“…A basic requirement for such studies is that shock be kept within the range of reversibility, since irreversible shock as defined in the laboratory is that late stage of shock which no longer responds to volume replacement with whole blood alone. Studies on irreversible experimental shock are of obvious interest for the treatment of re fractory clinical shock as seen in recovery rooms and shock units, but as shown by the experience of the U S Army shock groups working in Italy and in Korea [11,15], they have no bearing on the emergency treatment of hemorrhagic-traumatic shock in man [33,124,125,126].…”