratio = 8.637, p < 0.001). Postoperative AKI was associated with longer hospitalization duration (11 ± 5 days vs. 10 ± 4 days, p = 0.002). These results collectively show that an elevated De Ritis ratio at postoperative day 1 is associated with AKI after RRP in patients with prostate cancer.

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Section: Methodsmentioning

confidence: 99%

Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy

Park

Hong

et al. 2021

JPM

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“…PCa is one of the most diagnosed cancers globally, with an estimated incidence of 1,276,000 new cancer cases and 359,000 deaths in 2018. Several risk factors have been established (e.g., old age, family history, and African American ethnicity) [31][32][33]. PCa is the neoplasia that has the greatest impact on the male population and is the most frequently These two oncoproteins are able to bind p53, Bcl-2/surviving and retinoblastoma proteins, respectively, which are related to the cellular cycle control.…”

Section: Prostate Cancer (Pca)mentioning

confidence: 99%

Impact of Sexual Activity on the Risk of Male Genital Tumors: A Systematic Review of the Literature

Crocetto

Arcaniolo

Napolitano

et al. 2021

IJERPH

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Most cancers are related to lifestyle and environmental risk factors, including smoking, alcohol consumption, dietary habits, and environment (occupational exposures). A growing interest in the association between sexual activity (SA) and the development of different types of tumors in both men and women has been recorded in recent years. The aim of the present systematic review is to describe and critically discuss the current evidence regarding the association between SA and male genital cancers (prostatic, penile, and testicular), and to analyze the different theories and biological mechanisms reported in the literature. A comprehensive bibliographic search in the MEDLINE, Scopus, and Web of Science databases was performed in July 2021. Papers in the English language without chronological restrictions were selected. Retrospective and prospective primary clinical studies, in addition to previous systematic reviews and meta-analyses, were included. A total of 19 studies, including 953,704 patients were selected. Case reports, conference abstracts, and editorial comments were excluded. Men with more than 20 sexual partners in their lifetime, and those reporting more than 21 ejaculations per month, reported a decreased risk of overall and less aggressive prostate cancer (PCa). About 40% of penile cancers (PCs) were HPV-associated, with HPV 16 being the dominant genotype. Data regarding the risk of HPV in circumcised patients are conflicting, although circumcision appears to have a protective role against PC. Viral infections and epididymo-orchitis are among the main sex-related risk factors studied for testicular cancer (TC); however, data in the literature are limited. Testicular trauma can allow the identification of pre-existing TC. SA is closely associated with the development of PC through high-risk HPV transmission; in this context, phimosis appears to be a favoring factor. Sexual behaviors appear to play a significant role in PCa pathogenesis, probably through inflammatory mechanisms; however, protective sexual habits have also been described. A direct correlation between SA and TC has not yet been proven, although infections remain the most studied sex-related factor.

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“…This study also examined various factors that could modulate PSA levels and affect their correlation with cognitive function. Among the factors that could affect PSA or cognitive function, we analyzed arterial hypertension and history of stroke, myocardial infarction, or diabetes [35,36]. Most of these factors were not correlated with cognitive function except diabetes mellitus.…”

Section: Prostate-specific Antigenmentioning

confidence: 99%

Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes

Popiołek

Brzoszczyk

Jarzemski

et al. 2021

JCM

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Prostate cancer (PC) is one of the most common malignancies in men. The increase in the number of PC survivors is associated with many problems including cognitive impairment. Early detection of such problems facilitates timely protective intervention. This study examined the association between prostate-specific antigen (PSA) or testosterone (T) levels and cognitive function in patients undergoing radical prostatectomy. Such a correlation could help identify patient groups at risk of cognitive impairment. Participants underwent clinical (demographic data, medical history, physical examination, and blood analyses) and neuropsychological assessment (cognitive test battery). Preoperative PSA or T levels were not associated with cognitive function. However, long-term follow-up after prostatectomy showed a strong correlation between PSA levels and the results of verbal memory and executive function tests. A trend toward significance was also observed for visuospatial memory. The levels of free T and total T were not correlated with cognitive function. Only the levels of free T after hormonal treatment were significantly correlated with executive functions. Comorbid diabetes affected these correlations. In conclusion, PSA levels at a distant postoperative time and free T level after hormonal treatment may be biomarkers of cognitive function.

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Clinical Factors Affecting prostate-specific Antigen Levels in Prostate Cancer Patients Undergoing Radical Prostatectomy: a Retrospective Study

Cited by 22 publications

References 43 publications

Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy

Elevated De Ritis Ratio as a Predictor for Acute Kidney Injury after Radical Retropubic Prostatectomy

Impact of Sexual Activity on the Risk of Male Genital Tumors: A Systematic Review of the Literature

Prostate-Specific Antigen and Testosterone Levels as Biochemical Indicators of Cognitive Function in Prostate Cancer Survivors and the Role of Diabetes

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