Clinical Factor 2012

Balon, Richard

doi:10.1159/000351327

Cited by 7 publications

(8 citation statements)

References 53 publications

(32 reference statements)

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“…Neurosciences have exported their conceptual framework into psychiatry much more than serving as an investigative tool for addressing the questions entailed by clinical practice. Not surprisingly, there is a very limited amount of clinically relevant findings [52,53,54]. …”

Section: The Intellectual Crisis Of Psychiatric Researchmentioning

confidence: 99%

The Missing Link between Clinical States and Biomarkers in Mental Disorders

Fava

Guidi

Grandi

et al. 2014

Psychother Psychosom

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Current diagnostic definitions of psychiatric disorders based on collections of symptoms encompass very heterogeneous populations and are thus likely to yield spurious results when exploring biological correlates of mental disturbances. It has been suggested that large studies of biomarkers across diagnostic entities may yield improved clinical information. Such a view is based on the concept of assessment as a collection of symptoms devoid of any clinical judgment and interpretation. Yet, important advances have been made in recent years in clinimetrics, the science of clinical judgment. The current clinical taxonomy in psychiatry, which emphasizes reliability at the cost of clinical validity, does not include effects of comorbid conditions, timing of phenomena, rate of progression of an illness, responses to previous treatments, and other clinical distinctions that demarcate major prognostic and therapeutic differences among patients who otherwise seem to be deceptively similar since they share the same psychiatric diagnosis. Clinimetrics may provide the missing link between clinical states and biomarkers in psychiatry, building pathophysiological bridges from clinical manifestations to their neurobiological counterparts.

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Section: The Intellectual Crisis Of Psychiatric Researchmentioning

confidence: 99%

The Missing Link between Clinical States and Biomarkers in Mental Disorders

Fava

Guidi

Grandi

et al. 2014

Psychother Psychosom

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“…Richard Balon [13,14,15], in a series of annual papers, has tried to select investigations published in psychiatric journals which he perceived as having a high clinical factor. One is impressed by the amount of important research that has not been funded.…”

Section: The Intellectual Capital Of Medicinementioning

confidence: 99%

“…Meta-analyses should be carried out with sufficiently homogeneous patient groups [16]. We pursue the clinical factor [12,13,14,15] in the limited number of articles that we can publish.…”

Section: Our Journal's Missionmentioning

confidence: 99%

The Independence of Medical Journals and the Deceptive Effects of Open Access

Fava

2013

Psychother Psychosom

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“…As in the previous 4 years [1,2,3,4], I am presenting my subjective selection, this time of 16 (primary) articles published in the previous year (2014) that I believe may provide some information to help the reader improve his/her clinical practice. As I noted before, the idea was originally proposed by Giovanni Fava [5] with the goal of selecting papers that I would subjectively perceive as having a high ‘clinical factor' - the degree and extent to which a journal article provides information to the clinician that may improve his/her practice .…”

mentioning

confidence: 99%